NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components - sprookjes - yvandenbroek - TriplyDB

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

http://www.wikidata.org/entity/Q30576000

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Targeting MAPK Signaling in Age-Related Macular Degeneration Inflammation and its role in age-related macular degeneration Small Heterodimer Partner and Innate Immune Regulation NLRP3 Inflammasome and Pathobiology in AMD Photoreceptor cell death and rescue in retinal detachment and degenerations Molecular pathology of macrophages and interleukin-17 in age-related macular degeneration NLRP3 inflammasome: activation and regulation in age-related macular degeneration Mechanisms of age-related macular degeneration Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration Myeloid cells expressing VEGF and arginase-1 following uptake of damaged retinal pigment epithelium suggests potential mechanism that drives the onset of choroidal angiogenesis in mice Geographic Atrophy and Choroidal Neovascularization in the Same Eye: A Review Catalytic Properties and Biomedical Applications of Cerium Oxide Nanoparticles PKR promotes choroidal neovascularization via upregulating the PI3K/Akt signaling pathway in VEGF expression Viral infection of the lung: host response and sequelae Subconjunctival Palomid 529 in the treatment of neovascular age-related macular degeneration The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages Complement system in pathogenesis of AMD: dual player in degeneration and protection of retinal tissue.The interleukin-1 family: back to the future Xenobiotic pregnane X receptor (PXR) regulates innate immunity via activation of NLRP3 inflammasome in vascular endothelial cells DICER1/Alu RNA dysmetabolism induces Caspase-8-mediated cell death in age-related macular degeneration.Inflammation and Cell Death in Age-Related Macular Degeneration: An Immunopathological and Ultrastructural Model.Clinical characteristics and current treatment of age-related macular degeneration.Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives.CD200R signaling inhibits pro-angiogenic gene expression by macrophages and suppresses choroidal neovascularization.T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration Interleukin-17 retinotoxicity is prevented by gene transfer of a soluble interleukin-17 receptor acting as a cytokine blocker: implications for age-related macular degeneration.Inflammasomes Induced by 7-Ketocholesterol and Other Stimuli in RPE and in Bone Marrow-Derived Cells Differ Markedly in Their Production of IL-1β and IL-18.Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: reciprocal suppression with VEGF.Upregulation of NLRP3 Inflammasome in the Tears and Ocular Surface of Dry Eye Patients.Interleukin-1β Level Is Increased in Vitreous of Patients with Neovascular Age-Related Macular Degeneration (nAMD) and Polypoidal Choroidal Vasculopathy (PCV).Modifying Choroidal Neovascularization Development with a Nutritional Supplement in Mice A chimeric Cfh transgene leads to increased retinal oxidative stress, inflammation, and accumulation of activated subretinal microglia in mice Inflammatory Mechanisms of Age-related Macular Degeneration.Expression of Cytokines, Chmokines and Growth Factors in Patients Undergoing Cataract Surgery with Femtosecond Laser Pretreatment.Iron Toxicity in the Retina Requires Alu RNA and the NLRP3 Inflammasome Nucleoside Reverse Transcriptase Inhibitors Suppress Laser-Induced Choroidal Neovascularization in Mice.Receptor-Mediated Mechanism Controlling Tissue Levels of Bioactive Lipid Oxidation Products Angiopoietin-like Protein 2 Is a Multistep Regulator of Inflammatory Neovascularization in a Murine Model of Age-related Macular Degeneration.Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.Intravitreal dobesilate in the treatment of choroidal neovascularisation associated with age-related macular degeneration: report of two cases.

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P2860

NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components

http://www.wikidata.org/entity/Q30576000

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P2860

Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Ranibizumab and bevacizumab for neovascular age-related macular degeneration

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Global data on visual impairment in the year 2002

A role for mitochondria in NLRP3 inflammasome activation

Gout-associated uric acid crystals activate the NALP3 inflammasome

Cryopyrin activates the inflammasome in response to toxins and ATP

Origin and physiological roles of inflammation

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

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10.1038/NM.2717

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5

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223966220

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