Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration - sprookjes - yvandenbroek - TriplyDB

Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration

Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration

http://www.wikidata.org/entity/Q30856906

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Extracellular Vesicles as New Players in Cellular Senescence Inflammation and its role in age-related macular degeneration Parainflammation, chronic inflammation, and age-related macular degeneration NLRP3 Inflammasome and Pathobiology in AMD Photoreceptor cell death and rescue in retinal detachment and degenerations Autophagy and heterophagy dysregulation leads to retinal pigment epithelium dysfunction and development of age-related macular degeneration Roles for the ubiquitin-proteasome pathway in protein quality control and signaling in the retina: implications in the pathogenesis of age-related macular degeneration It's a cell-eat-cell world: autophagy and phagocytosis.The Evolving Functions of Autophagy in Ocular Health: A Double-edged Sword The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number.Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration Changes in retinal pigment epithelium related to cigarette smoke: possible relevance to smoking as a risk factor for age-related macular degeneration.Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients Animals as models of age-related macular degeneration: an imperfect measure of the truth.Abundant lipid and protein components of drusen Involvement of Nrf2 in Ocular Diseases.Early AMD-like defects in the RPE and retinal degeneration in aged mice with RPE-specific deletion of Atg5 or Atg7 Inhibition or Stimulation of Autophagy Affects Early Formation of Lipofuscin-Like Autofluorescence in the Retinal Pigment Epithelium Cell.Circadian and noncircadian modulation of autophagy in photoreceptors and retinal pigment epithelium.αB crystallin is apically secreted within exosomes by polarized human retinal pigment epithelium and provides neuroprotection to adjacent cells Interactome Mapping Guided by Tissue-Specific Phosphorylation in Age-Related Macular Degeneration.Cholesterol in the retina: the best is yet to come.Quantitative proteomics: comparison of the macular Bruch membrane/choroid complex from age-related macular degeneration and normal eyes Age-related retinopathy in NRF2-deficient mice.Autophagy impairment induces premature senescence in primary human fibroblasts.Acidic nanoparticles are trafficked to lysosomes and restore an acidic lysosomal pH and degradative function to compromised ARPE-19 cells.AlphaB-crystallin is found in detergent-resistant membrane microdomains and is secreted via exosomes from human retinal pigment epithelial cells Conditional ablation of the choroideremia gene causes age-related changes in mouse retinal pigment epithelium.Inflammatory cytokines protect retinal pigment epithelial cells from oxidative stress-induced death.Targeting Neovascularization in Ischemic Retinopathy: Recent Advances Aging, age-related macular degeneration, and the response-to-retention of apolipoprotein B-containing lipoproteins.Human aqueous humor exosomes.Biomolecular characterization of exosomes released from cancer stem cells: Possible implications for biomarker and treatment of cancer.Lipofuscin redistribution and loss accompanied by cytoskeletal stress in retinal pigment epithelium of eyes with age-related macular degeneration.Biodistribution and delivery efficiency of unmodified tumor-derived exosomes Lack of Acid Sphingomyelinase Induces Age-Related Retinal Degeneration Inflammatory Mechanisms of Age-related Macular Degeneration.Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium.Autophagy modulates articular cartilage vesicle formation in primary articular chondrocytes Impairing autophagy in retinal pigment epithelium leads to inflammasome activation and enhanced macrophage-mediated angiogenesis.

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Autophagy and exosomes in the aged retinal pigment epithelium: possible relevance to drusen formation and age-related macular degeneration

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Autophagy and exosomes in the ...... e-related macular degeneration

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Ai Ling Wang

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Arthur H Neufeld

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Mark O Tso

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Ming Yuan

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A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy

A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration

Selective degradation of mitochondria by mitophagy

CFH haplotypes without the Y402H coding variant show strong association with susceptibility to age-related macular degeneration

Loss of autophagy in the central nervous system causes neurodegeneration in mice

The role of autophagy in age-related neurodegeneration

HTRA1 promoter polymorphism in wet age-related macular degeneration

ARPE-19, a human retinal pigment epithelial cell line with differentiated properties

Mitochondrial fragmentation in neurodegeneration

Tetraspanin CD81 is required for the alpha v beta5-integrin-dependent particle-binding step of RPE phagocytosis

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