A tumor-specific kinase activity regulates the viral death protein Apoptin. - sprookjes - yvandenbroek - TriplyDB

A tumor-specific kinase activity regulates the viral death protein Apoptin.

A tumor-specific kinase activity regulates the viral death protein Apoptin.

http://www.wikidata.org/entity/Q31115267

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Interaction with PI3-kinase contributes to the cytotoxic activity of apoptin Targeting caspases in cancer therapeutics Modeling of molecular interaction between apoptin, BCR-Abl and CrkL--an alternative approach to conventional rational drug design Creation of an apoptin-derived peptide that interacts with SH3 domains and inhibits glioma cell migration and invasion.Mitotic catastrophe triggered in human cancer cells by the viral protein apoptin.Apoptin-induced cell death is modulated by Bcl-2 family members and is Apaf-1 dependent.The anticancer gene ORCTL3 targets stearoyl-CoA desaturase-1 for tumour-specific apoptosis pH-sensitive degradable nanoparticles for highly efficient intracellular delivery of exogenous protein λ Phage nanobioparticle expressing apoptin efficiently suppress human breast carcinoma tumor growth in vivo.Enhanced tumour cell nuclear targeting in a tumour progression model.Apoptin: specific killer of tumor cells?Specific isoforms of p73 control the induction of cell death induced by the viral proteins, E1A or apoptin Unscheduled Akt-triggered activation of cyclin-dependent kinase 2 as a key effector mechanism of apoptin's anticancer toxicity.Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral Replication C-terminal region of apoptin affects chicken anemia virus replication and virulence.Targeting the anaphase promoting complex: common pathways for viral infection and cancer therapy.Naturally occurring, tumor-specific, therapeutic proteins.Mechanisms of Apoptin-induced cell death.Viral genes as oncolytic agents for cancer therapy.Transcriptomic Profiling of Virus-Host Cell Interactions following Chicken Anaemia Virus (CAV) Infection in an In Vivo Model.Cancer suicide gene therapy: a patent review.DNA damage response signaling triggers nuclear localization of the chicken anemia virus protein Apoptin.Apoptin interacts with and regulates the activity of protein kinase C beta in cancer cells.Selective apoptosis induction in MCF-7 cell line by truncated minimal functional region of Apoptin.Human Gyrovirus Apoptin shows a similar subcellular distribution pattern and apoptosis induction as the chicken anaemia virus derived VP3/Apoptin.PP2A inactivation is a crucial step in triggering apoptin-induced tumor-selective cell killing Delivery of therapeutic proteins as secretable TAT fusion products.Apoptin protein multimers form distinct higher-order nucleoprotein complexes with DNA.Activation of the tumor-specific death effector apoptin and its kinase by an N-terminal determinant of simian virus 40 large T antigen.Akt is transferred to the nucleus of cells treated with apoptin, and it participates in apoptin-induced cell death.Apoptin is modified by SUMO conjugation and targeted to promyelocytic leukemia protein nuclear bodies.Apoptin nucleocytoplasmic shuttling is required for cell type-specific localization, apoptosis, and recruitment of the anaphase-promoting complex/cyclosome to PML bodies.A truncated apoptin protein variant selectively kills cancer cells.Importance of nuclear localization of apoptin for tumor-specific induction of apoptosis.Relevance of apoptin's integrity for its functional behavior.Apoptin/VP3 contains a concentration-dependent nuclear localization signal (NLS), not a tumorigenic selective NLS.Canine Parvovirus ns1 gene and Chicken Anemia vp3 gene induce partial oncolysis of Canine Transmissible Venereal Tumor.Marek’s disease virus oncoprotein Meq physically interacts with the chicken infectious anemia virus-encoded apoptotic protein apoptin.

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P2860

A tumor-specific kinase activity regulates the viral death protein Apoptin.

http://www.wikidata.org/entity/Q31115267

description

2002 nî lūn-bûn

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2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2002 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2002年の論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年論文

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2002年论文

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name

A tumor-specific kinase activity regulates the viral death protein Apoptin.

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A tumor-specific kinase activity regulates the viral death protein Apoptin.

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type

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A tumor-specific kinase activity regulates the viral death protein Apoptin.

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A tumor-specific kinase activity regulates the viral death protein Apoptin.

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prefLabel

A tumor-specific kinase activity regulates the viral death protein Apoptin.

@ast

A tumor-specific kinase activity regulates the viral death protein Apoptin.

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Journal of Biological Chemistry

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A tumor-specific kinase activity regulates the viral death protein Apoptin.

@en

P2093

Cornelis J H Van De Velde

http://www.w3.org/2001/XMLSchema#string

Dominik Mumberg

http://www.w3.org/2001/XMLSchema#string

Jeroen Den Hertog

http://www.w3.org/2001/XMLSchema#string

Mathieu H M Noteborn

http://www.w3.org/2001/XMLSchema#string

Niek V Henriquez

http://www.w3.org/2001/XMLSchema#string

Norbert Otto

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Peter Donner

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Peter J K Kuppen

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Remco I J M Aalbers

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Ying-Hui Zhang

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P2860

The Hallmarks of Cancer

Putting tumours in context

The regulation of protein function by multisite phosphorylation--a 25 year update.

Enumeration of the simian virus 40 early region elements necessary for human cell transformation

Rational therapeutic intervention in cancer: kinases as drug targets.

Perspectives on the development of a molecularly targeted agent.

Apoptin induces apoptosis in human transformed and malignant cells but not in normal cells.

The chicken anemia virus-derived protein apoptin requires activation of caspases for induction of apoptosis in human tumor cells.

Human papillomavirus E6 and E7: proteins which deregulate the cell cycle.

Transformation and immortalization of diploid xeroderma pigmentosum fibroblasts.

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50820-50827

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scholarly article

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10.1074/JBC.M208557200

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P433

52

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P478

277

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Mathieu H. M. Noteborn

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2002-10-21T00:00:00Z

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P698

12393903

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