An activation switch in the ligand binding pocket of the C5a receptor.
about
The role of the N-terminal domain of the complement fragment receptor C5L2 in ligand bindingFunction, structure and therapeutic potential of complement C5a receptorsAdvances in Determination of a High-Resolution Three-Dimensional Structure of Rhodopsin, a Model of G-Protein-Coupled Receptors (GPCRs)Structural and functional characterization of human and murine C5a anaphylatoxinsDisulfide trapping to localize small-molecule agonists and antagonists for a G protein-coupled receptor.Random mutagenesis of the complement factor 5a (C5a) receptor N terminus provides a structural constraint for C5a docking.Structure of the complement factor 5a receptor-ligand complex studied by disulfide trapping and molecular modeling.ss-TEA: Entropy based identification of receptor specific ligand binding residues from a multiple sequence alignment of class A GPCRs.Molecular basis of ligand dissociation in β-adrenergic receptorsThird extracellular loop (EC3)-N terminus interaction is important for seven-transmembrane domain receptor function: implications for an activation microswitch region.The crystallographic model of rhodopsin and its use in studies of other G protein-coupled receptors.Retrieving novel C5aR antagonists using a hybrid ligand-based virtual screening protocol based on SVM classification and pharmacophore models.Complement System Part I - Molecular Mechanisms of Activation and Regulation.Targeting the minor pocket of C5aR for the rational design of an oral allosteric inhibitor for inflammatory and neuropathic pain reliefThe role of the anaphylatoxins in health and disease.Agonist binding by the β2-adrenergic receptor: an effect of receptor conformation on ligand association-dissociation characteristicsInsights into the mechanism of C5aR inhibition by PMX53 via implicit solvent molecular dynamics simulations and dockingOrganization and functions of interacting domains for signaling by protein-protein interactions.Hallucinogen actions on 5-HT receptors reveal distinct mechanisms of activation and signaling by G protein-coupled receptors.Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site.A peptide mimic of the chemotaxis inhibitory protein of Staphylococcus aureus: towards the development of novel anti-inflammatory compounds.Conserved helix 7 tyrosine acts as a multistate conformational switch in the 5HT2C receptor. Identification of a novel "locked-on" phenotype and double revertant mutations.Simplified modeling approach suggests structural mechanisms for constitutive activation of the C5a receptor.Transmembrane domains 4 and 7 of the M(1) muscarinic acetylcholine receptor are critical for ligand binding and the receptor activation switch.The core domain of chemokines binds CCR5 extracellular domains while their amino terminus interacts with the transmembrane helix bundle.The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins.Site-specific disulfide capture of agonist and antagonist peptides on the C5a receptor.Molecular mechanism underlying partial and full agonism mediated by the human cholecystokinin-1 receptor.Identification of an agonist-induced conformational change occurring adjacent to the ligand-binding pocket of the M(3) muscarinic acetylcholine receptor.
P2860
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P2860
An activation switch in the ligand binding pocket of the C5a receptor.
description
2000 nî lūn-bûn
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2000 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի նոյեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
An activation switch in the ligand binding pocket of the C5a receptor.
@ast
An activation switch in the ligand binding pocket of the C5a receptor.
@en
type
label
An activation switch in the ligand binding pocket of the C5a receptor.
@ast
An activation switch in the ligand binding pocket of the C5a receptor.
@en
prefLabel
An activation switch in the ligand binding pocket of the C5a receptor.
@ast
An activation switch in the ligand binding pocket of the C5a receptor.
@en
P2093
P2860
P356
P1476
An activation switch in the ligand binding pocket of the C5a receptor.
@en
P2093
P2860
P304
P356
10.1074/JBC.M007748200
P407
P577
2000-11-02T00:00:00Z