E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.
about
p38 phosphorylates Rb on Ser567 by a novel, cell cycle-independent mechanism that triggers Rb-Hdm2 interaction and apoptosisTranscriptional control of stem cell fate by E2Fs and pocket proteinsThe proapoptotic gene SIVA is a direct transcriptional target for the tumor suppressors p53 and E2F1Inhibition of cyclin-dependent kinases improves CA1 neuronal survival and behavioral performance after global ischemia in the ratHypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress.Regulation of ischemic neuronal death by E2F4-p130 protein complexesResponse of cell cycle proteins to neurotrophic factor and chemokine stimulation in human neuroglia.The neuroprotective effects of phytoestrogens on amyloid beta protein-induced toxicity are mediated by abrogating the activation of caspase cascade in rat cortical neurons.The modular systems biology approach to investigate the control of apoptosis in Alzheimer's disease neurodegeneration.Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits.Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim.Repair of oxidative DNA damage, cell-cycle regulation and neuronal death may influence the clinical manifestation of Alzheimer's disease.E2F1 localizes predominantly to neuronal cytoplasm and fails to induce expression of its transcriptional targets in human immunodeficiency virus-induced neuronal damage.Multiple cyclin-dependent kinases signals are critical mediators of ischemia/hypoxic neuronal death in vitro and in vivo.Neuronal life and death: an essential role for the p53 family.α7 Nicotinic receptor activation reduces β-amyloid-induced apoptosis by inhibiting caspase-independent death through phosphatidylinositol 3-kinase signaling.Alzheimer's disease and Abeta toxicity: from top to bottom.Mitochondrial and Cell Death Mechanisms in Neurodegenerative Diseases.ROS production is essential for the apoptotic function of E2F1 in pheochromocytoma and neuroblastoma cell lines.Inflammation, apoptosis, and Alzheimer's disease.The p53 homologue p73 accumulates in the nucleus and localizes to neurites and neurofibrillary tangles in Alzheimer disease brain.Cycling at the interface between neurodevelopment and neurodegeneration.Functional role of RNA polymerase II and P70 S6 kinase in KCl withdrawal-induced cerebellar granule neuron apoptosis.E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity.Neuronal cell cycle: the neuron itself and its circumstancesCell cycle molecules and vertebrate neuron death: E2F at the hub.Neuropilin-1 is a direct target of the transcription factor E2F1 during cerebral ischemia-induced neuronal death in vivo.Alterations in G(1) to S phase cell-cycle regulators during amyotrophic lateral sclerosis.Inhibition of Bax protects neuronal cells from oligomeric Aβ neurotoxicityMitochondrial dysfunction and Alzheimer's disease: role of amyloid-beta peptide alcohol dehydrogenase (ABAD).Caspase-dependent degradation of MDMx/MDM4 cell cycle regulatory protein in amyloid β-induced neuronal damage.Loss of E2F1 Extends Survival and Accelerates Oral Tumor Growth in HPV-Positive MiceRegulation of Neuronal Cell Cycle and Apoptosis by MicroRNA 34aPrimate-specific miR-603 is implicated in the risk and pathogenesis of Alzheimer's disease.Differential roles for caspase-mediated and calpain-mediated cell death in 1- and 3-week-old rat cortical culturesCell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitisAltered distribution of cell cycle transcriptional regulators during Alzheimer disease.Is the time dimension of the cell cycle re-entry in AD regulated by centromere cohesion dynamics?Cyclin-dependent kinase 5 is a mediator of dopaminergic neuron loss in a mouse model of Parkinson's disease.The chemokine receptor CXCR4 regulates cell-cycle proteins in neurons.
P2860
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P2860
E2F1 mediates death of B-amyloid-treated cortical neurons in a manner independent of p53 and dependent on Bax and caspase 3.
description
2000 nî lūn-bûn
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2000 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
E2F1 mediates death of B-amylo ...... ependent on Bax and caspase 3.
@ast
E2F1 mediates death of B-amylo ...... ependent on Bax and caspase 3.
@en
type
label
E2F1 mediates death of B-amylo ...... ependent on Bax and caspase 3.
@ast
E2F1 mediates death of B-amylo ...... ependent on Bax and caspase 3.
@en
prefLabel
E2F1 mediates death of B-amylo ...... ependent on Bax and caspase 3.
@ast
E2F1 mediates death of B-amylo ...... ependent on Bax and caspase 3.
@en
P2093
P356
P1476
E2F1 mediates death of B-amylo ...... dependent on Bax and caspase 3
@en
P2093
A Giovanni
E J Morris
E Keramaris
G S Robertson
P304
11553-11560
P356
10.1074/JBC.275.16.11553
P407
P577
2000-04-01T00:00:00Z