Antisense oligonucleotides against thrombospondin-1 inhibit activation of tgf-beta in fibrotic renal disease in the rat in vivo.
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Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cellsEverolimus inhibits glomerular endothelial cell proliferation and VEGF, but not long-term recovery in experimental thrombotic microangiopathy.Correlation of enhanced thrombospondin-1 expression, TGF-beta signalling and proteinuria in human type-2 diabetic nephropathy.Thrombospondin-2 therapy ameliorates experimental glomerulonephritis via inhibition of cell proliferation, inflammation, and TGF-beta activation.Glucose downregulation of PKG-I protein mediates increased thrombospondin1-dependent TGF-{beta} activity in vascular smooth muscle cellsLong-term gene therapy with thrombospondin 2 inhibits TGF-β activation, inflammation and angiogenesis in chronic allograft nephropathyTSP-1 promotes glomerular mesangial cell proliferation and extracellular matrix secretion in Thy-1 nephritis ratsTissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration.Influence of ginsenoside Rg1, a panaxatriol saponin from Panax notoginseng, on renal fibrosis in rats with unilateral ureteral obstruction.Silencing CD36 gene expression results in the inhibition of latent-TGF-beta1 activation and suppression of silica-induced lung fibrosis in the rat.Constitutive thrombospondin-1 overexpression contributes to autocrine transforming growth factor-beta signaling in cultured scleroderma fibroblasts.Role of thrombospondin 1 in liver diseases.Exploring RNA interference as a therapeutic strategy for renal disease.Lipoxin A4 modifies platelet-derived growth factor-induced pro-fibrotic gene expression in human renal mesangial cells.TSP-1 in lung fibrosisInterstitial pneumonia induced by bleomycin treatment is exacerbated in Angptl2-deficient mice.Ginsenoside Rg1 modulation on thrombospondin-1 and vascular endothelial growth factor expression in early renal fibrogenesis in unilateral obstruction.Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure.[Role of thrombospondin-1 in the development of kidney diseases].When the lung is stretched, could it be thrombospondin via TGFbeta1 peptide activation?Thrombospondin-1 and thrombospondin-2 mRNA and TSP-1 and TSP-2 protein expression in uterine fibroids and correlation to the genes COL1A1 and COL3A1 and to the collagen cross-link hydroxyproline.LSKL, a peptide antagonist of thrombospondin-1, attenuates renal interstitial fibrosis in rats with unilateral ureteral obstruction.
P2860
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P2860
Antisense oligonucleotides against thrombospondin-1 inhibit activation of tgf-beta in fibrotic renal disease in the rat in vivo.
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Antisense oligonucleotides aga ...... al disease in the rat in vivo.
@ast
Antisense oligonucleotides aga ...... al disease in the rat in vivo.
@en
type
label
Antisense oligonucleotides aga ...... al disease in the rat in vivo.
@ast
Antisense oligonucleotides aga ...... al disease in the rat in vivo.
@en
prefLabel
Antisense oligonucleotides aga ...... al disease in the rat in vivo.
@ast
Antisense oligonucleotides aga ...... al disease in the rat in vivo.
@en
P2093
P2860
P1476
Antisense oligonucleotides aga ...... nal disease in the rat in vivo
@en
P2093
Christian Hugo
Harald Rupprecht
Hiroshi Kawashi
Yoshitaka Isaka
Yoshitugu Takabatake
P2860
P304
P356
10.1016/S0002-9440(10)63478-5
P407
P577
2003-09-01T00:00:00Z