Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.
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A Single Active-Site Mutation of P450BM-3 Dramatically Enhances Substrate Binding and Rate of Product FormationStructural evidence: a single charged residue affects substrate binding in cytochrome P450 BM-3Variations on a (t)heme--novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamilyEngineering cytochrome P450 biocatalysts for biotechnology, medicine and bioremediationEngineering P450 Peroxygenase to Catalyze Highly Enantioselective Epoxidation of cis-β-Methylstyrenes.Directed evolution strategies for enantiocomplementary haloalkane dehalogenases: from chemical waste to enantiopure building blocks.An efficient route to selective bio-oxidation catalysts: an iterative approach comprising modeling, diversification, and screening, based on CYP102A1.Replacement of natural cofactors by selected hydrogen peroxide donors or organic peroxides results in improved activity for CYP3A4 and CYP2D6.A panel of cytochrome P450 BM3 variants to produce drug metabolites and diversify lead compounds.Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects.P450(BM3) (CYP102A1): connecting the dots.Achieving regio- and enantioselectivity of P450-catalyzed oxidative CH activation of small functionalized molecules by structure-guided directed evolution.Design of a cytochrome P450BM3 reaction system linked by two-step cofactor regeneration catalyzed by a soluble transhydrogenase and glycerol dehydrogenase.Engineered P450pyr monooxygenase for asymmetric epoxidation of alkenes with unique and high enantioselectivity.Development of a whole-cell biocatalyst co-expressing P450 monooxygenase and glucose dehydrogenase for synthesis of epoxyhexane.Immobilization of a Bacterial Cytochrome P450 Monooxygenase System on a Solid Support.P450 BM3-Catalyzed Regio- and Stereoselective Hydroxylation Aiming at the Synthesis of Phthalides and Isocoumarins.Asymmetric epoxidation of alkenes and benzylic hydroxylation with P450tol monooxygenase from Rhodococcus coprophilus TC-2.Creating protein biocatalysts as tools for future industrial applicationsDiscovery and Protein Engineering of Biocatalysts for Organic SynthesisPhosphite-driven Self-sufficient Cytochrome P450
P2860
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P2860
Enantioselective epoxidation of terminal alkenes to (R)- and (S)-epoxides by engineered cytochromes P450 BM-3.
description
2006 nî lūn-bûn
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2006 թուականի Յունուարին հրատարակուած գիտական յօդուած
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2006 թվականի հունվարին հրատարակված գիտական հոդված
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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name
Enantioselective epoxidation o ...... ineered cytochromes P450 BM-3.
@ast
Enantioselective epoxidation o ...... ineered cytochromes P450 BM-3.
@en
type
label
Enantioselective epoxidation o ...... ineered cytochromes P450 BM-3.
@ast
Enantioselective epoxidation o ...... ineered cytochromes P450 BM-3.
@en
prefLabel
Enantioselective epoxidation o ...... ineered cytochromes P450 BM-3.
@ast
Enantioselective epoxidation o ...... ineered cytochromes P450 BM-3.
@en
P2093
P356
P1476
Enantioselective epoxidation o ...... ineered cytochromes P450 BM-3.
@en
P2093
Matthew W Peters
Peter Meinhold
Takafumi Kubo
P304
P356
10.1002/CHEM.200500584
P407
P577
2006-01-01T00:00:00Z