Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections
about
Preliminary crystallographic studies of the regulatory domain of response regulator YycF from an essential two-component signal transduction systemA biochemical characterization of the DNA binding activity of the response regulator VicR from Streptococcus mutansIdentification of a Small Molecule Inhibitor of RAD52 by Structure-Based SelectionAn inhibitor of gram-negative bacterial virulence protein secretionDiscovery of novel inhibitors of Streptococcus pneumoniae based on the virtual screening with the homology-modeled structure of histidine kinase (VicK).Efficacy of novel antibacterial compounds targeting histidine kinase YycG protein.Challenges of antibacterial discoveryKinetic characterization of the WalRKSpn (VicRK) two-component system of Streptococcus pneumoniae: dependence of WalKSpn (VicK) phosphatase activity on its PAS domain.Thiazolidione derivatives targeting the histidine kinase YycG are effective against both planktonic and biofilm-associated Staphylococcus epidermidis.The effect of the potential PhoQ histidine kinase inhibitors on Shigella flexneri virulencePurification and activity testing of the full-length YycFGHI proteins of Staphylococcus aureus.Essential genes in Bacillus subtilis: a re-evaluation after ten years.Site-specific mutation of Staphylococcus aureus VraS reveals a crucial role for the VraR-VraS sensor in the emergence of glycopeptide resistance.Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence.Inactivation of multiple bacterial histidine kinases by targeting the ATP-binding domain.Antibacterial and anti-biofilm activities of thiazolidione derivatives against clinical staphylococcus strains.WalK, the Path towards New Antibacterials with Low Potential for Resistance DevelopmentAntibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK).The Essential WalK Histidine Kinase and WalR Regulator Differentially Mediate Autolysis of Staphylococcus aureus RN4220Putative histidine kinase inhibitors with antibacterial effect against multi-drug resistant clinical isolates identified by in vitro and in silico screens.Anti-bacterial and Anti-biofilm Evaluation of Thiazolopyrimidinone Derivatives Targeting the Histidine Kinase YycG Protein of Staphylococcus epidermidis.Combating biofilms.The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases.The Response Regulator YycF Inhibits Expression of the Fatty Acid Biosynthesis Repressor FabT in Streptococcus pneumoniae.Development of an antivirulence drug against Streptococcus mutans: repression of biofilm formation, acid tolerance, and competence by a histidine kinase inhibitor, walkmycin CEssentiality, bypass, and targeting of the YycFG (VicRK) two-component regulatory system in gram-positive bacteria.Two-Component Signal Transduction Systems of Pathogenic Bacteria As Targets for Antimicrobial Therapy: An Overview.Mechanistic insight into inhibition of two-component system signaling.Crystallographic characterization of a multidomain histidine protein kinase from an essential two-component regulatory system.Substituted 2-imino-5-arylidenethiazolidin-4-one inhibitors of bacterial type III secretion.Novel antibacterial compounds specifically targeting the essential WalR response regulator.Waldiomycin, a novel WalK-histidine kinase inhibitor from Streptomyces sp. MK844-mF10.Angucycline antibiotic waldiomycin recognizes common structural motif conserved in bacterial histidine kinases.Potent and selective inhibitors of Staphylococcus epidermidis tryptophanyl-tRNA synthetase.Application of intelligent techniques for classification of bacteria using protein sequence-derived features.Antibacterial effects of phage lysin LysGH15 on planktonic cells and biofilms of diverse staphylococci.An integrative, multi-omics approach towards the prioritization of Klebsiella pneumoniae drug targets.Adhesive properties of Staphylococcus epidermidis probed by atomic force microscopy
P2860
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P2860
Structure-based discovery of inhibitors of the YycG histidine kinase: new chemical leads to combat Staphylococcus epidermidis infections
description
2006 nî lūn-bûn
@nan
2006 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Structure-based discovery of i ...... ococcus epidermidis infections
@ast
Structure-based discovery of i ...... ococcus epidermidis infections
@en
Structure-based discovery of i ...... coccus epidermidis infections.
@nl
type
label
Structure-based discovery of i ...... ococcus epidermidis infections
@ast
Structure-based discovery of i ...... ococcus epidermidis infections
@en
Structure-based discovery of i ...... coccus epidermidis infections.
@nl
prefLabel
Structure-based discovery of i ...... ococcus epidermidis infections
@ast
Structure-based discovery of i ...... ococcus epidermidis infections
@en
Structure-based discovery of i ...... coccus epidermidis infections.
@nl
P2093
P2860
P356
P1433
P1476
Structure-based discovery of i ...... ococcus epidermidis infections
@en
P2093
Hualiang Jiang
Jian Zhang
Xiaomei Yang
Zhiqiang Qin
P2860
P2888
P356
10.1186/1471-2180-6-96
P577
2006-11-10T00:00:00Z
P5875
P6179
1029870621