T (brachyury) gene duplication confers major susceptibility to familial chordoma.
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Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinomaBrachyury, a driver of the epithelial-mesenchymal transition, is overexpressed in human lung tumors: an opportunity for novel interventions against lung cancerIntegrative cancer epidemiology--the next generationPaediatric ChordomasNovel uses of immunohistochemistry in the diagnosis and classification of soft tissue tumorsFunctional Brachyury binding sites establish a temporal read-out of gene expression in the Ciona notochordRare Germline Copy Number Variations and Disease Susceptibility in Familial MelanomaA novel chordoma xenograft allows in vivo drug testing and reveals the importance of NF-κB signaling in chordoma biologyCross-species array comparative genomic hybridization identifies novel oncogenic events in zebrafish and human embryonal rhabdomyosarcomaNuances in the treatment of malignant tumors of the clival and petroclival region.Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional-based study.Molecular characterization of putative chordoma cell linesClinical features distinguish childhood chordoma associated with tuberous sclerosis complex (TSC) from chordoma in the general paediatric population.The biological basis for modern treatment of chordoma.Recurrent chromosomal copy number alterations in sporadic chordomas.Generation of chordoma cell line JHC7 and the identification of Brachyury as a novel molecular target.Parapharyngeal chordoma: a diagnostic challenge and potential mimic of pleomorphic adenoma on fine-needle aspiration cytology.An integrated functional genomics approach identifies the regulatory network directed by brachyury (T) in chordoma.Novel therapeutic targets in chordoma.'The chicken or the egg?' dilemma strikes back for the controlling mechanism in chordoma(#).High-resolution whole-genome analysis of skull base chordomas implicates FHIT loss in chordoma pathogenesisA common single-nucleotide variant in T is strongly associated with chordoma.Highly proliferative sellar chordoma with unusually rapid recurrence.Incidence and relative survival of chordomas: the standardized mortality ratio and the impact of chordomas on a population.From notochord formation to hereditary chordoma: the many roles of Brachyury.Converging paths to progress for skull base chordoma: Review of current therapy and future molecular targets.Molecular and clinical risk factors for recurrence of skull base chordomas: gain on chromosome 2p, expression of brachyury, and lack of irradiation negatively correlate with patient prognosis.Tissue microarray immunohistochemical detection of brachyury is not a prognostic indicator in chordomaThe brachyury Gly177Asp SNP is not associated with a risk of skull base chordoma in the Chinese population.A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12Molecular pathology of bone tumours: diagnostic implications.The FGFR/MEK/ERK/brachyury pathway is critical for chordoma cell growth and survival.Molecular profiling of chordoma.Molecular characterization of chordoma xenografts generated from a novel primary chordoma cell source and two chordoma cell linesPrimary intestinal and vertebral chordomas in laboratory zebrafish (Danio rerio).Characterization of T gene sequence variants and germline duplications in familial and sporadic chordoma.FAS/FASL are dysregulated in chordoma and their loss-of-function impairs zebrafish notochord formation.Investigating microenvironmental regulation of human chordoma cell behaviourDifficulty distinguishing benign notochordal cell tumor from chordoma further suggests a link between them.Chordomas at High Prevalence in the Captive Population of the Endangered Perdido Key Beach Mouse (Peromyscus polionotus trissyllepsis).
P2860
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P2860
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@ast
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@en
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@en-gb
type
label
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@ast
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@en
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@en-gb
prefLabel
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@ast
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@en
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@en-gb
P2093
P2860
P50
P356
P1433
P1476
T (brachyury) gene duplication confers major susceptibility to familial chordoma.
@en
P2093
Alisa M Goldstein
David A Alcorta
Dilys M Parry
Eamonn Sheridan
Xiaohong R Yang
P2860
P2888
P304
P356
10.1038/NG.454
P407
P577
2009-10-04T00:00:00Z