A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling. - sprookjes - yvandenbroek - TriplyDB

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

http://www.wikidata.org/entity/Q33281479

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A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans Nucleoporin translocated promoter region (Tpr) associates with dynein complex, preventing chromosome lagging formation during mitosis.The tumor suppressor CYLD regulates entry into mitosis Interlaboratory reproducibility of large-scale human protein-complex analysis by standardized AP-MS Linking kinetochore-microtubule binding to the spindle checkpoint Spred1 and TESK1--two new interaction partners of the kinase MARKK/TAO1 that link the microtubule and actin cytoskeleton Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK Cyclebase 3.0: a multi-organism database on cell-cycle regulation and phenotypes The nucleoporin Nup153 has separable roles in both early mitotic progression and the resolution of mitosis Tao-1 is a negative regulator of microtubule plus-end growth.TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes.Cancer proliferation gene discovery through functional genomics.Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery.Automated microscopy for high-content RNAi screening Time-lapse imaging of mitosis after siRNA transfection.High-throughput screens in diploid cells identify factors that contribute to the acquisition of chromosomal instability Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects An RNA interference screen for identifying downstream effectors of the p53 and pRB tumour suppressor pathways involved in senescence.Nek2 targets the mitotic checkpoint proteins Mad2 and Cdc20: a mechanism for aneuploidy in cancer.The nuclear envelope environment and its cancer connections.The genetics of normal platelet reactivity.SON is a spliceosome-associated factor required for mitotic progression.Re-examination of siRNA specificity questions role of PICH and Tao1 in the spindle checkpoint and identifies Mad2 as a sensitive target for small RNAs.Defining genome maintenance pathways using functional genomic approaches RAD54 family translocases counter genotoxic effects of RAD51 in human tumor cells.A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response.Vigilance and validation: Keys to success in RNAi screening.Molecular physiology of SPAK and OSR1: two Ste20-related protein kinases regulating ion transport.Cdk1 phosphorylation of BubR1 controls spindle checkpoint arrest and Plk1-mediated formation of the 3F3/2 epitope.Protein kinases of the Hippo pathway: regulation and substrates.Reconstructing signal transduction pathways: challenges and opportunities.Target validation to biomarker development: focus on RNA interference.A genome-wide association study identifies three loci associated with mean platelet volume Tau-based treatment strategies in neurodegenerative diseases Studying chromosome instability in the mouse.The spindle assembly checkpoint in Caenorhabditis elegans: one who lacks Mad1 becomes mad one Identification of novel kinase targets for the treatment of estrogen receptor-negative breast cancer.Elevating the frequency of chromosome mis-segregation as a strategy to kill tumor cells.The phosphoproteome in regenerating protoplasts from Physcomitrella patens protonemata shows changes paralleling postembryonic development in higher plants.Spindle assembly checkpoint: the third decade.

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A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

http://www.wikidata.org/entity/Q33281479

description

2007 nî lūn-bûn

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2007 թուականի Ապրիլին հրատարակուած գիտական յօդուած

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2007 թվականի ապրիլին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

A functional genomic screen id ...... spindle-checkpoint signalling.

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A functional genomic screen id ...... spindle-checkpoint signalling.

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type

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A functional genomic screen id ...... spindle-checkpoint signalling.

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A functional genomic screen id ...... spindle-checkpoint signalling.

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A functional genomic screen id ...... spindle-checkpoint signalling.

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A functional genomic screen id ...... spindle-checkpoint signalling.

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Nature Cell Biology

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A functional genomic screen id ...... spindle-checkpoint signalling

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P2093

Anthony Liang

http://www.w3.org/2001/XMLSchema#string

Frank Stegmeier

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Jing Chen

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Mathew E Sowa

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Stephen J Elledge

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Viji M Draviam

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MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1

NEK2A interacts with MAD1 and possibly functions as a novel integrator of the spindle checkpoint signaling

Bub1 is required for kinetochore localization of BubR1, Cenp-E, Cenp-F and Mad2, and chromosome congression

Identification of a MAD2-binding protein, CMT2, and its role in mitosis.

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

Chfr acts with the p38 stress kinases to block entry to mitosis in mammalian cells

Structural activation of Mad2 in the mitotic spindle checkpoint: the two-state Mad2 model versus the Mad2 template model

The DNA damage response: putting checkpoints in perspective

Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38

Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochores

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556-564

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scholarly article

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10.1038/NCB1569

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5

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9

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Grzegorz Nalepa

Peter K. Sorger

Jeffrey W. Harper

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2007-04-08T00:00:00Z

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6404234

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1050578729

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17417629

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