Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding.
about
PA1 protein, a new competitive decelerator acting at more than one step to impede glucocorticoid receptor-mediated transactivationLXXLL peptide converts transportan 10 to a potent inducer of apoptosis in breast cancer cells.Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs)Research resource: modulators of glucocorticoid receptor activity identified by a new high-throughput screening assay.Discovering small-molecule estrogen receptor α/coactivator binding inhibitors: high-throughput screening, ligand development, and models for enhanced potency.Alternative inhibition of androgen receptor signaling: peptidomimetic pyrimidines as direct androgen receptor/coactivator disruptors.Probing the topological tolerance of multimeric protein interactions: evaluation of an estrogen/synthetic ligand for FK506 binding protein conjugate.The molecular mechanisms underlying the pharmacological actions of ER modulators: implications for new drug discovery in breast cancer.Glucocorticoid receptor cofactors as therapeutic targets.Noncanonical mechanisms to regulate nuclear receptor signaling.Selectively targeting estrogen receptors for cancer treatment.Estrogen receptor α/β-cofactor motif interactions; interplay of tyrosine 537/488 phosphorylation and LXXLL motifs.Small molecule inhibitors as probes for estrogen and androgen receptor actionMethylsulfonylnitrobenzoates, a new class of irreversible inhibitors of the interaction of the thyroid hormone receptor and its obligate coactivators that functionally antagonizes thyroid hormone.In silico discovery and validation of potent small-molecule inhibitors targeting the activation function 2 site of human oestrogen receptor αThe road less traveled: new views of steroid receptor action from the path of dose-response curves.A complex task? Direct modulation of transcription factors with small molecules.Synthesis of biphenyl proteomimetics as estrogen receptor-alpha coactivator binding inhibitors.Ubiquitylation of nuclear receptors: new linkages and therapeutic implications.Separate regions of glucocorticoid receptor, coactivator TIF2, and comodulator STAMP modify different parameters of glucocorticoid-mediated gene induction.Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor.Nuclear receptor coregulators as a new paradigm for therapeutic targeting.Beyond the ligand-binding pocket: targeting alternate sites in nuclear receptors.Similarities and differences between two modes of antagonism of the thyroid hormone receptor.Estrogen receptor alpha/co-activator interaction assay: TR-FRETInhibiting androgen receptor nuclear entry in castration-resistant prostate cancer.4,4'-Unsymmetrically substituted 3,3'-biphenyl alpha helical proteomimetics as potential coactivator binding inhibitors.Synthesis of a tetrasubstituted tetrahydronaphthalene scaffold for α-helix mimicry via a MgBr2-catalyzed Friedel-Crafts epoxide cycloalkylation.Perfluoro-tert-butyl Homoserine Is a Helix-Promoting, Highly Fluorinated, NMR-Sensitive Aliphatic Amino Acid: Detection of the Estrogen Receptor·Coactivator Protein-Protein Interaction by 19F NMR.Design, synthesis and conformational analyses of bifacial benzamide based foldamersStructure–activity relationship studies of miniproteins targeting the androgen receptor–coactivator interaction
P2860
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P2860
Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding.
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Blocking estrogen signaling af ...... receptor-coactivator binding.
@ast
Blocking estrogen signaling af ...... receptor-coactivator binding.
@en
type
label
Blocking estrogen signaling af ...... receptor-coactivator binding.
@ast
Blocking estrogen signaling af ...... receptor-coactivator binding.
@en
prefLabel
Blocking estrogen signaling af ...... receptor-coactivator binding.
@ast
Blocking estrogen signaling af ...... receptor-coactivator binding.
@en
P2093
P2860
P356
P1476
Blocking estrogen signaling af ...... receptor-coactivator binding.
@en
P2093
Alexander A Parent
Jillian R Gunther
John A Katzenellenbogen
P2860
P304
P356
10.1021/JM800698B
P407
P577
2008-09-12T00:00:00Z