Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. - sprookjes - yvandenbroek - TriplyDB

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

http://www.wikidata.org/entity/Q33382120

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Neurotrophic factor small-molecule mimetics mediated neuroregeneration and synaptic repair: emerging therapeutic modality for Alzheimer's disease Differential levels of p75NTR ectodomain in CSF and blood in patients with Alzheimer's disease: a novel diagnostic marker A small molecule p75(NTR) ligand protects neurogenesis after traumatic brain injury Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment Alzheimer amyloid beta inhibition of Eg5/kinesin 5 reduces neurotrophin and/or transmitter receptor function.Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AβPP(L/S) transgenic mice.Prostaglandin signaling suppresses beneficial microglial function in Alzheimer's disease models.A data-driven approach for evaluating multi-modal therapy in traumatic brain injury.A small molecule p75NTR ligand normalizes signalling and reduces Huntington's disease phenotypes in R6/2 and BACHD mice.Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer's disease.Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression.Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents.Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease.Neurogenic and neurotrophic effects of BDNF peptides in mouse hippocampal primary neuronal cell cultures The preclinical discovery of amyotrophic lateral sclerosis drugs.Novel p75 neurotrophin receptor ligand stabilizes neuronal calcium, preserves mitochondrial movement and protects against HIV associated neuropathogenesis Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease.Characterization of a novel adult murine immortalized microglial cell line and its activation by amyloid-beta Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival p75 reduces beta-amyloid-induced sympathetic innervation deficits in an Alzheimer's disease mouse model.Signaling through Rho GTPase pathway as viable drug target.The role of the p75 neurotrophin receptor in cholinergic dysfunction in Alzheimer's disease.Inhibition of GM3 synthase attenuates neuropathology of Niemann-Pick disease Type C. by affecting sphingolipid metabolism.Suppression of Alzheimer-associated inflammation by microglial prostaglandin-E2 EP4 receptor signaling.Targeting synaptic dysfunction in Alzheimer's disease therapy.Dynamic nature of the p75 neurotrophin receptor in response to injury and disease The p75 neurotrophin receptor: at the crossroad of neural repair and death.Neuroregeneration versus neurodegeneration: toward a paradigm shift in Alzheimer's disease drug discovery.G-Protein-Coupled Inwardly Rectifying Potassium (GIRK) Channel Activation by the p75 Neurotrophin Receptor Is Required for Amyloid β Toxicity.p75NTR antagonists attenuate photoreceptor cell loss in murine models of retinitis pigmentosa.ProNGF-p75NTR axis plays a proinflammatory role in inflamed joints: a novel pathogenic mechanism in chronic arthritis.Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo.Pretreatment of PC12 cells with 17β-estradiol prevents Aβ-induced down-regulation of CREB phosphorylation and prolongs inhibition of GSK-3β.Modulating Neurotrophin Receptor Signaling as a Therapeutic Strategy for Huntington's Disease.Glial scars are permeable to the neurotoxic environment of chronic stroke infarcts.Targeting the intracellular signaling "STOP" and "GO" pathways for the treatment of alcohol use disorders.Alzheimer's associated amyloid and tau deposition co-localizes with a homeostatic myelin repair pathway in two mouse models of post-stroke mixed dementia

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P2860

Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment.

http://www.wikidata.org/entity/Q33382120

description

2008 nî lūn-bûn

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2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած

@hyw

2008 թվականի նոյեմբերին հրատարակված գիտական հոդված

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2008年の論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年論文

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2008年论文

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name

Small molecule, non-peptide p7 ...... ation and synaptic impairment.

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Small molecule, non-peptide p7 ...... ation and synaptic impairment.

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type

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Small molecule, non-peptide p7 ...... ation and synaptic impairment.

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Small molecule, non-peptide p7 ...... ation and synaptic impairment.

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Small molecule, non-peptide p7 ...... ation and synaptic impairment.

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Small molecule, non-peptide p7 ...... ation and synaptic impairment.

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Small molecule, non-peptide p7 ...... ation and synaptic impairment.

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Frank M Longo

http://www.w3.org/2001/XMLSchema#string

Gerald G Fuller

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Hong Zhang

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Jayakumar Rajadas

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Juliet K Knowles

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Katrin Andreasson

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Laura A Moore

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Qian Wang

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Qun Lu

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Stephen M Massa

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P2860

A Oligomer-Induced Aberrations in Synapse Composition, Shape, and Density Provide a Molecular Basis for Loss of Connectivity in Alzheimer's Disease

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

Neurotrophin receptor interacting factor (NRIF) is an essential mediator of apoptotic signaling by the p75 neurotrophin receptor

Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth

Natural oligomers of the Alzheimer amyloid-beta protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway

Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death.

Calpain and caspase: can you tell the difference?

In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis.

Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling

Glycogen synthase kinase 3beta phosphorylates Alzheimer's disease-specific Ser396 of microtubule-associated protein tau by a sequential mechanism.

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10.1371/JOURNAL.PONE.0003604

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11

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Ottavio Arancio

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23446370

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