The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
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Proteins associated with the exon junction complex also control the alternative splicing of apoptotic regulatorsTwo mammalian MAGOH genes contribute to exon junction complex composition and nonsense-mediated decayMechanism of escape from nonsense-mediated mRNA decay of human beta-globin transcripts with nonsense mutations in the first exonThe dharma of nonsense-mediated mRNA decay in mammalian cellsNonsense-mediated mRNA decay: inter-individual variability and human diseaseAdult Deletion of SRF Increases Epileptogenesis and Decreases Activity-Induced Gene Expression.Crystal structure of the human eIF4AIII-CWC22 complex shows how a DEAD-box protein is inhibited by a MIF4G domainFunction and pathological implications of exon junction complex factor Y14Modulation of nonsense mediated decay by rapamycinCharacteristics of transposable element exonization within human and mouse.Genetic analysis of nuclear bodies: from nondeterministic chaos to deterministic order.Post-transcriptional regulation of 5-lipoxygenase mRNA expression via alternative splicing and nonsense-mediated mRNA decayExon junction complex subunits are required to splice Drosophila MAP kinase, a large heterochromatic geneThe exon junction complex controls transposable element activity by ensuring faithful splicing of the piwi transcript.The exon junction complex is required for definition and excision of neighboring introns in DrosophilaExon Junction Complexes Show a Distributional Bias toward Alternatively Spliced mRNAs and against mRNAs Coding for Ribosomal Proteins.Transcriptome-wide modulation of splicing by the exon junction complex.Cyclin-dependent kinase 12 increases 3' end processing of growth factor-induced c-FOS transcripts.Specific Y14 domains mediate its nucleo-cytoplasmic shuttling and association with spliced mRNARbm8a haploinsufficiency disrupts embryonic cortical development resulting in microcephaly.CWC22-dependent pre-mRNA splicing and eIF4A3 binding enables global deposition of exon junction complexes.Perispeckles are major assembly sites for the exon junction core complex.A New Mutation, hap1-2, Reveals a C Terminal Domain Function in AtMago Protein and Its Biological Effects in Male Gametophyte Development in Arabidopsis thaliana.Identification of hundreds of novel UPF1 target transcripts by direct determination of whole transcriptome stability.EJC core component MLN51 interacts with eIF3 and activates translation.Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathwaysThe spliceosome as a transposon sensor.NKAP is a novel RS-related protein that interacts with RNA and RNA binding proteins.NMD: RNA biology meets human genetic medicine.Assembly, disassembly and recycling: the dynamics of exon junction complexes.The mechanism of the second step of pre-mRNA splicing.Regulation of nonsense-mediated mRNA decay.Nonsense-mediated mRNA decay factor Upf2 exists in both the nucleoplasm and the cytoplasm.The exon junction complex: a lifelong guardian of mRNA fate.Depletion of RNA-binding protein RBM8A (Y14) causes cell cycle deficiency and apoptosis in human cells.A short conserved motif in ALYREF directs cap- and EJC-dependent assembly of export complexes on spliced mRNAsHarnessing short poly(A)-binding protein-interacting peptides for the suppression of nonsense-mediated mRNA decay.A specific set of exon junction complex subunits is required for the nuclear retention of unspliced RNAs in Caenorhabditis elegansThe Arabidopsis thaliana MHX gene includes an intronic element that boosts translation when localized in a 5' UTR intron.Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.
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The hierarchy of exon-junction complex assembly by the spliceosome explains key features of mammalian nonsense-mediated mRNA decay.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
The hierarchy of exon-junction ...... nonsense-mediated mRNA decay.
@ast
The hierarchy of exon-junction ...... nonsense-mediated mRNA decay.
@en
type
label
The hierarchy of exon-junction ...... nonsense-mediated mRNA decay.
@ast
The hierarchy of exon-junction ...... nonsense-mediated mRNA decay.
@en
prefLabel
The hierarchy of exon-junction ...... nonsense-mediated mRNA decay.
@ast
The hierarchy of exon-junction ...... nonsense-mediated mRNA decay.
@en
P2860
P1433
P1476
The hierarchy of exon-junction ...... nonsense-mediated mRNA decay.
@en
P2093
Andreas E Kulozik
Styliani Lamprinaki
P2860
P304
P356
10.1371/JOURNAL.PBIO.1000120
P407
P577
2009-05-26T00:00:00Z