Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.
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Specific in vivo knockdown of protein function by intrabodiesIntrabodies as neuroprotective therapeuticsModulating self-assembly of amyloidogenic proteins as a therapeutic approach for neurodegenerative diseases: strategies and mechanismsOligomer-targeting with a conformational antibody fragment promotes toxicity in Aβ-expressing flies.Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease.TGF-β induces TIAF1 self-aggregation via type II receptor-independent signaling that leads to generation of amyloid β plaques in Alzheimer's disease.Imaging multiple phases of neurodegeneration: a novel approach to assessing cell death in vivo.Physico-chemical determinants of soluble intrabody expression in mammalian cell cytoplasm.Heparin induces harmless fibril formation in amyloidogenic W7FW14F apomyoglobin and amyloid aggregation in wild-type protein in vitro.Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments.Differential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease.Structure-based design of conformation- and sequence-specific antibodies against amyloid β.Hsp31 Is a Stress Response Chaperone That Intervenes in the Protein Misfolding ProcessBifunctional Anti-Non-Amyloid Component α-Synuclein Nanobodies Are Protective In Situ.Aggregation formation in the polyglutamine diseases: protection at a cost?Evidence for prion-like mechanisms in several neurodegenerative diseases: potential implications for immunotherapyDeveloping intrabodies for the therapeutic suppression of neurodegenerative pathology.Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteinsAtaxin-3 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies.Structural, morphological, and functional diversity of amyloid oligomers.Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts.Recombinant Antibody Fragments for Neurodegenerative Diseases.Altered expression of carbonic anhydrase-related protein XI in neuronal cells expressing mutant ataxin-3.Early or late-stage anti-N-terminal Huntingtin intrabody gene therapy reduces pathological features in B6.HDR6/1 mice.Automatic quantitative analysis of experimental primary and secondary retinal neurodegeneration: implications for optic neuropathies.Aromatic small molecules remodel toxic soluble oligomers of amyloid beta through three independent pathwaysAntibody Therapy in Neurodegenerative DiseaseGLP-1 Analogue Liraglutide Attenuates Mutant Huntingtin-Induced Neurotoxicity by Restoration of Neuronal Insulin SignalingCharacterization of Inter- and Intramolecular Interactions of Amyloid Fibrils by AFM-Based Single-Molecule Force Spectroscopy
P2860
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P2860
Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity.
description
2009 nî lūn-bûn
@nan
2009 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Conformational targeting of fi ...... aggregation and cytotoxicity.
@ast
Conformational targeting of fi ...... aggregation and cytotoxicity.
@en
type
label
Conformational targeting of fi ...... aggregation and cytotoxicity.
@ast
Conformational targeting of fi ...... aggregation and cytotoxicity.
@en
prefLabel
Conformational targeting of fi ...... aggregation and cytotoxicity.
@ast
Conformational targeting of fi ...... aggregation and cytotoxicity.
@en
P2093
P2860
P1433
P1476
Conformational targeting of fi ...... aggregation and cytotoxicity.
@en
P2093
Anne Messer
Michael R Sierks
Zongjian Jia
P2860
P356
10.1371/JOURNAL.PONE.0005727
P407
P577
2009-05-28T00:00:00Z