Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport - sprookjes - yvandenbroek - TriplyDB

Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport

Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport

http://www.wikidata.org/entity/Q33476856

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Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples Novel 5' untranslated region directed blockers of iron-regulatory protein-1 dependent amyloid precursor protein translation: implications for down syndrome and Alzheimer's disease Iron and restless legs syndrome: treatment, genetics and pathophysiology.The biological function of the cellular prion protein: an update Paradoxical role of prion protein aggregates in redox-iron induced toxicity.Prion protein regulates iron transport by functioning as a ferrireductase.Redox control of prion and disease pathogenesis.Manganese upregulates cellular prion protein and contributes to altered stabilization and proteolysis: relevance to role of metals in pathogenesis of prion disease Iron content of ferritin modulates its uptake by intestinal epithelium: implications for co-transport of prions.Expression of prion protein in mouse erythroid progenitors and differentiating murine erythroleukemia cells.Instability of the octarepeat region of the human prion protein gene.Deficiency of prion protein induces impaired autophagic flux in neurons.The Functional Role of Prion Protein (PrPC) on Autophagy.Prion protein in Caenorhabditis elegans: Distinct models of anti-BAX and neuropathology.Primary blast-induced traumatic brain injury in rats leads to increased prion protein in plasma: a potential biomarker for blast-induced traumatic brain injury Combined EXAFS and DFT structure calculations provide structural insights into the 1:1 multi-histidine complexes of Cu(II) , Cu(I) , and Zn(II) with the tandem octarepeats of the mammalian prion protein Prion protein promotes kidney iron uptake via its ferrireductase activity.Prion protein expression and functional importance in skeletal muscle.The role of iron in prion disease and other neurodegenerative diseases Change in the characteristics of ferritin induces iron imbalance in prion disease affected brains.Hematological shift in goat kids naturally devoid of prion protein.Cellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle.A delicate balance: Iron metabolism and diseases of the brain.Prion Protein and Stage Specific Embryo Antigen 1 as Selection Markers to Enrich the Fraction of Murine Embryonic Stem Cell-Derived Cardiomyocytes Oligodendrocyte/type-2 astrocyte progenitor cells and glial-restricted precursor cells generate different tumor phenotypes in response to the identical oncogenes.A low-molecular-weight ferroxidase is increased in the CSF of sCJD cases: CSF ferroxidase and transferrin as diagnostic biomarkers for sCJD.New insights into metal interactions with the prion protein: EXAFS analysis and structure calculations of copper binding to a single octarepeat from the prion protein.Brain iron homeostasis: from molecular mechanisms to clinical significance and therapeutic opportunities The iron regulatory capability of the major protein participants in prevalent neurodegenerative disorders.Physiological Functions of the Cellular Prion Protein.Protein oxidative modifications in the ageing brain: consequence for the onset of neurodegenerative disease.Metal attenuating therapies in neurodegenerative disease.Iron in neurodegenerative disorders of protein misfolding: a case of prion disorders and Parkinson's disease.Review of studies that have used knockout mice to assess normal function of prion protein under immunological or pathophysiological stress.Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration.Prion protein and aging.The prion-ZIP connection: From cousins to partners in iron uptake.Endogenous prion protein attenuates experimentally induced colitis.In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution.Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases.

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P2860

Prion protein (PrP) knock-out mice show altered iron metabolism: a functional role for PrP in iron uptake and transport

http://www.wikidata.org/entity/Q33476856

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2009 nî lūn-bûn

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2009 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2009 թվականի հուլիսին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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Prion protein (PrP) knock-out ...... P in iron uptake and transport

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Prion protein (PrP) knock-out ...... P in iron uptake and transport

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Prion protein (PrP) knock-out ...... P in iron uptake and transport

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Prion protein (PrP) knock-out ...... P in iron uptake and transport

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Prion protein (PrP) knock-out ...... P in iron uptake and transport

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Ajay Singh

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Howard Meyerson

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Neena Singh

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Qingzhong Kong

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Robert B Petersen

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Xiu Luo

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P2860

Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal

Doppel-induced cerebellar degeneration in transgenic mice

PrP knock-out and PrP transgenic mice in prion research

Mice devoid of prion protein have cognitive deficits that are rescued by reconstitution of PrP in neurons

Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network

Balancing acts: molecular control of mammalian iron metabolism

The cellular prion protein PrP(c) is involved in the proliferation of epithelial cells and in the distribution of junction-associated proteins.

Abnormal brain iron homeostasis in human and animal prion disorders

Intracellular iron transport and storage: from molecular mechanisms to health implications.

Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis.

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