AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.
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Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficitsLysosomal dysfunction promotes cleavage and neurotoxicity of tau in vivoTau physiology and pathomechanisms in frontotemporal lobar degenerationEarly and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortexThe unfolded protein response protects from tau neurotoxicity in vivo.Expression of P301L-hTau in mouse MEC induces hippocampus-dependent memory deficit.Protein tau: prime cause of synaptic and neuronal degeneration in Alzheimer's disease.Cleavage of tau by asparagine endopeptidase mediates the neurofibrillary pathology in Alzheimer's disease.Pathology associated with AAV mediated expression of beta amyloid or C100 in adult mouse hippocampus and cerebellumTauopathy differentially affects cell adhesion molecules in mouse brain: early down-regulation of nectin-3 in stratum lacunosum moleculare.Caspase activation precedes and leads to tangles.The role of telomerase protein TERT in Alzheimer's disease and in tau-related pathology in vitro.Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathyGSK3 and Alzheimer's Disease: Facts and Fiction….Dendritic degeneration, neurovascular defects, and inflammation precede neuronal loss in a mouse model for tau-mediated neurodegeneration.Functional genomic screen and network analysis reveal novel modifiers of tauopathy dissociated from tau phosphorylation.Expression of 1N3R-Tau isoform inhibits cell proliferation by inducing S phase arrest in N2a cells.Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus.Delta-secretase cleaves amyloid precursor protein and regulates the pathogenesis in Alzheimer's diseaseGene Therapy Models of Alzheimer's Disease and Other Dementias.Viral-mediated expression of desmin mutants to create mouse models of myofibrillar myopathy.β2 adrenergic receptor, protein kinase A (PKA) and c-Jun N-terminal kinase (JNK) signaling pathways mediate tau pathology in Alzheimer disease models.Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase.Transgenic models of Alzheimer's disease: better utilization of existing models through viral transgenesis.MiR-26b, upregulated in Alzheimer's disease, activates cell cycle entry, tau-phosphorylation, and apoptosis in postmitotic neuronsEarly structural and functional defects in synapses and myelinated axons in stratum lacunosum moleculare in two preclinical models for tauopathy.Invited review: Animal models of tauopathies and their implications for research/translation into the clinic.Physiological and pathophysiological functions of cell cycle proteins in post-mitotic neurons: implications for Alzheimer's diseaseThe Amyloid Cascade Hypothesis in Alzheimer's Disease: It's Time to Change Our Mind.Modeling of tau-mediated synaptic and neuronal degeneration in Alzheimer's disease.Fractalkine activates NRF2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis.Lentiviral delivery of the human wild-type tau protein mediates a slow and progressive neurodegenerative tau pathology in the rat brain.GSK-3α/β kinases and amyloid production in vivo.Potentiating tangle formation reduces acute toxicity of soluble tau species in the rat.Cytotoxic Effects of Environmental Toxins on Human Glial Cells.Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms.Practical considerations for choosing a mouse model of Alzheimer's disease.Altered cell cycle-related gene expression in brain and lymphocytes from a transgenic mouse model of Alzheimer's disease [amyloid precursor protein/presenilin 1 (PS1)].mTOR-mediated hyperphosphorylation of tau in the hippocampus is involved in cognitive deficits in streptozotocin-induced diabetic mice.
P2860
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P2860
AAV-tau mediates pyramidal neurodegeneration by cell-cycle re-entry without neurofibrillary tangle formation in wild-type mice.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
AAV-tau mediates pyramidal neu ...... e formation in wild-type mice.
@ast
AAV-tau mediates pyramidal neu ...... e formation in wild-type mice.
@en
type
label
AAV-tau mediates pyramidal neu ...... e formation in wild-type mice.
@ast
AAV-tau mediates pyramidal neu ...... e formation in wild-type mice.
@en
prefLabel
AAV-tau mediates pyramidal neu ...... e formation in wild-type mice.
@ast
AAV-tau mediates pyramidal neu ...... e formation in wild-type mice.
@en
P2093
P2860
P50
P1433
P1476
AAV-tau mediates pyramidal neu ...... e formation in wild-type mice.
@en
P2093
Annelies Termont
Benoit Lechat
David Demedts
Herman Devijver
Peter Borghgraef
Robert K Filipkowski
Sebastian Kügler
Sophie Croes
P2860
P356
10.1371/JOURNAL.PONE.0007280
P407
P577
2009-10-01T00:00:00Z