Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress. - sprookjes - yvandenbroek - TriplyDB

Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.

Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.

http://www.wikidata.org/entity/Q33541382

about

Multiple ATR-Chk1 pathway proteins preferentially associate with checkpoint-inducing DNA substrates Human single-stranded DNA binding proteins are essential for maintaining genomic stability Structure of RPA32 bound to the N-terminus of SMARCAL1 redefines the binding interface between RPA32 and its interacting proteins Characterization of functional domains in human Claspin Modulation of DNA damage and repair pathways by human tumour viruses RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response Timeless links replication termination to mitotic kinase activation The DNA Damage Response: Making It Safe to Play with Knives Novel regulation of checkpoint kinase 1: Is checkpoint kinase 1 a good candidate for anti-cancer therapy?Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1 Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.More forks on the road to replication stress recovery Human CST promotes telomere duplex replication and general replication restart after fork stalling.The intra-S phase checkpoint protein Tof1 collaborates with the helicase Rrm3 and the F-box protein Dia2 to maintain genome stability in Saccharomyces cerevisiae.CRY2 and FBXL3 Cooperatively Degrade c-MYC.Targeting the DNA replication checkpoint by pharmacologic inhibition of Chk1 kinase: a strategy to sensitize APC mutant colon cancer cells to 5-fluorouracil chemotherapy Circadian transcriptome analysis in human fibroblasts from Hunter syndrome and impact of iduronate-2-sulfatase treatment.Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)Timeless functions independently of the Tim-Tipin complex to promote sister chromatid cohesion in normal human fibroblasts The fork and the kinase: a DNA replication tale from a CHK1 perspective.RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.Altered replication in human cells promotes DMPK (CTG)(n) · (CAG)(n) repeat instability And-1 coordinates with Claspin for efficient Chk1 activation in response to replication stress Bringing It All Together: Coupling Excision Repair to the DNA Damage Checkpoint.DNA mismatch repair and the DNA damage response.Human Tim-Tipin complex affects the biochemical properties of the replicative DNA helicase and DNA polymerases.Separation of intra-S checkpoint protein contributions to DNA replication fork protection and genomic stability in normal human fibroblasts Expression of PER, CRY, and TIM genes for the pathological features of colorectal cancer patients.Phosphorylation of CMG helicase and Tof1 is required for programmed fork arrest.DNA damage tolerance: a double-edged sword guarding the genome Molecular mechanisms of DNA replication checkpoint activation Circadian clock circuitry in colorectal cancer.Eukaryotic DNA damage checkpoint activation in response to double-strand breaks.Local and global functions of Timeless and Tipin in replication fork protection.The biological clock and the molecular basis of lysosomal storage diseases.Investigation of N-Terminal Phospho-Regulation of Uracil DNA Glycosylase Using Protein Semisynthesis.Impact of Age and Insulin-Like Growth Factor-1 on DNA Damage Responses in UV-Irradiated Human Skin.Prospects for the Use of ATR Inhibitors to Treat Cancer.Tipin functions in the protection against topoisomerase I inhibitor BRCA1-dependent Chk1 phosphorylation triggers partial chromatin disassociation of phosphorylated Chk1 and facilitates S-phase cell cycle arrest.

P2860

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P2860

Tipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.

http://www.wikidata.org/entity/Q33541382

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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JBC.M110.110304

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Journal of Biological Chemistry

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P2093

Keziban Unsal-Kaçmaz

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Marila Cordeiro-Stone

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Mary Grillo

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Michael G Kemp

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Robert T Abraham

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Seçil Yilmaz

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Stephanie L Smith-Roe

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Tae-Hong Kang

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William K Kaufmann

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P2860

Coupling of human circadian and cell cycles by the timeless protein.

MSH2 and ATR form a signaling module and regulate two branches of the damage response to DNA methylation

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

The F box protein Fbx6 regulates Chk1 stability and cellular sensitivity to replication stress

An alternative form of replication protein a prevents viral replication in vitro

Interaction between human MCM7 and Rad17 proteins is required for replication checkpoint signaling

Human Tim/Timeless-interacting protein, Tipin, is required for efficient progression of S phase and DNA replication checkpoint

Rpa4, a homolog of the 34-kilodalton subunit of the replication protein A complex

A naturally occurring human RPA subunit homolog does not support DNA replication or cell-cycle progression

An alternative form of replication protein a expressed in normal human tissues supports DNA repair

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16562-16571

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10.1074/JBC.M110.110304

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22

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285

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2010-03-15T00:00:00Z

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20233725

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phosphorylation

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2878033

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