G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation.
about
Dopamine D1-D2 receptor Heteromer-mediated calcium release is desensitized by D1 receptor occupancy with or without signal activation: dual functional regulation by G protein-coupled receptor kinase 2GRK2: multiple roles beyond G protein-coupled receptor desensitizationCrystal Structure of Arrestin-3 Reveals the Basis of the Difference in Receptor Binding Between Two Non-visual SubtypesGα(i/o)-coupled receptor-mediated sensitization of adenylyl cyclase: 40 years laterNeurotensin triggers dopamine D2 receptor desensitization through a protein kinase C and beta-arrestin1-dependent mechanism.Desensitized D2 autoreceptors are resistant to trafficking.Selective deletion of GRK2 alters psychostimulant-induced behaviors and dopamine neurotransmissionConstitutive phosphorylation by protein kinase C regulates D1 dopamine receptor signaling.Ligand-induced internalization and recycling of the human neuropeptide Y2 receptor is regulated by its carboxyl-terminal tail.Mutation of three residues in the third intracellular loop of the dopamine D2 receptor creates an internalization-defective receptorModification of cocaine self-administration by buspirone (buspar®): potential involvement of D3 and D4 dopamine receptors.Few residues within an extensive binding interface drive receptor interaction and determine the specificity of arrestin proteins.G Protein-coupled Receptor Kinases of the GRK4 Protein Subfamily Phosphorylate Inactive G Protein-coupled Receptors (GPCRs).Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptorRole of receptor-attached phosphates in binding of visual and non-visual arrestins to G protein-coupled receptors.GRK2 protein-mediated transphosphorylation contributes to loss of function of μ-opioid receptors induced by neuropeptide FF (NPFF2) receptors.Manipulation of very few receptor discriminator residues greatly enhances receptor specificity of non-visual arrestinsReversal of dopamine D2 agonist-induced inhibition of ventral tegmental area neurons by Gq-linked neurotransmitters is dependent on protein kinase C, G protein-coupled receptor kinase, and dynamin.Arrestin-dependent but G-protein coupled receptor kinase-independent uncoupling of D2-dopamine receptors.GRK2 Constitutively Governs Peripheral Delta Opioid Receptor ActivityHypothesis review: are clathrin-mediated endocytosis and clathrin-dependent membrane and protein trafficking core pathophysiological processes in schizophrenia and bipolar disorder?Synthetic biology with surgical precision: targeted reengineering of signaling proteins.Roles of phosphorylation-dependent and -independent mechanisms in the regulation of histamine H2 receptor by G protein-coupled receptor kinase 2.A switch in the neuromodulatory effects of dopamine in the oval bed nucleus of the stria terminalis associated with cocaine self-administration in ratsTargeting individual GPCRs with redesigned nonvisual arrestins.Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.A point mutation in the dynein heavy chain gene leads to striatal atrophy and compromises neurite outgrowth of striatal neurons.Dopamine negatively modulates the NCA ion channels in C. elegans.Dysbindin-1 modifies signaling and cellular localization of recombinant, human D₃ and D₂ receptors.
P2860
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P2860
G protein-coupled receptor kinase-2 constitutively regulates D2 dopamine receptor expression and signaling independently of receptor phosphorylation.
description
2009 nî lūn-bûn
@nan
2009 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@ast
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@en
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@nl
type
label
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@ast
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@en
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@nl
prefLabel
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@ast
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@en
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@nl
P2093
P2860
P921
P356
P1476
G protein-coupled receptor kin ...... y of receptor phosphorylation.
@en
P2093
Concetta Dipace
David R Sibley
Eneko Urizar
Yoon Namkung
P2860
P304
34103-34115
P356
10.1074/JBC.M109.055707
P407
P577
2009-10-08T00:00:00Z