Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease - sprookjes - yvandenbroek - TriplyDB

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

http://www.wikidata.org/entity/Q33589965

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Dysregulation of the autophagy-endolysosomal system in amyotrophic lateral sclerosis and related motor neuron diseases A comprehensive glossary of autophagy-related molecules and processes (2nd edition)Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection Imbalances in p97 co-factor interactions in human proteinopathy The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy Exome sequencing reveals VCP mutations as a cause of familial ALS Ring of Change: CDC48/p97 Drives Protein Dynamics at Chromatin Prion-like domains as epigenetic regulators, scaffolds for subcellular organization, and drivers of neurodegenerative disease Impaired Autophagy and Defective Mitochondrial Function: Converging Paths on the Road to Motor Neuron Degeneration Insights into muscle degeneration from heritable inclusion body myopathies Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis Potential mechanisms of progranulin-deficient FTLD From neurodevelopment to neurodegeneration: the interaction of neurofibromin and valosin-containing protein/p97 in regulation of dendritic spine formation Does a loss of TDP-43 function cause neurodegeneration?Cardiac-Restricted Expression of VCP/TER94 RNAi or Disease Alleles Perturbs Drosophila Heart Structure and Impairs Function.The homozygote VCP(R¹⁵⁵H/R¹⁵⁵H) mouse model exhibits accelerated human VCP-associated disease pathology Inactivation of VCP/ter94 suppresses retinal pathology caused by misfolded rhodopsin in Drosophila Altered Intersubunit Communication Is the Molecular Basis for Functional Defects of Pathogenic p97 Mutants A Cdc48p-associated factor modulates endoplasmic reticulum-associated degradation, cell stress, and ubiquitinated protein homeostasis Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8 Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome.Mutations in the Human AAA+ Chaperone p97 and Related Diseases TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets.Autophagosome dynamics in neurodegeneration at a glance A novel mutation in VCP causes Charcot-Marie-Tooth Type 2 disease Rare Manifestation of a c.290 C>T, p.Gly97Glu VCP Mutation Altered cofactor regulation with disease-associated p97/VCP mutations Control of p97 function by cofactor binding Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration The p97/VCP ATPase is critical in muscle atrophy and the accelerated degradation of muscle proteins A Fine Balance of Dietary Lipids Improves Pathology of a Murine Model of VCP-Associated Multisystem Proteinopathy Lysosome size, motility and stress response regulated by fronto-temporal dementia modifier TMEM106B A non-canonical role of the p97 complex in RIG-I antiviral signaling Boning up on autophagy: the role of autophagy in skeletal biology Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death

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Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease

http://www.wikidata.org/entity/Q33589965

description

2009 nî lūn-bûn

@nan

2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

@hy

2009年の論文

@ja

2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

Valosin-containing protein (VC ...... nd is disrupted in VCP disease

@ast

Valosin-containing protein (VC ...... nd is disrupted in VCP disease

@en

Valosin-containing protein

@nl

type

label

Valosin-containing protein (VC ...... nd is disrupted in VCP disease

@ast

Valosin-containing protein (VC ...... nd is disrupted in VCP disease

@en

Valosin-containing protein

@nl

prefLabel

Valosin-containing protein (VC ...... nd is disrupted in VCP disease

@ast

Valosin-containing protein (VC ...... nd is disrupted in VCP disease

@en

Valosin-containing protein

@nl

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Journal of Cell Biology

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Valosin-containing protein (VC ...... nd is disrupted in VCP disease

@en

P2093

Conrad C Weihl

http://www.w3.org/2001/XMLSchema#string

David Piwnica-Worms

http://www.w3.org/2001/XMLSchema#string

Erin Jackson

http://www.w3.org/2001/XMLSchema#string

Robert H Baloh

http://www.w3.org/2001/XMLSchema#string

Sara E Miller

http://www.w3.org/2001/XMLSchema#string

P2860

GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16

Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice

Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia

p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy

Sarcoplasmic redistribution of nuclear TDP-43 in inclusion body myositis

Rapamycin rescues TDP-43 mislocalization and the associated low molecular mass neurofilament instability

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.

RETRACTED: VMA21 deficiency causes an autophagic myopathy by compromising V-ATPase activity and lysosomal acidification

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875-888

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scholarly article

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10.1083/JCB.200908115

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6

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187

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Rodrigo A Fuentealba

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2009-12-01T00:00:00Z

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40686299

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20008565

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2806317

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