Targeting surface nucleolin with a multivalent pseudopeptide delays development of spontaneous melanoma in RET transgenic mice
about
Surface expressed nucleolin is constantly induced in tumor cells to mediate calcium-dependent ligand internalization.Targeting surface nucleolin with multivalent HB-19 and related Nucant pseudopeptides results in distinct inhibitory mechanisms depending on the malignant tumor cell typeNucleolin mediates the antiangiogenesis effect of the pseudopeptide N6LHuman anti-nucleolin recombinant immunoagent for cancer therapy.Evaluation of somatostatin and nucleolin receptors for therapeutic delivery in non-small cell lung cancer stem cells applying the somatostatin-analog DOTATATE and the nucleolin-targeting aptamer AS1411.Interplay between αvβ3 integrin and nucleolin regulates human endothelial and glioma cell migration.In vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.Nucleolin inhibits Fas ligand binding and suppresses Fas-mediated apoptosis in vivo via a surface nucleolin-Fas complex.Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression.Identification of nucleolin as a lipid-raft-dependent β1-integrin-interacting protein in A375 cell migration.Cell-surface nucleolin acts as a central mediator for carcinogenic, anti-carcinogenic, and disease-related ligands.A novel fully human anti-NCL immunoRNase for triple-negative breast cancer therapy.Phosphorylation and changes in the distribution of nucleolin promote tumor metastasis via the PI3K/Akt pathway in colorectal carcinoma.Epithelial-mesenchymal transition in human gastric cancer cell lines induced by TNF-α-inducing protein of Helicobacter pylori.The pseudopeptide HB-19 binds to cell surface nucleolin and inhibits angiogenesis.Multivalent pseudopeptides targeting cell surface nucleoproteins inhibit cancer cell invasion through tissue inhibitor of metalloproteinases 3 (TIMP-3) release.Angiogenesis biomarkers and their targeting ligands as potential targets for tumor angiogenesis.Multivalent cationic pseudopeptide polyplexes as a tool for cancer therapy.Targeted therapy of human glioblastoma via delivery of a toxin through a peptide directed to cell surface nucleolin.The Rules and Functions of Nucleocytoplasmic Shuttling Proteins.Anticancer activity and antibody-dependent cell-mediated cytotoxicity of novel anti-nucleolin antibodies.
P2860
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P2860
Targeting surface nucleolin with a multivalent pseudopeptide delays development of spontaneous melanoma in RET transgenic mice
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Targeting surface nucleolin wi ...... elanoma in RET transgenic mice
@ast
Targeting surface nucleolin wi ...... elanoma in RET transgenic mice
@en
type
label
Targeting surface nucleolin wi ...... elanoma in RET transgenic mice
@ast
Targeting surface nucleolin wi ...... elanoma in RET transgenic mice
@en
prefLabel
Targeting surface nucleolin wi ...... elanoma in RET transgenic mice
@ast
Targeting surface nucleolin wi ...... elanoma in RET transgenic mice
@en
P2093
P2860
P356
P1433
P1476
Targeting surface nucleolin wi ...... elanoma in RET transgenic mice
@en
P2093
Ara G Hovanessian
Bernard Krust
Diala El Khoury
Jean-Paul Briand
José Courty
Marylène Garcette
Masashi Kato
Renée Lengagne
Sandra Niro
Yamina Hamma-Kourbali
P2860
P2888
P356
10.1186/1471-2407-10-325
P407
P577
2010-06-24T00:00:00Z
P5875
P6179
1033146404