Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions
about
Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes(-)-Epigallocatechin gallate, a major constituent of green tea, poisons human type II topoisomerasesBioflavonoids as poisons of human topoisomerase II alpha and II betaDietary polyphenols as topoisomerase II poisons: B ring and C ring substituents determine the mechanism of enzyme-mediated DNA cleavage enhancementPSMB7 is associated with anthracycline resistance and is a prognostic biomarker in breast cancerStimulation of human 8-oxoguanine-DNA glycosylase by AP-endonuclease: potential coordination of the initial steps in base excision repairMyeloperoxidase Enhances Etoposide and Mitoxantrone-Mediated DNA Damage: A Target for Myeloprotection in Cancer ChemotherapyTopoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma.Tyrosyl-DNA-phosphodiesterases (TDP1 and TDP2).Analysis of RuvABC and RecG involvement in the escherichia coli response to the covalent topoisomerase-DNA complexAcidic pH induces topoisomerase II-mediated DNA damage.Etoposide quinone is a redox-dependent topoisomerase II poisonEnzyme mechanism-based, oxidative DNA-protein cross-links formed with DNA polymerase β in vivoPosition-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents.Iron chelators with topoisomerase-inhibitory activity and their anticancer applications.Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2DNA topoisomerase II, genotoxicity, and cancerEpimerization of green tea catechins during brewing does not affect the ability to poison human type II topoisomerases.The DNA cleavage reaction of topoisomerase II: wolf in sheep's clothingDirect detection and quantification of abasic sites for in vivo studies of DNA damage and repair.Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalphaSmall-molecule inhibitors of proteins involved in base excision repair potentiate the anti-tumorigenic effect of existing chemotherapeutics and irradiation.Damage of DNA and proteins by major lipid peroxidation products in genome stability.Base excision repair intermediates as topoisomerase II poisons.The topoisomerase II poison clerocidin alkylates non-paired guanines of DNA: implications for irreversible stimulation of DNA cleavage.The anticancer thiosemicarbazones Dp44mT and triapine lack inhibitory effects as catalytic inhibitors or poisons of DNA topoisomerase IIα.Screening of Furanone in Cucurbita melo and Evaluation of its Bioactive Potential Using In Silico Studies.Etoposide quinone is a covalent poison of human topoisomerase IIβ.Enhanced processing of UVA-irradiated DNA by human topoisomerase II in living cells.Coordinating the two protomer active sites of human topoisomerase IIalpha: nicks as topoisomerase II poisons.Platinated DNA adducts enhance poisoning of DNA topoisomerase I by camptothecin.Physiological Roles of DNA Double-Strand Breaks.Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G.Molecular basis for the DNA damage induction and anticancer activity of asymmetrically substituted anthrapyridazone PDZ-7.Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.Mitochondrial tyrosyl-DNA phosphodiesterase 2 and its TDP2S short isoform.
P2860
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P2860
Sensitivity of human type II topoisomerases to DNA damage: stimulation of enzyme-mediated DNA cleavage by abasic, oxidized and alkylated lesions
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Sensitivity of human type II t ...... oxidized and alkylated lesions
@ast
Sensitivity of human type II t ...... oxidized and alkylated lesions
@en
type
label
Sensitivity of human type II t ...... oxidized and alkylated lesions
@ast
Sensitivity of human type II t ...... oxidized and alkylated lesions
@en
prefLabel
Sensitivity of human type II t ...... oxidized and alkylated lesions
@ast
Sensitivity of human type II t ...... oxidized and alkylated lesions
@en
P2860
P356
P1476
Sensitivity of human type II t ...... oxidized and alkylated lesions
@en
P2093
M Sabourin
N Osheroff
P2860
P304
P356
10.1093/NAR/28.9.1947
P407
P577
2000-05-01T00:00:00Z