Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases.
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P-loop conformation governed crizotinib resistance in G2032R-mutated ROS1 tyrosine kinase: clues from free energy landscapeUncovering Molecular Bases Underlying Bone Morphogenetic Protein Receptor Inhibitor SelectivityMolecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and CoevolutionInsight on Mutation-Induced Resistance from Molecular Dynamics Simulations of the Native and Mutated CSF-1R and KITPredictions of Ligand Selectivity from Absolute Binding Free Energy CalculationsBeyond Membrane Protein Structure: Drug Discovery, Dynamics and Difficulties.Computational study of Gleevec and G6G reveals molecular determinants of kinase inhibitor selectivity.LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients.Conformational analysis of the DFG-out kinase motif and biochemical profiling of structurally validated type II inhibitors.B-Cell Chronic Lymphocytic Leukemia with 11q22.3 Rearrangement in Patient with Chronic Myeloid Leukemia Treated with Imatinib.Constructing and Validating High-Performance MIEC-SVM Models in Virtual Screening for Kinases: A Better Way for Actives Discovery.miR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13.Evolution and intelligent design in drug development.Molecular modeling study of the induced-fit effect on kinase inhibition: the case of fibroblast growth factor receptor 3 (FGFR3).Small-world networks of residue interactions in the Abl kinase complexes with cancer drugs: topology of allosteric communication pathways can determine drug resistance effects.The opening/closure of the P-loop and hinge of BCR-ABL1 decodes the low/high bioactivities of dasatinib and axitinib.Structure-based de novo design and identification of D816V mutant-selective c-KIT inhibitors.Molecular principle of the cyclin-dependent kinase selectivity of 4-(thiazol-5-yl)-2-(phenylamino) pyrimidine-5-carbonitrile derivatives revealed by molecular modeling studies.Molecular Determinants of Substrate Affinity and Enzyme Activity of a Cytochrome P450 Variant
P2860
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P2860
Computational analysis of the binding specificity of Gleevec to Abl, c-Kit, Lck, and c-Src tyrosine kinases.
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Computational analysis of the ...... k, and c-Src tyrosine kinases.
@ast
Computational analysis of the ...... k, and c-Src tyrosine kinases.
@en
type
label
Computational analysis of the ...... k, and c-Src tyrosine kinases.
@ast
Computational analysis of the ...... k, and c-Src tyrosine kinases.
@en
prefLabel
Computational analysis of the ...... k, and c-Src tyrosine kinases.
@ast
Computational analysis of the ...... k, and c-Src tyrosine kinases.
@en
P2860
P356
P1476
Computational analysis of the ...... k, and c-Src tyrosine kinases.
@en
P2093
Benoît Roux
Yen-Lin Lin
P2860
P304
14741-14753
P356
10.1021/JA405939X
P407
P577
2013-09-20T00:00:00Z