Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy.
about
Roles of c-Met and RON kinases in tumor progression and their potential as therapeutic targetsThe RON receptor tyrosine kinase in pancreatic cancer pathogenesis and its potential implications for future targeted therapiesYhhu3813 is a novel selective inhibitor of c-Met kinase that inhibits c-Met-dependent neoplastic phenotypes of human cancer cellsHigh incidence of ErbB3, ErbB4, and MET expression in ovarian cancer.Deletion or insertion in the first immunoglobulin-plexin-transcription (IPT) domain differentially regulates expression and tumorigenic activities of RON receptor Tyrosine Kinase.Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine.Preclinical Efficacy of Ron Kinase Inhibitors Alone and in Combination with PI3K Inhibitors for Treatment of sfRon-Expressing Breast Cancer Patient-Derived Xenografts.Discovery of a new series of imidazo[1,2-a]pyridine compounds as selective c-Met inhibitors.Knockdown of RON receptor kinase delays but does not prevent tumor progression while enhancing HGF/MET signaling in pancreatic cancer cell lines.The RON receptor tyrosine kinase promotes metastasis by triggering MBD4-dependent DNA methylation reprogramming.Antibodies directed against receptor tyrosine kinases: current and future strategies to fight cancer.Recepteur d'origine nantais (RON), more than a kinase: Role in castrate-resistant prostate cancer.α-Ketobenzothiazole Serine Protease Inhibitors of Aberrant HGF/c-MET and MSP/RON Kinase Pathway Signaling in Cancer.Dramatic antitumor effects of the dual MET/RON small-molecule inhibitor LY2801653 in non-small cell lung cancer.The c-Met receptor: Implication for targeted therapies in colorectal cancer.Upregulation of recepteur d'origine nantais tyrosine kinase and cell invasiveness via early growth response-1 in gastric cancer cells.Analogs of the hepatocyte growth factor and macrophage-stimulating protein hinge regions act as Met and Ron dual inhibitors in pancreatic cancer cells.Roles of macrophage stimulating protein and tyrosine kinase receptor RON in smoke-induced airway inflammation of rats.Role of Recepteur D'origine Nantais on Gastric Cancer Development and ProgressionRON promotes the metastatic spread of breast carcinomas by subverting antitumor immune responses.RON Signaling Is a Key Mediator of Tumor Progression in Many Human Cancers.Expression and mutational status of RON in neoplastic lesions of the breast: analysis of MSP/RON signaling in ductal carcinoma in situ and invasive ductal carcinoma.RON is overexpressed in bladder cancer and contributes to tumorigenic phenotypes in 5637 cells.
P2860
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P2860
Potential therapeutics specific to c-MET/RON receptor tyrosine kinases for molecular targeting in cancer therapy.
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Potential therapeutics specifi ...... r targeting in cancer therapy.
@ast
Potential therapeutics specifi ...... r targeting in cancer therapy.
@en
type
label
Potential therapeutics specifi ...... r targeting in cancer therapy.
@ast
Potential therapeutics specifi ...... r targeting in cancer therapy.
@en
prefLabel
Potential therapeutics specifi ...... r targeting in cancer therapy.
@ast
Potential therapeutics specifi ...... r targeting in cancer therapy.
@en
P2093
P2860
P356
P1476
Potential therapeutics specifi ...... r targeting in cancer therapy.
@en
P2093
Ming-Hai Wang
Snehal S Padhye
Sunny Guin
Yong-qing Zhou
P2860
P2888
P304
P356
10.1038/APS.2010.106
P577
2010-08-09T00:00:00Z
P5875
P6179
1010645689