Chemoenzymatic design of heparan sulfate oligosaccharides
about
Glycosaminoglycans and glycomimetics in the central nervous systemBiological findings from the recent NMR-based studies of glycosaminoglycan-protein interactionsMasquerading microbial pathogens: capsular polysaccharides mimic host-tissue moleculesChemoenzymatic synthesis of heparan sulfate and heparinEngineering of routes to heparin and related polysaccharidesCan we produce heparin/heparan sulfate biomimetics using "mother-nature" as the gold standard?Using simple donors to drive the equilibria of glycosyltransferase-catalyzed reactionsChemoenzymatic synthesis of heparin oligosaccharides with both anti-factor Xa and anti-factor IIa activities.Molecular mechanism of substrate specificity for heparan sulfate 2-O-sulfotransferase.Chemoenzymatic synthesis and structural characterization of 2-O-sulfated glucuronic acid-containing heparan sulfate hexasaccharidesThe Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering ApplicationsChemoenzymatic synthesis of homogeneous ultralow molecular weight heparinsChemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains.Synthesis of a targeted library of heparan sulfate hexa- to dodecasaccharides as inhibitors of β-secretase: potential therapeutics for Alzheimer's disease.The dominating role of N-deacetylase/N-sulfotransferase 1 in forming domain structures in heparan sulfateComamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog.Enzymatic placement of 6-O-sulfo groups in heparan sulfateHomogeneous low-molecular-weight heparins with reversible anticoagulant activity.Structural characterization of heparins from different commercial sourcesDirecting the biological activities of heparan sulfate oligosaccharides using a chemoenzymatic approachChemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycansStructure/function analysis of Pasteurella multocida heparosan synthases: toward defining enzyme specificity and engineering novel catalysts.Role of Deacetylase Activity of N-Deacetylase/N-Sulfotransferase 1 in Forming N-Sulfated Domain in Heparan SulfateHeparin and related polysaccharides: synthesis using recombinant enzymes and metabolic engineering.Probing structural selectivity of synthetic heparin binding to Stabilin protein receptorsUncovering biphasic catalytic mode of C5-epimerase in heparan sulfate biosynthesisHeparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c.Deciphering mode of action of heparanase using structurally defined oligosaccharides.Toward a bioengineered heparin: challenges and strategies for metabolic engineering of mammalian cellsDivergent Synthesis of Heparan Sulfate Oligosaccharides.Investigation of the substrate specificity of K5 lyase A from K5A bacteriophageBioengineered heparins and heparan sulfates.Structurally informative tandem mass spectrometry of highly sulfated natural and chemoenzymatically synthesized heparin and heparan sulfate glycosaminoglycansPreparation and application of a 'clickable' acceptor for enzymatic synthesis of heparin oligosaccharidesStrategies in synthesis of heparin/heparan sulfate oligosaccharides: 2000-present.The design and synthesis of new synthetic low-molecular-weight heparins.An approach for separation and complete structural sequencing of heparin/heparan sulfate-like oligosaccharides.Harnessing glycomics technologies: integrating structure with function for glycan characterization.Perspectives on Anti-Glycan Antibodies Gleaned from Development of a Community Resource DatabaseFibroblast growth factor-based signaling through synthetic heparan sulfate blocks copolymers studied using high cell density three-dimensional cell printing
P2860
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P2860
Chemoenzymatic design of heparan sulfate oligosaccharides
description
2010 nî lūn-bûn
@nan
2010 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Chemoenzymatic design of heparan sulfate oligosaccharides
@ast
Chemoenzymatic design of heparan sulfate oligosaccharides
@en
type
label
Chemoenzymatic design of heparan sulfate oligosaccharides
@ast
Chemoenzymatic design of heparan sulfate oligosaccharides
@en
prefLabel
Chemoenzymatic design of heparan sulfate oligosaccharides
@ast
Chemoenzymatic design of heparan sulfate oligosaccharides
@en
P2093
P2860
P356
P1476
Chemoenzymatic design of heparan sulfate oligosaccharides
@en
P2093
Arlene S Bridges
Michel Weïwer
Paul L DeAngelis
Qisheng Zhang
Renpeng Liu
Xianxuan Zhou
Yongmei Xu
P2860
P304
34240-34249
P356
10.1074/JBC.M110.159152
P407
P577
2010-08-21T00:00:00Z