Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia - sprookjes - yvandenbroek - TriplyDB

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

http://www.wikidata.org/entity/Q33686199

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Transcription factor-mediated reprogramming toward hematopoietic stem cells CEBPA exerts a specific and biologically important proapoptotic role in pancreatic β cells through its downstream network targets Sox4 links tumor suppression to accelerated aging in mice by modulating stem cell activation Significance of oncogenes and tumor suppressor genes in AML prognosis.Disruption of the C/EBPα-miR-182 balance impairs granulocytic differentiation.The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia.C/EBPα is an essential collaborator in Hoxa9/Meis1-mediated leukemogenesis The multifaceted functions of C/EBPα in normal and malignant haematopoiesis.Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression.Hematopoietic Differentiation Is Required for Initiation of Acute Myeloid Leukemia.Identification of a dynamic core transcriptional network in t(8;21) AML that regulates differentiation block and self-renewal.SUMOylation of sPRDM16 promotes the progression of acute myeloid leukemia.The microRNA-212/132 cluster regulates B cell development by targeting Sox4.miR-132 inhibits lung cancer cell migration and invasion by targeting SOX4.C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO.Functional screen identifies regulators of murine hematopoietic stem cell repopulation Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia Myeloid differentiation and the leukemia-initiating cell Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction MicroRNA-140 Inhibits Cell Proliferation in Gastric Cancer Cell Line HGC-27 by Suppressing SOX4.SOX4 Promotes Progression in OLP-Associated Squamous Cell Carcinoma.LncSox4 promotes the self-renewal of liver tumour-initiating cells through Stat3-mediated Sox4 expression.The Wilms Tumor-1 (WT1) rs16754 polymorphism is a prognostic factor in acute myeloid leukemia (AML): a meta-analysis TMEM2 Is a SOX4-Regulated Gene That Mediates Metastatic Migration and Invasion in Breast Cancer C/EBPα in normal and malignant myelopoiesis.Targeted BMI1 inhibition impairs tumor growth in lung adenocarcinomas with low CEBPα expression.SOX12: a novel potential target for acute myeloid leukaemia.Developmental Control of NRAMP1 (SLC11A1) Expression in Professional Phagocytes Runx1 Structure and Function in Blood Cell Development.Exploring the utility of organo-polyoxometalate hybrids to inhibit SOX transcription factors.Molecular Mutations and Their Cooccurrences in Cytogenetically Normal Acute Myeloid Leukemia.TGF-β Tumor Suppression through a Lethal EMT.C/EBPα deregulation as a paradigm for leukemogenesis.Overexpression of SOX4 correlates with poor prognosis of acute myeloid leukemia and is leukemogenic in zebrafish Developmental-stage-dependent transcriptional response to leukaemic oncogene expression.EZH2-, CHD4-, and IDH-linked epigenetic perturbation and its association with survival in glioma patients.A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.SOX4 overexpression is a novel biomarker of malignant status and poor prognosis in breast cancer patients.Preleukemia and Leukemia-Initiating Cell Activity in inv(16) Acute Myeloid Leukemia.

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P2860

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

http://www.wikidata.org/entity/Q33686199

description

2013 nî lūn-bûn

@nan

2013 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2013 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2013年の論文

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2013年論文

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2013年論文

@zh-hant

2013年論文

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2013年論文

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2013年論文

@zh-tw

2013年论文

@wuu

name

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

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Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

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type

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Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

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Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

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prefLabel

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

@ast

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

@en

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J.CCR.2013.09.018

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Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia

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Alexander Ebralidze

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Annalisa Di Ruscio

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Claus Nerlov

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David T Scadden

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Elena Levantini

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Giovanni Amabile

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Henry Yang

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Hong Zhang

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Junyan Zhang

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Jörg Cammenga

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P2860

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-alpha (C/EBPalpha), in acute myeloid leukemia

Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration

Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4

Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation

A functional screen to identify novel effectors of hematopoietic stem cell activity

E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo

Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha

Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34(-) fraction.

Immortalization and leukemic transformation of a myelomonocytic precursor by retrovirally transduced HRX-ENL.

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575-588

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10.1016/J.CCR.2013.09.018

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5

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24

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Constanze Bonifer

Maarten Hoogenkamp

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2013-10-31T00:00:00Z

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258251567

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