HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation
about
Isolated Toll-like receptor transmembrane domains are capable of oligomerizationThe HIV-1 envelope transmembrane domain binds TLR2 through a distinct dimerization motif and inhibits TLR2-mediated responsesHIV-1 glycoprotein 41 ectodomain induces activation of the CD74 protein-mediated extracellular signal-regulated kinase/mitogen-activated protein kinase pathway to enhance viral infectionCholesterol-dependent membrane fusion induced by the gp41 membrane-proximal external region-transmembrane domain connection suggests a mechanism for broad HIV-1 neutralization.The secret life of viral entry glycoproteins: moonlighting in immune evasion.Conditional trimerization and lytic activity of HIV-1 gp41 variants containing the membrane-associated segments.Biophysical Characterization of a Vaccine Candidate against HIV-1: The Transmembrane and Membrane Proximal Domains of HIV-1 gp41 as a Maltose Binding Protein FusionThe Atomic Structure of the HIV-1 gp41 Transmembrane Domain and Its Connection to the Immunogenic Membrane-proximal External RegionHIV-1 gp41 transmembrane domain interacts with the fusion peptide: implication in lipid mixing and inhibition of virus-cell fusion.Rapid down-regulation of γc on T cells in early SIV infection correlates with impairment of T-cell function.An immunomodulating motif of the HIV-1 fusion protein is chirality-independent: implications for its mode of action.Evolution of immunity: no development without risk.Effects of HIV-1 gp41-Derived Virucidal Peptides on Virus-like Lipid Membranes.A GxxxG-like motif within HIV-1 fusion peptide is critical to its immunosuppressant activity, structure, and interaction with the transmembrane domain of the T-cell receptor.Drug efflux by a small multidrug resistance protein is inhibited by a transmembrane peptide.Role of the HIV-1 envelope transmembrane domain in intracellular sorting.The HTLV-1 gp21 fusion peptide inhibits antigen specific T-cell activation in-vitro and in mice.Gp41 dynamically interacts with the TCR in the immune synapse and promotes early T cell activation.
P2860
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P2860
HIV-1 gp41 and TCRalpha trans-membrane domains share a motif exploited by the HIV virus to modulate T-cell proliferation
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
HIV-1 gp41 and TCRalpha trans- ...... modulate T-cell proliferation
@ast
HIV-1 gp41 and TCRalpha trans- ...... modulate T-cell proliferation
@en
type
label
HIV-1 gp41 and TCRalpha trans- ...... modulate T-cell proliferation
@ast
HIV-1 gp41 and TCRalpha trans- ...... modulate T-cell proliferation
@en
prefLabel
HIV-1 gp41 and TCRalpha trans- ...... modulate T-cell proliferation
@ast
HIV-1 gp41 and TCRalpha trans- ...... modulate T-cell proliferation
@en
P2093
P2860
P1433
P1476
HIV-1 gp41 and TCRalpha trans- ...... modulate T-cell proliferation
@en
P2093
Irun R Cohen
Niv Antonovsky
Shmuel Jaffe Cohen
Tomer Cohen
Yechiel Shai
P2860
P304
P356
10.1371/JOURNAL.PPAT.1001085
P577
2010-09-02T00:00:00Z