Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.
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The Mcm2-7 replicative helicase: a promising chemotherapeutic targetRoles of DNA helicases in the maintenance of genome integrityA dominantly acting murine allele of Mcm4 causes chromosomal abnormalities and promotes tumorigenesisGenetic background affects induced pluripotent stem cell generationMinichromosome maintenance helicase paralog MCM9 is dispensible for DNA replication but functions in germ-line stem cells and tumor suppressionA reduction of licensed origins reveals strain-specific replication dynamics in miceThe MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.A concomitant loss of dormant origins and FANCC exacerbates genome instability by impairing DNA replication fork progression.MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity.Dynamic loading and redistribution of the Mcm2-7 helicase complex through the cell cycle.Schizosaccharomyces pombe minichromosome maintenance-binding protein (MCM-BP) antagonizes MCM helicase.Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.Rescue of replication failure by Fanconi anaemia proteins.MCM4 mutation causes adrenal failure, short stature, and natural killer cell deficiency in humans.Abundance of prereplicative complexes (Pre-RCs) facilitates recombinational repair under replication stress in fission yeastChronic DNA Replication Stress Reduces Replicative Lifespan of Cells by TRP53-Dependent, microRNA-Assisted MCM2-7 Downregulation.Post-transcriptional homeostasis and regulation of MCM2-7 in mammalian cells.Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.Comparative oncogenomics implicates the neurofibromin 1 gene (NF1) as a breast cancer driver.The presence of extra chromosomes leads to genomic instability.Aneuploidy in health, disease, and aging.Deregulated expression of Cdc6 in the skin facilitates papilloma formation and affects the hair growth cycle.Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.Simvastatin and Atorvastatin inhibit DNA replication licensing factor MCM7 and effectively suppress RB-deficient tumors growth.How dormant origins promote complete genome replication.Mechanisms and pathways of growth failure in primordial dwarfism.Scaffold/matrix attachment regions from CHO cell chromosome enhanced the stable transfection efficiency and the expression of transgene in CHO cells.Suppression of Reserve MCM Complexes Chemosensitizes to Gemcitabine and 5-Fluorouracil.Gata6 promotes hair follicle progenitor cell renewal by genome maintenance during proliferation.Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development.Dbf4 and Cdc7 proteins promote DNA replication through interactions with distinct Mcm2-7 protein subunits.A genome-wide screen to identify genes controlling the rate of entry into mitosis in fission yeastMcm2 deficiency results in short deletions allowing high resolution identification of genes contributing to lymphoblastic lymphoma.Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression.The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy.MCM9 deficiency delays primordial germ cell proliferation independent of the ATM pathway.Prognostic value of minichromosome maintenance mRNA expression in early-stage pancreatic ductal adenocarcinoma patients after pancreaticoduodenectomy
P2860
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P2860
Incremental genetic perturbations to MCM2-7 expression and subcellular distribution reveal exquisite sensitivity of mice to DNA replication stress.
description
2010 nî lūn-bûn
@nan
2010 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
Incremental genetic perturbati ...... ice to DNA replication stress.
@ast
Incremental genetic perturbati ...... ice to DNA replication stress.
@en
type
label
Incremental genetic perturbati ...... ice to DNA replication stress.
@ast
Incremental genetic perturbati ...... ice to DNA replication stress.
@en
prefLabel
Incremental genetic perturbati ...... ice to DNA replication stress.
@ast
Incremental genetic perturbati ...... ice to DNA replication stress.
@en
P2093
P2860
P1433
P1476
Incremental genetic perturbati ...... ice to DNA replication stress.
@en
P2093
Chen-Hua Chuang
Christian Abratte
John C Schimenti
Marsha D Wallace
Teresa Southard
P2860
P304
P356
10.1371/JOURNAL.PGEN.1001110
P577
2010-09-09T00:00:00Z