Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels.
about
Protein Kinase CK2: A Targetable BCR-ABL Partner in Philadelphia Positive LeukemiasThe relevance of PTEN-AKT in relation to NOTCH1-directed treatment strategies in T-cell acute lymphoblastic leukemiaA novel RON splice variant lacking exon 2 activates the PI3K/AKT pathway via PTEN phosphorylation in colorectal carcinoma cells.Posttranslational regulation of phosphatase and tensin homolog (PTEN) and its functional impact on cancer behaviors.The casein kinase 2 inhibitor, CX-4945, as an anti-cancer drug in treatment of human hematological malignancies.Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk leukemia.PTEN inhibits macrophage polarization from M1 to M2 through CCL2 and VEGF-A reduction and NHERF-1 synergism.CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target.Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leukemia.The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells.Casein kinase 2 controls the survival of normal thymic and leukemic γδ T cells via promotion of AKT signaling.Outlook on PI3K/AKT/mTOR inhibition in acute leukemia.Targeting mTOR for the treatment of B cell malignancies.Casein Kinase II (CK2), Glycogen Synthase Kinase-3 (GSK-3) and Ikaros mediated regulation of leukemia.Targeting CK2-driven non-oncogene addiction in B-cell tumors.New insights on thyroid hormone mediated regulation of herpesvirus infections.Pharmacological Rac1 inhibitors with selective apoptotic activity in human acute leukemic cell lines.Cancer-type dependent expression of CK2 transcripts.Therapeutic targeting of CK2 in acute and chronic leukemias.Phosphatidylinositol 3-kinase inhibition potentiates glucocorticoid response in B-cell acute lymphoblastic leukemia.The expression pattern of Bcl11a, Mdm2 and Pten genes in B-cell acute lymphoblastic leukemia.
P2860
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P2860
Adult B-cell acute lymphoblastic leukemia cells display decreased PTEN activity and constitutive hyperactivation of PI3K/Akt pathway despite high PTEN protein levels.
description
2014 nî lūn-bûn
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2014年の論文
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name
Adult B-cell acute lymphoblast ...... pite high PTEN protein levels.
@ast
Adult B-cell acute lymphoblast ...... pite high PTEN protein levels.
@en
type
label
Adult B-cell acute lymphoblast ...... pite high PTEN protein levels.
@ast
Adult B-cell acute lymphoblast ...... pite high PTEN protein levels.
@en
prefLabel
Adult B-cell acute lymphoblast ...... pite high PTEN protein levels.
@ast
Adult B-cell acute lymphoblast ...... pite high PTEN protein levels.
@en
P2093
P2860
P50
P1433
P1476
Adult B-cell acute lymphoblast ...... pite high PTEN protein levels.
@en
P2093
Aida B de Sousa
Ana Serra-Caetano
Joana Caldas
Maria V D Soares
Patrícia Ribeiro
Vanda Póvoa
P2860
P304
P356
10.3324/HAEMATOL.2013.096438
P577
2014-02-21T00:00:00Z