COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems. - sprookjes - yvandenbroek - TriplyDB

COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.

COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.

http://www.wikidata.org/entity/Q33703810

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Tumor stroma as targets for cancer therapy Deciphering Pro-Lymphangiogenic Programs during Mammary Involution and Postpartum Breast Cancer Breast cancer cell cyclooxygenase-2 expression alters extracellular matrix structure and function and numbers of cancer associated fibroblasts.Effect of Non-Steroidal Anti-Inflammatory Drugs on Bone Healing Abnormal COX2 protein expression may be correlated with poor prognosis in oral cancer: a meta-analysis.Effects of diclofenac and celecoxib on osteoclastogenesis during alveolar bone healing, in vivo.Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells.Cyclooxygenase-2-dependent lymphangiogenesis promotes nodal metastasis of postpartum breast cancer Microarray Analysis of Gene Expression Reveals that Cyclo-oxygenase-2 Gene Therapy Up-regulates Hematopoiesis and Down-regulates Inflammation During Endochondral Bone Fracture Healing.Apricoxib, a novel inhibitor of COX-2, markedly improves standard therapy response in molecularly defined models of pancreatic cancer.Chorionic gonadotrophin regulates CXCR4 expression in human endometrium via E-series prostanoid receptor 2 signalling to PI3K-ERK1/2: implications for fetal-maternal crosstalk for embryo implantation Selective activation of the prostaglandin E2 circuit in chronic injury-induced pathologic angiogenesis Pleiotropic effects of prostaglandin E2 in hematopoiesis; prostaglandin E2 and other eicosanoids regulate hematopoietic stem and progenitor cell function.Prostaglandins in cancer cell adhesion, migration, and invasion Epigenetics override pro-inflammatory PTGS transcriptomic signature towards selective hyperactivation of PGE2 in colorectal cancer Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice.Epigenetic silencing of HOPX promotes cancer progression in colorectal cancer.Effects of a selective cyclooxygenase-2 inhibitor (celecoxib) on fracture healing in rats.Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer.PGE(2)-induced CXCL12 production and CXCR4 expression controls the accumulation of human MDSCs in ovarian cancer environment.A study of prostaglandin pathway genes and interactions with current nonsteroidal anti-inflammatory drug use in colorectal adenoma.Eicosanoid profiling in an orthotopic model of lung cancer progression by mass spectrometry demonstrates selective production of leukotrienes by inflammatory cells of the microenvironment.Microvascular COX-2/mPGES-1/EP-4 axis in human abdominal aortic aneurysm.An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation CXCR2-expressing myeloid-derived suppressor cells are essential to promote colitis-associated tumorigenesis.HOXB13 mediates tamoxifen resistance and invasiveness in human breast cancer by suppressing ERα and inducing IL-6 expression.In pursuit of new anti-angiogenic therapies for cancer treatment COX-2 in cancer: Gordian knot or Achilles heel?Myeloid-Derived Suppressor Cells and Therapeutic Strategies in Cancer.Crude Fucoidan Extracts Impair Angiogenesis in Models Relevant for Bone Regeneration and Osteosarcoma via Reduction of VEGF and SDF-1.Garcinol exhibits anti-proliferative activities by targeting microsomal prostaglandin E synthase-1 in human colon cancer cells.Prostanoid induces premetastatic niche in regional lymph nodes.Inflammation modulates expression of laminin in the central nervous system following ischemic injury.Celecoxib normalizes the tumor microenvironment and enhances small nanotherapeutics delivery to A549 tumors in nude mice.Prostaglandin E2 regulates pancreatic stellate cell activity via the EP4 receptor.Anastomotic leakage contributes to the risk for systemic recurrence in stage II colorectal cancer.Vascular endothelial growth factor receptor 1 signaling facilitates gastric ulcer healing and angiogenesis through the upregulation of epidermal growth factor expression on VEGFR1+CXCR4 + cells recruited from bone marrow.COX-2-dependent PGE(2) acts as a growth factor in mycosis fungoides (MF).Thromboxane A₂ receptor signaling facilitates tumor colonization through P-selectin-mediated interaction of tumor cells with platelets and endothelial cells.Role of COX-2 in lymphangiogenesis and restoration of lymphatic flow in secondary lymphedema.

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COX-2 and prostaglandin EP3/EP4 signaling regulate the tumor stromal proangiogenic microenvironment via CXCL12-CXCR4 chemokine systems.

http://www.wikidata.org/entity/Q33703810

description

2010 nî lūn-bûn

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2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

COX-2 and prostaglandin EP3/EP ...... XCL12-CXCR4 chemokine systems.

@ast

COX-2 and prostaglandin EP3/EP ...... XCL12-CXCR4 chemokine systems.

@en

type

label

COX-2 and prostaglandin EP3/EP ...... XCL12-CXCR4 chemokine systems.

@ast

COX-2 and prostaglandin EP3/EP ...... XCL12-CXCR4 chemokine systems.

@en

prefLabel

COX-2 and prostaglandin EP3/EP ...... XCL12-CXCR4 chemokine systems.

@ast

COX-2 and prostaglandin EP3/EP ...... XCL12-CXCR4 chemokine systems.

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The American Journal of Pathology

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COX-2 and prostaglandin EP3/EP ...... XCL12-CXCR4 chemokine systems.

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Hideaki Tamaki

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Hidefumi Kubo

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Hiroki Kamata

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Hiroshi Katoh

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Hiroyuki Sakagami

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Kanako Hosono

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Masahiko Watanabe

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Masataka Majima

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Shuh Narumiya

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Tatsunori Suzuki

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P2860

Involvement of chemokine receptors in breast cancer metastasis

Inflammation and cancer

A novel chemokine receptor for SDF-1 and I-TAC involved in cell survival, cell adhesion, and tumor development

CXCR7 (RDC1) promotes breast and lung tumor growth in vivo and is expressed on tumor-associated vasculature

COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo

Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues

Angiogenic effects of prostaglandin E2 are mediated by up-regulation of CXCR4 on human microvascular endothelial cells

Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer

Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

Cancer and the chemokine network

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1469-1483

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10.2353/AJPATH.2010.090607

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20110411

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