The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
about
PI3K/AKT/mTOR Pathway in AngiogenesisRho GTPase signalling in cell migrationRho GAPs and GEFs: controling switches in endothelial cell adhesionRoles of the PI3K/Akt pathway in Epstein-Barr virus-induced cancers and therapeutic implicationsSPECC1L deficiency results in increased adherens junction stability and reduced cranial neural crest cell delaminationInvolvement of the H1 Histamine Receptor, p38 MAP Kinase, Myosin Light Chains Kinase, and Rho/ROCK in Histamine-Induced Endothelial Barrier Dysfunction.Local VE-cadherin mechanotransduction triggers long-ranged remodeling of endothelial monolayers.The Rho-GEF Trio regulates a novel pro-inflammatory pathway through the transcription factor Ets2.Caveolin-1-eNOS signaling promotes p190RhoGAP-A nitration and endothelial permeability.Rac1 functions as a reversible tension modulator to stabilize VE-cadherin trans-interactionEndothelial permeability and VE-cadherin: a wacky comradeship.Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNFDifferential distribution of PI3K isoforms in spinal cord and dorsal root ganglia: potential roles in acute inflammatory painPI3K p110α isoform-dependent Rho GTPase Rac1 activation mediates H2S-promoted endothelial cell migration via actin cytoskeleton reorganizationAdaptors for disorders of the brain? The cancer signaling proteins NEDD9, CASS4, and PTK2B in Alzheimer's disease.Pyk2 phosphorylation of VE-PTP downstream of STIM1-induced Ca2+ entry regulates disassembly of adherens junctions.Biphasic modulation of paracellular claudin-5 expression in mouse brain endothelial cells is mediated through the phosphoinositide-3-kinase/AKT pathwaySimultaneous analysis of large-scale RNAi screens for pathogen entry.Dissecting the cell to nucleus, perinucleus and cytosol.Inhibition of Pyk2 blocks lung inflammation and injury in a mouse model of acute lung injuryIRGM1 enhances B16 melanoma cell metastasis through PI3K-Rac1 mediated epithelial mesenchymal transition.Regulation of adherens junction dynamics by phosphorylation switches.p120-Catenin prevents neutrophil transmigration independently of RhoA inhibition by impairing Src dependent VE-cadherin phosphorylation.Different phosphoinositide 3-kinase isoforms mediate carrageenan nociception and inflammationInhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivoRab5-mediated VE-cadherin internalization regulates the barrier function of the lung microvascular endothelium.RhoB controls endothelial barrier recovery by inhibiting Rac1 trafficking to the cell borderTNFα promotes CAR-dependent migration of leukocytes across epithelial monolayers.A critical role for phosphatidylinositol (3,4,5)-trisphosphate-dependent Rac exchanger 1 in endothelial junction disruption and vascular hyperpermeability.Proline-rich tyrosine kinase 2 via enhancing signal transducer and activator of transcription 3-dependent cJun expression mediates retinal neovascularizationPhosphoinositide 3-kinase p110δ promotes lumen formation through the enhancement of apico-basal polarity and basal membrane organization.Protein tyrosine kinase signaling in the mouse oocyte cortex during sperm-egg interactions and anaphase resumption.VE-cadherin: at the front, center, and sides of endothelial cell organization and function.Endothelial membrane reorganization during leukocyte extravasation.Similarities and differences in the regulation of leukocyte extravasation and vascular permeability.Recent insights into endothelial control of leukocyte extravasation.When the endothelium scores an own goal: endothelial cells actively augment metastatic extravasation through endothelial-mesenchymal transition.Endothelial CD2AP Binds the Receptor ICAM-1 To Control Mechanosignaling, Leukocyte Adhesion, and the Route of Leukocyte Diapedesis In Vitro.Emerging roles of RAC1 in treating lung cancer patients.Protein Interactions at Endothelial Junctions and Signaling Mechanisms Regulating Endothelial Permeability.
P2860
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P2860
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
description
2010 nî lūn-bûn
@nan
2010 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի մարտին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
@ast
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
@en
type
label
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
@ast
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
@en
prefLabel
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
@ast
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
@en
P2860
P356
P1476
The PI3K p110alpha isoform regulates endothelial adherens junctions via Pyk2 and Rac1.
@en
P2093
Bart Vanhaesebroeck
Robert J Cain
P2860
P304
P356
10.1083/JCB.200907135
P407
P50
P577
2010-03-01T00:00:00Z