Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.
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Accessing Nature's diversity through metabolic engineering and synthetic biologyRecent Advances in Understanding and Engineering Polyketide SynthesisSynthetic biology for pharmaceutical drug discoveryRational Control of Polyketide Extender Units by Structure-Based Engineering of a Crotonyl-CoA Carboxylase/Reductase in Antimycin BiosynthesisSynthetic biology approaches to fluorinated polyketidesBiosynthesis of Fluorinated Peptaibols Using a Site-Directed Building Block Incorporation Approach.Natural and engineered biosynthesis of fluorinated natural products.Evaluating nonpolar surface area and liquid chromatography/mass spectrometry response: an application for site occupancy measurements for enzyme intermediates in polyketide biosynthesis.Recent advances in natural product discovery.Where next for microbiome research?Chemical probes for the functionalization of polyketide intermediates.Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksABiosynthesis-driven structure-activity relationship study of premonensin-derivatives.Inversion of Extender Unit Selectivity in the Erythromycin Polyketide Synthase by Acyltransferase Domain Engineering.Using natural products for drug discovery: the impact of the genomics era.Harnessing natural product assembly lines: structure, promiscuity, and engineering.Reinvigorating natural product combinatorial biosynthesis with synthetic biologyEnzyme recruitment and its role in metabolic expansion.Functional systems with orthogonal dynamic covalent bonds.Recent advances in the biosynthesis of unusual polyketide synthase substrates.Recent advances in combinatorial biosynthesis for drug discoveryRecent advances in fluorination techniques and their anticipated impact on drug metabolism and toxicity.Synthetic biology advances for pharmaceutical production.Halogenase Engineering for the Generation of New Natural Product Analogues.Genetic engineering of modular PKSs: from combinatorial biosynthesis to synthetic biology.Biosynthesis of polyketides by trans-AT polyketide synthases.Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.Antibiotics/antimicrobials: systemic and local administration in the therapy of mild to moderately advanced periodontitis.New, non-quinone fluorogeldanamycin derivatives strongly inhibit Hsp90.Characterization of a SAM-dependent fluorinase from a latent biosynthetic pathway for fluoroacetate and 4-fluorothreonine formation in Nocardia brasiliensis.Natural production of fluorinated compounds and biotechnological prospects of the fluorinase enzyme.Bluegenics: Bioactive Natural Products of Medicinal Relevance and Approaches to Their Diversification.Reprogramming acyl carrier protein interactions of an Acyl-CoA promiscuous trans-acyltransferase.Elucidating the mechanism of fluorinated extender unit loading for improved production of fluorine-containing polyketides.Engineered Fluorine Metabolism and Fluoropolymer Production in Living Cells.Biosynthesis: Non-stick natural products.Engineered polyketides: Synergy between protein and host level engineering.Biocatalytic Total Synthesis of Ikarugamycin.Rewriting the Metabolic Blueprint: Advances in Pathway Diversification in Microorganisms.Accelerating the semisynthesis of alkaloid-based drugs through metabolic engineering.
P2860
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P2860
Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.
description
2013 nî lūn-bûn
@nan
2013 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Expanding the fluorine chemist ...... polyketide synthase pathways.
@ast
Expanding the fluorine chemist ...... polyketide synthase pathways.
@en
type
label
Expanding the fluorine chemist ...... polyketide synthase pathways.
@ast
Expanding the fluorine chemist ...... polyketide synthase pathways.
@en
prefLabel
Expanding the fluorine chemist ...... polyketide synthase pathways.
@ast
Expanding the fluorine chemist ...... polyketide synthase pathways.
@en
P2093
P2860
P356
P1433
P1476
Expanding the fluorine chemist ...... d polyketide synthase pathways
@en
P2093
Brian Lowry
Chaitan Khosla
Louise K Charkoudian
Michelle C Y Chang
P2860
P304
P356
10.1126/SCIENCE.1242345
P407
P577
2013-09-01T00:00:00Z