In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis - sprookjes - yvandenbroek - TriplyDB

In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis

In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis

http://www.wikidata.org/entity/Q33772163

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Heparan sulfate and heparin interactions with proteins Pathophysiology of heparan sulphate: many diseases, few drugs Towards understanding the roles of heparan sulfate proteoglycans in Alzheimer's disease Prion-like properties of Tau protein: the importance of extracellular Tau as a therapeutic target Accelerated resolution of AA amyloid in heparanase knockout mice is associated with matrix metalloproteases Structure and Expression of Different Serum Amyloid A (SAA) Variants and their Concentration-Dependent Functions During Host Insults Heparan sulfate accumulation with Abeta deposits in Alzheimer's disease and Tg2576 mice is contributed by glial cells.Role of heparanase on hepatic uptake of intestinal derived lipoprotein and fatty streak formation in mice.Heparin induces harmless fibril formation in amyloidogenic W7FW14F apomyoglobin and amyloid aggregation in wild-type protein in vitro.Divergent effect of glycosaminoglycans on the in vitro aggregation of serum amyloid A Ex vivo cultures of microglia from young and aged rodent brain reveal age-related changes in microglial function The heparan sulfate motif (GlcNS6S-IdoA2S)3, common in heparin, has a strict topography and is involved in cell behavior and disease.Noncerebral Amyloidoses: Aspects on Seeding, Cross-Seeding, and Transmission.Proteomic analysis of highly prevalent amyloid A amyloidosis endemic to endangered island foxes Mammalian heparanase: what is the message?Inhibition of glycosaminoglycan synthesis and protein glycosylation with WAS-406 and azaserine result in reduced islet amyloid formation in vitro.Heparan sulfate/heparin promotes transthyretin fibrillization through selective binding to a basic motif in the protein.Observations in APP bitransgenic mice suggest that diffuse and compact plaques form via independent processes in Alzheimer's disease.Heparanase powers a chronic inflammatory circuit that promotes colitis-associated tumorigenesis in mice.Heparan sulfate proteoglycans.Suppression of amyloid beta A11 antibody immunoreactivity by vitamin C: possible role of heparan sulfate oligosaccharides derived from glypican-1 by ascorbate-induced, nitric oxide (NO)-catalyzed degradation.In vivo molecular imaging of peripheral amyloidosis using heparin-binding peptides.Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis SPECT imaging of peripheral amyloid in mice by targeting hyper-sulfated heparan sulfate proteoglycans with specific scFv antibodies.Transgenic over-expression of mammalian heparanase delays prion disease onset and progression.Heparan sulfate and syndecan-1 are essential in maintaining murine and human intestinal epithelial barrier function Heparan sulfate proteoglycans mediate Aβ-induced oxidative stress and hypercontractility in cultured vascular smooth muscle cells Drug Insight: emerging therapies for amyloidosis.The workings of the amyloid diseases.Heparan sulphate biosynthesis and disease.Heparanase: one molecule with multiple functions in cancer progression.Animal models of human amyloidoses: are transgenic mice worth the time and trouble?Increased Granulocyte Heparanase Activity in Neutrophils from Patients with Lupus Nephritis and Idiopathic Membranous Nephropathy.Amyloid and the GI tract.Localized amyloids important in diseases outside the brain--lessons from the islets of Langerhans and the thoracic aorta.Review of eprodisate for the treatment of renal disease in AA amyloidosis.Pathophysiology and treatment of systemic amyloidosis.Immunoglobulin light chain amyloidosis.Heparan sulfate-related oligosaccharides in ternary complex formation with fibroblast growth factors 1 and 2 and their receptors.The effect of glycosaminoglycans (GAGs) on amyloid aggregation and toxicity.

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P2860

In vivo fragmentation of heparan sulfate by heparanase overexpression renders mice resistant to amyloid protein A amyloidosis

http://www.wikidata.org/entity/Q33772163

description

2005 nî lūn-bûn

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2005年の論文

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In vivo fragmentation of hepar ...... amyloid protein A amyloidosis

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Proceedings of the National Academy of Sciences of the United States of America

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In vivo fragmentation of hepar ...... amyloid protein A amyloidosis

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Eyal Zcharia

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Feng Gong

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Israel Vlodavsky

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Jin-Ping Li

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Martha L Escobar Galvis

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Robert Kisilevsky

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Shula Metzger

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Xiao Zhang

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P2860

Mammalian heparanase: gene cloning, expression and function in tumor progression and metastasis

Structure of a heparin-linked biologically active dimer of fibroblast growth factor

An important role of heparan sulfate proteoglycan (Perlecan) in a model system for the deposition and persistence of fibrillar A beta-amyloid in rat brain

Inhibition of amyloidosis using low-molecular-weight heparins

Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice

Renal agenesis in mice homozygous for a gene trap mutation in the gene encoding heparan sulfate 2-sulfotransferase

Targeted disruption of a murine glucuronyl C5-epimerase gene results in heparan sulfate lacking L-iduronic acid and in neonatal lethality

Defective heparan sulfate biosynthesis and neonatal lethality in mice lacking N-deacetylase/N-sulfotransferase-1

Temporal relationship between glycosaminoglycan accumulation and amyloid deposition during experimental amyloidosis. A histochemical study

Functions of cell surface heparan sulfate proteoglycans

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