Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
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The hope for an HIV vaccine based on induction of CD8+ T lymphocytes--a reviewBiologically-directed modeling reflects cytolytic clearance of SIV-infected cells in vivo in macaquesImmunogenicity of seven new recombinant yellow fever viruses 17D expressing fragments of SIVmac239 Gag, Nef, and Vif in Indian rhesus macaquesGagCM9-specific CD8+ T cells expressing limited public TCR clonotypes do not suppress SIV replication in vivoImpaired antibody response causes persistence of prototypic T cell-contained virusViral CTL escape mutants are generated in lymph nodes and subsequently become fixed in plasma and rectal mucosa during acute SIV infection of macaquesDistinct HIV-1 Escape Patterns Selected by Cytotoxic T Cells with Identical Epitope SpecificityImmune responses during spontaneous control of HIV and AIDS: what is the hope for a cure?HIV-1 Env associates with HLA-C free-chains at the cell membrane modulating viral infectivity.Going wild: lessons from naturally occurring T-lymphotropic lentivirusesHLA Alleles Associated with Delayed Progression to AIDS Contribute Strongly to the Initial CD8(+) T Cell Response against HIV-1.Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape.Post-infection immunodeficiency virus control by neutralizing antibodiesCD8+ T cells from SIV elite controller macaques recognize Mamu-B*08-bound epitopes and select for widespread viral variation.Induction of human immunodeficiency virus (HIV-1) envelope specific cell-mediated immunity by a non-homologous synthetic peptideAbundance of early functional HIV-specific CD8+ T cells does not predict AIDS-free survival time.The specificity and polymorphism of the MHC class I prevents the global adaptation of HIV-1 to the monomorphic proteasome and TAP.HLA-associated immune escape pathways in HIV-1 subtype B Gag, Pol and Nef proteins.Candidate vaccine sequences to represent intra- and inter-clade HIV-1 variation.Inhibition of adaptive immune responses leads to a fatal clinical outcome in SIV-infected pigtailed macaques but not vervet African green monkeys.Effective simian immunodeficiency virus-specific CD8+ T cells lack an easily detectable, shared characteristic.HIV vaccination: turning the spotlight on effector memory T cells as mucosal gatekeepers.CD8+ lymphocytes control viral replication in SIVmac239-infected rhesus macaques without decreasing the lifespan of productively infected cells.In vivo CD8+ T-cell suppression of siv viremia is not mediated by CTL clearance of productively infected cells.Broad, intense anti-human immunodeficiency virus (HIV) ex vivo CD8(+) responses in HIV type 1-infected patients: comparison with anti-Epstein-Barr virus responses and changes during antiretroviral therapy.In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques.Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239Infection with HIV-1.Resistance to replication of human immunodeficiency virus challenge in SCID-Hu mice engrafted with peripheral blood mononuclear cells of nonprogressors is mediated by CD8(+) T cells and associated with a proliferative response to p24 antigen.T-cell correlates of vaccine efficacy after a heterologous simian immunodeficiency virus challenge.CD8(+) lymphocytes from simian immunodeficiency virus-infected rhesus macaques recognize 14 different epitopes bound by the major histocompatibility complex class I molecule mamu-A*01: implications for vaccine design and testing.Induction of neutralizing antibodies and gag-specific cellular immune responses to an R5 primary isolate of human immunodeficiency virus type 1 in rhesus macaques.Role of CD8(+) lymphocytes in control of simian immunodeficiency virus infection and resistance to rechallenge after transient early antiretroviral treatmentEmergence and kinetics of simian immunodeficiency virus-specific CD8(+) T cells in the intestines of macaques during primary infection.Impairment of Gag-specific CD8(+) T-cell function in mucosal and systemic compartments of simian immunodeficiency virus mac251- and simian-human immunodeficiency virus KU2-infected macaques.Rapid appearance of secondary immune responses and protection from acute CD4 depletion after a highly pathogenic immunodeficiency virus challenge in macaques vaccinated with a DNA prime/Sendai virus vector boost regimen.The challenge of immune control of immunodeficiency virusCD8+ T-lymphocyte response to major immunodominant epitopes after vaginal exposure to simian immunodeficiency virus: too late and too little.Low CD8 T-cell proliferative potential and high viral load limit the effectiveness of therapeutic vaccination.Experimental depletion of CD8+ cells in acutely SIVagm-infected African Green Monkeys results in increased viral replication.
P2860
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P2860
Administration of an anti-CD8 monoclonal antibody interferes with the clearance of chimeric simian/human immunodeficiency virus during primary infections of rhesus macaques
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Administration of an anti-CD8 ...... infections of rhesus macaques
@ast
Administration of an anti-CD8 ...... infections of rhesus macaques
@en
type
label
Administration of an anti-CD8 ...... infections of rhesus macaques
@ast
Administration of an anti-CD8 ...... infections of rhesus macaques
@en
prefLabel
Administration of an anti-CD8 ...... infections of rhesus macaques
@ast
Administration of an anti-CD8 ...... infections of rhesus macaques
@en
P2093
P2860
P1433
P1476
Administration of an anti-CD8 ...... infections of rhesus macaques
@en
P2093
P2860
P304
P577
1998-01-01T00:00:00Z