about
Pentamidine binds to tRNA through non-specific hydrophobic interactions and inhibits aminoacylation and translationConjugation of benzylvanillin and benzimidazole structure improves DNA binding with enhanced antileukemic propertiesPolyamide-scorpion cyclam lexitropsins selectively bind AT-rich DNA independently of the nature of the coordinated metalMetal-catalyzed uncaging of DNA-binding agents in living cells†Electronic supplementary information (ESI) available: Synthesis and characterization of the studied molecules and required precursors. NMR, UV, and fluorescence spectra, titrations, contTheoretical study of molecular recognition by Hoechst 33258 derivatives.Netropsin improves survival from endotoxaemia by disrupting HMGA1 binding to the NOS2 promoter.Influence of temperature and interactions with ligands on dissociation of dsDNA and ligand-dsDNA complexes of various types of binding. An electrochemical study.Epigenetic changes induced by curcumin and other natural compounds.Characterization of a novel DNA minor-groove complex.A thiazole coumarin (TC) turn-on fluorescence probe for AT-base pair detection and multipurpose applications in different biological systems.Development of distamycin-related DNA binding anticancer drugs.Sequence-specific minor groove binding by bis-benzimidazoles: water molecules in ligand recognition.Bi and tri-substituted phenyl rings containing bisbenzimidazoles bind differentially with DNA duplexes: a biophysical and molecular simulation study.Phase I pharmacokinetic and pharmacodynamic study of SJG-136, a novel DNA sequence selective minor groove cross-linking agent, in advanced solid tumors.Excited state proton transfer of natural flavonoids and their chromophores in duplex and tetraplex DNAsExperimental and computational studies on the effects of valganciclovir as an antiviral drug on calf thymus DNA.Systematic synthetic and biophysical development of mixed sequence DNA binding agents.Melting thermodynamics of reversible DNA/ligand complexes at interfaces.Modeling anticancer drug-DNA interactions via mixed QM/MM molecular dynamics simulations.Sequence and length dependent thermodynamic differences in heterocyclic diamidine interactions at AT base pairs in the DNA minor groove.Inhibition of BRCA2 and Thymidylate Synthase Creates Multidrug Sensitive Tumor Cells via the Induction of Combined "Complementary Lethality".Antiparasitic compounds that target DNA.A high-throughput, high-resolution strategy for the study of site-selective DNA binding agents: analysis of a "highly twisted" benzimidazole-diamidine.Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli.A role for water molecules in DNA-ligand minor groove recognitionDimeric approaches to anti-cancer chemotherapeutics.Groove-binding unsymmetrical cyanine dyes for staining of DNA: syntheses and characterization of the DNA-binding.DNA recognition by synthetic constructs.RNA targeting by small molecules: Binding of protoberberine, benzophenanthridine and aristolochia alkaloids to various RNA structures.Binding to the DNA minor groove by heterocyclic dications: from AT-specific monomers to GC recognition with dimers.Regulation of transcription by synthetic DNA-bending agents.Directing topoisomerase I mediated DNA cleavage to specific sites by camptothecin tethered to minor- and major-groove ligands.Protein and drug interactions in the minor groove of DNA.Semi-automated high-throughput fluorescent intercalator displacement-based discovery of cytotoxic DNA binding agents from a large compound librarySynthesis, biological evaluation, and modeling of dimeric PPI analogues as novel DNA minor groove binders.Metal-catalyzed uncaging of DNA-binding agents in living cells.Ferrocene-Based Bioactive Bimetallic Thiourea Complexes: Synthesis and Spectroscopic Studies.Molecular docking of intercalators and groove-binders to nucleic acids using Autodock and Surflex.Evaluation of complexes of DNA duplexes and novel benzoxazoles or benzimidazoles by electrospray ionization mass spectrometry.Concentration-dependent inhibition of sheep erythrocyte ghost plasma membrane Ca2+-ATPase activity by Berenil.
P2860
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P2860
description
1999 nî lūn-bûn
@nan
1999 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
Synthetic DNA minor groove-binding drugs.
@ast
Synthetic DNA minor groove-binding drugs.
@en
type
label
Synthetic DNA minor groove-binding drugs.
@ast
Synthetic DNA minor groove-binding drugs.
@en
prefLabel
Synthetic DNA minor groove-binding drugs.
@ast
Synthetic DNA minor groove-binding drugs.
@en
P2093
P1476
Synthetic DNA minor groove-binding drugs.
@en
P2093
P356
10.1016/S0163-7258(99)00021-2
P577
1999-10-01T00:00:00Z