The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.
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Neuropharmacology of alcohol addictionGlutamatergic substrates of drug addiction and alcoholismmGluR5 antagonism attenuates methamphetamine reinforcement and prevents reinstatement of methamphetamine-seeking behavior in ratsNegative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic WindowGlutamatergic targets for new alcohol medicationsGlutamatergic transmission in drug reward: implications for drug addictionDifferential effects of chronic ethanol consumption and withdrawal on homer/glutamate receptor expression in subregions of the accumbens and amygdala of P ratsEthanol-Associated Changes in Glutamate Reward Neurocircuitry: A Minireview of Clinical and Preclinical Genetic Findings.Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescentsOperant ethanol self-administration in ethanol dependent mice.Cue-conditioned alcohol seeking in rats following abstinence: involvement of metabotropic glutamate 5 receptors.Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbensMetabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intakeEffects of the mGlu2/3 agonist LY379268 and the mGlu5 antagonist MTEP on ethanol seeking and reinforcement are differentially altered in rats with a history of ethanol dependenceRole of glutamate transporter 1 in the attenuation of alcohol intake.Cognitive effects of Group I metabotropic glutamate receptor ligands in the context of drug addiction.How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol.Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinkingMetabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.Implication of the purinergic system in alcohol use disorders.Ceftriaxone, a beta-lactam antibiotic, reduces ethanol consumption in alcohol-preferring rats.mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in ratsEffects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in ratsFrequency of alcohol consumption in humans; the role of metabotropic glutamate receptors and downstream signaling pathwaysmGlu receptors and drug addiction.Nucleus accumbens mGluR5-associated signaling regulates binge alcohol drinking under drinking-in-the-dark procedures.Group 1 mGlu-family proteins promote neuroadaptation to ethanol and withdrawal-associated hippocampal damage.Rodent models and mechanisms of voluntary binge-like ethanol consumption: Examples, opportunities, and strategies for preclinical research.Effects of mGlu1-receptor blockade on ethanol self-administration in inbred alcohol-preferring rats.Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats.Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice.Nonselective suppression of operant ethanol and sucrose self-administration by the mGluR7 positive allosteric modulator AMN082.Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actionsCue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEPNeuroscience of alcoholism: molecular and cellular mechanismsEffects of topiramate and other anti-glutamatergic drugs on the acute intoxicating actions of ethanol in mice: modulation by genetic strain and stress.Metabotropic glutamate receptor ligands as potential therapeutics for addictionThe Effect of mGluR5 Antagonism During Binge Drinkingon Subsequent Ethanol Intake in C57BL/6J Mice: Sex- and Age-Induced Differences
P2860
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P2860
The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice.
description
2005 nî lūn-bûn
@nan
2005 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
The mGluR5 antagonist MPEP sel ...... ministration in C57BL/6J mice.
@ast
The mGluR5 antagonist MPEP sel ...... ministration in C57BL/6J mice.
@en
type
label
The mGluR5 antagonist MPEP sel ...... ministration in C57BL/6J mice.
@ast
The mGluR5 antagonist MPEP sel ...... ministration in C57BL/6J mice.
@en
prefLabel
The mGluR5 antagonist MPEP sel ...... ministration in C57BL/6J mice.
@ast
The mGluR5 antagonist MPEP sel ...... ministration in C57BL/6J mice.
@en
P2093
P2860
P1433
P1476
The mGluR5 antagonist MPEP sel ...... dministration in C57BL/6J mice
@en
P2093
Amanda C Sharko
Jason P Schroeder
Jennie R Hillmann
Joyce Besheer
Michael F Miles
Rebekah A Stevenson
Veronique Lepoutre
P2860
P2888
P304
P356
10.1007/S00213-005-0217-Y
P577
2005-11-15T00:00:00Z
P5875
P6179
1018188718