BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells - sprookjes - yvandenbroek - TriplyDB

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

http://www.wikidata.org/entity/Q33806036

about

Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age?ATRA-induced cellular differentiation and CD38 expression inhibits acquisition of BCR-ABL mutations for CML acquired resistance Stochastic dynamics and the evolution of mutations in stem cells The SCLtTAxBCR-ABL transgenic mouse model closely reflects the differential effects of dasatinib on normal and malignant hematopoiesis in chronic phase-CML patients Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML.p53 loss promotes acute myeloid leukemia by enabling aberrant self-renewal.Rac2 GTPase deficiency depletes BCR-ABL+ leukemic stem cells and progenitors in vivo.Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F.Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues.Mapping cancer origins.Maintenance of leukemia-initiating cells is regulated by the CDK inhibitor Inca1 Treatment of chronic myelogenous leukemia by blocking cytokine alterations found in normal stem and progenitor cells A Limited Role for the Cell Cycle Regulator Cyclin A1 in Murine Leukemogenesis Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells.Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival C/EBPβ promotes BCR-ABL-mediated myeloid expansion and leukemic stem cell exhaustion.Altered microenvironmental regulation of leukemic and normal stem cells in chronic myelogenous leukemia Alternative approaches to eradicating the malignant clone in chronic myeloid leukemia: tyrosine-kinase inhibitor combinations and beyond.CD150(-) Side Population Defines Leukemia Stem Cells in a BALB/c Mouse Model of CML and Is Depleted by Genetic Loss of SIRT1 Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene.Cooperativity of imprinted genes inactivated by acquired chromosome 20q deletions Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.PP2A-activating drugs selectively eradicate TKI-resistant chronic myeloid leukemic stem cells.Discovery of survival factor for primitive chronic myeloid leukemia cells using induced pluripotent stem cells.Preclinical approaches in chronic myeloid leukemia: from cells to systems Insights into the stem cells of chronic myeloid leukemia.Chronic myeloid leukemia stem cells and developing therapies.Molecular pathology of tumor-initiating cells: lessons from Philadelphia chromosome-positive leukemia.Mouse models as tools to understand and study BCR-ABL1 diseases.Myeloproliferative neoplasm animal models Concise review: cancer cells escape from oncogene addiction: understanding the mechanisms behind treatment failure for more effective targeting.Epigenetic therapy of cancer stem and progenitor cells by targeting DNA methylation machineries.Phenotypic and Functional Alterations of Hematopoietic Stem and Progenitor Cells in an In Vitro Leukemia-Induced Microenvironment Cellular and Molecular Networks in Chronic Myeloid Leukemia: The Leukemic Stem, Progenitor and Stromal Cell Interplay.Combined inhibition of β-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo.A 'telomere-associated secretory phenotype' cooperates with BCR-ABL to drive malignant proliferation of leukemic cells.IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development.Loss of Cbl and Cbl-b ubiquitin ligases abrogates hematopoietic stem cell quiescence and sensitizes leukemic disease to chemotherapy.

P2860

Q27317353-63386250-40A9-4ECC-9130-1BE0B6AA980F Q28383732-21EB3E76-4E75-4839-890E-6B858FD445A2 Q28540033-4071CCFC-E401-4735-A2BF-1CB443BE9304 Q31017219-D95C999F-3859-4A1E-B841-5A3346D08290 Q33798573-F6C4E6A8-5DBD-41D5-8887-5D23A9B18439 Q33834587-6233875C-3A04-47A3-8CBA-3353DD8F78C9 Q33953631-0C3A0489-CD6F-45CC-A208-1F8A4E93F441 Q33997238-51C9E852-9726-4E53-96C0-2AE8E22BC791 Q34375134-EF7C41BD-A8A1-41F7-B35D-D21550CB171C Q34632798-F4125879-FB68-4088-A185-B3E6CFDC9EE7 Q34750582-EF3A2C17-7B6D-46BE-AE22-D6374E32CFA3 Q34797136-D0D3EA35-B614-418A-A545-B029B7F7351D Q35530730-1727E4B5-19E4-4537-8045-E3B571F18322 Q35627994-4D1B4CB5-0862-47A0-87B9-59CE23DA835D Q35665110-9726601B-A9CF-4F71-B21F-46C95E7E3E42 Q35669231-F673FF08-4FB0-4BE1-B5F6-8AFA99EF790E Q35776432-6B9AED15-5251-44AA-ADF6-2DD352A584B9 Q35864103-7B5FC154-5986-49F3-86EF-5A36752E728E Q35903505-4B09A065-31F1-424D-8E35-E82F58555D23 Q35931271-5F3C4E88-8658-4B8E-8A43-553F48EBD0F3 Q36463738-0F3945EB-57F7-4851-8CA6-C20FCBB036CF Q36525232-17569558-E15F-4F4C-8DD8-5D66352EDFBB Q36793471-FBCF6CDA-1A73-4104-B711-6264CA54AA89 Q36850854-B8F525B5-D240-4FEB-A452-FF784E49C816 Q37200863-85099BC0-4727-4851-9BD5-A9699FB79328 Q37214753-CDEAA480-5BA4-4254-9BAF-DAB5363A340B Q37676954-89828EF4-8ADF-4D23-A742-F37C61FA966C Q37791423-EC340D9D-ECB7-4D69-878B-D5DBC609481F Q37836936-31402878-37D3-41ED-8CFF-2E52050F3D67 Q37925098-F3B150D9-7A09-4E5C-BE8B-1402B1316340 Q37995194-F77BD754-C7B7-4011-8D06-B77A27932673 Q38046320-D3491E2A-CE9F-4738-8129-F481B7318A2D Q38187388-4699DEB5-A203-4ACE-8A34-FAD23D42C2F7 Q38332497-90ABFBFF-D0C6-459F-A8A4-B88B8CDA4B3D Q38715717-99598260-1429-4F68-9A84-C945A52B1711 Q38866390-74A9009E-9C99-4C09-A71A-135249D191EA Q38892306-144D149F-A3AA-4A80-BF20-B233197CC760 Q39017947-814BA2F4-CF64-4B59-BDFC-85462939EFCE Q39255906-60ED40D5-7B19-4DB0-A08E-77EF90037234 Q41076612-F60069BA-DDCD-41FE-8221-E270EDDCACC6

P2860

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

http://www.wikidata.org/entity/Q33806036

description

2010 nî lūn-bûn

@nan

2010 թուականի Յունուարին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի հունվարին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

@ast

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

@en

type

label

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

@ast

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

@en

prefLabel

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

@ast

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

@en

P1433

Q33806036-06797263-7ED0-4211-96BD-D36456FB3366

P1476

Q33806036-5C99D497-F4FE-4E66-AA34-7904421C0CB2

P2093

Q33806036-02B1492F-B7D4-4D07-8005-F5CA6D38DFD1

Q33806036-180D6CC2-1C53-4381-AA03-EE0CDE15CC61

Q33806036-1CB62109-B68C-4E6F-9257-D2D7AE485DB4

Q33806036-4E618479-0B33-4DE8-844F-DB5E909A004F

Q33806036-5E8EA325-91F1-4A70-A105-38C2CBB6A307

Q33806036-9C8F2A4F-10DA-4C7A-9EA4-610B0DCAEECA

Q33806036-A5B5BBCD-BC96-40FD-8C05-D1712E54D0A8

Q33806036-B7ACE003-FE1F-4348-AC14-6EE9A4441151

Q33806036-C477CE41-215F-46D9-A925-267A5434DC4C

Q33806036-C94336CB-C522-4C56-B8AF-5671B2B86CC6

P2860

Q33806036-06B8421A-4594-4982-96A8-04D2D572A923

Q33806036-15DBD81E-E0B5-4E97-B7ED-780BA41BDF71

Q33806036-19C5CA79-B1A5-42A4-866F-BBF2EEBF0BD2

Q33806036-1A2D404E-53CC-40E8-8C65-FCB47DA4814E

Q33806036-257E378C-E9CC-41DD-A772-D9AAA09CC2F7

Q33806036-26C14177-2AE3-47B1-85EE-DC321D4C1467

Q33806036-288939BF-1976-41C5-9168-5DBED3C808E3

Q33806036-403E1629-F457-4477-8066-676CF5C49463

Q33806036-495AC6A6-6A1E-45E9-AF1A-1505B564ABDB

Q33806036-4E4E1DB6-87C7-45A9-9A61-DB177C6400C8

P304

Q33806036-71DBBEE8-2455-4000-8900-32B52F4D8470

P31

Q33806036-3B11A109-5E0D-4B21-82C3-2EC2DEEE3050

P356

Q33806036-A7E03603-3944-47EB-8B10-56D6B55B4DF9

P407

Q33806036-0696D918-9150-4240-A011-694596F9FD3B

P433

Q33806036-DD7CF522-3789-4DC8-B064-3C179576BE10

P478

Q33806036-5739B813-0959-4226-948A-2EADBB16C481

P50

Q33806036-0F2359BB-688F-47AD-96F7-B8A4F48EE0B9

Q33806036-258EF36E-A499-4FAE-94AD-E162437A108D

Q33806036-4ED7BB4B-6A5E-490C-9AF3-68C2931564D9

Q33806036-591EA08B-F9BD-42DF-80AE-C49BAC66250A

Q33806036-822946F1-9E33-4566-A745-74C73FFDF19D

Q33806036-F29BE587-62FC-4615-A5A1-B40F6FB3DF38

P577

Q33806036-9F972C6B-B4FC-420B-9230-BF90CECCE84A

P5875

Q33806036-4F3433C0-DEE4-4A65-8E5D-5E77F89D42B7

P698

Q33806036-C353A35C-75DD-42B0-9024-9859A589B6AA

P932

Q33806036-58212E54-ED0A-4344-B4D0-7867341BAC48

P356

BLOOD-2009-04-215376

P1433

P1476

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

@en

P2093

Amy Wagers

http://www.w3.org/2001/XMLSchema#string

Ashley Hamilton

http://www.w3.org/2001/XMLSchema#string

Christian Elling

http://www.w3.org/2001/XMLSchema#string

Claudia S Huettner

http://www.w3.org/2001/XMLSchema#string

Lara Tickenbrock

http://www.w3.org/2001/XMLSchema#string

Martin Stehling

http://www.w3.org/2001/XMLSchema#string

Mirle Schemionek

http://www.w3.org/2001/XMLSchema#string

Nicole Bäumer

http://www.w3.org/2001/XMLSchema#string

Tilmann Spieker

http://www.w3.org/2001/XMLSchema#string

Ulrich Steidl

http://www.w3.org/2001/XMLSchema#string

P2860

Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

Nilotinib in imatinib-resistant CML and Philadelphia chromosome-positive ALL

Granulocyte-macrophage progenitors as candidate leukemic stem cells in blast-crisis CML

Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia

Imaging hematopoietic precursor division in real time.

Characterization of cancer stem cells in chronic myeloid leukaemia.

Identification of a myeloid committed progenitor as the cancer-initiating cell in acute promyelocytic leukemia.

BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells.

A stem cell molecular signature.

Targeting multiple kinase pathways in leukemic progenitors and stem cells is essential for improved treatment of Ph+ leukemia in mice.

P304

3185-3195

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1182/BLOOD-2009-04-215376

http://www.w3.org/2001/XMLSchema#string

P407

P433

16

http://www.w3.org/2001/XMLSchema#string

P478

115

http://www.w3.org/2001/XMLSchema#string

P50

Carsten Müller-Tidow

Steffen Koschmieder

Tessa L Holyoake

Joachim R Göthert

P577

2010-01-06T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

40869702

http://www.w3.org/2001/XMLSchema#string

P698

20053753

http://www.w3.org/2001/XMLSchema#string

P932

2858483

http://www.w3.org/2001/XMLSchema#string