Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel - sprookjes - yvandenbroek - TriplyDB

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

http://www.wikidata.org/entity/Q33814258

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The Nucleotide-Binding Sites of SUR1: A Mechanistic Model Molecular action of sulphonylureas on KATP channels: a real partnership between drugs and nucleotides Crystal structure of a heterodimeric ABC transporter in its inward-facing conformation Structural basis for allosteric cross-talk between the asymmetric nucleotide binding sites of a heterodimeric ABC exporter.Obligate coupling of CFTR pore opening to tight nucleotide-binding domain dimerization Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications New horizons in the treatment of cystic fibrosis.Glucose-induced electrical activities and insulin secretion in pancreatic islet β-cells are modulated by CFTR Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs.Conserved allosteric hot spots in the transmembrane domains of cystic fibrosis transmembrane conductance regulator (CFTR) channels and multidrug resistance protein (MRP) pumps.Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects.A single amino acid substitution in CFTR converts ATP to an inhibitory ligand.Optimization of the degenerated interfacial ATP binding site improves the function of disease-related mutant cystic fibrosis transmembrane conductance regulator (CFTR) channels.Modulation of CFTR gating by permeant ions.Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Identification of a novel post-hydrolytic state in CFTR gating.Molecular modelling and molecular dynamics of CFTR.Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.The CFTR ion channel: gating, regulation, and anion permeation Cysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeation The multidrug transporter Pdr5 on the 25th anniversary of its discovery: an important model for the study of asymmetric ABC transporters Vx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle.Conformational changes in the catalytically inactive nucleotide-binding site of CFTR.Nonequilibrium gating of CFTR on an equilibrium theme.Exploring conformational equilibria of a heterodimeric ABC transporter.R248G cystic fibrosis transmembrane conductance regulator mutation in three siblings presenting with recurrent acute pancreatitis and reproductive issues: a case series.Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.Mechanism of the ABC transporter ATPase domains: catalytic models and the biochemical and biophysical record.Altering intracellular pH reveals the kinetic basis of intraburst gating in the CFTR Cl- channel.Electrostatic tuning of the pre- and post-hydrolytic open states in CFTR Synergistic Potentiation of Cystic Fibrosis Transmembrane Conductance Regulator Gating by Two Chemically Distinct Potentiators, Ivacaftor (VX-770) and 5-Nitro-2-(3-Phenylpropylamino) Benzoate.The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR.New structural insights into the gating movements of CFTR On the mechanism of gating defects caused by the R117H mutation in cystic fibrosis transmembrane conductance regulator.Degenerate ABC composite site is stably glued together by trapped ATP.Cystic Fibrosis Transmembrane Conductance Regulator (CFTR): CLOSED AND OPEN STATE CHANNEL MODELS.CFTR is a mechanosensitive anion channel: a real stretch?Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.

P2860

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P2860

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

http://www.wikidata.org/entity/Q33814258

description

2010 nî lūn-bûn

@nan

2010 թուականի Մայիսին հրատարակուած գիտական յօդուած

@hyw

2010 թվականի մայիսին հրատարակված գիտական հոդված

@hy

2010年の論文

@ja

2010年論文

@yue

2010年論文

@zh-hant

2010年論文

@zh-hk

2010年論文

@zh-mo

2010年論文

@zh-tw

2010年论文

@wuu

name

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

@ast

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

@en

type

label

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

@ast

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

@en

prefLabel

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

@ast

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

@en

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The Journal of General Physiology

P1476

Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel

@en

P2093

Min Li

http://www.w3.org/2001/XMLSchema#string

Ming-Feng Tsai

http://www.w3.org/2001/XMLSchema#string

Tzyh-Chang Hwang

http://www.w3.org/2001/XMLSchema#string

P2860

H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

ABC transporters: the power to change

Structure, function, and evolution of bacterial ATP-binding cassette systems

Structural insights into ABC transporter mechanism

The ABC protein turned chloride channel whose failure causes cystic fibrosis

Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding

Flexibility in the ABC transporter MsbA: Alternating access with a twist.

CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).

The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter

P304

399-414

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scholarly article

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10.1085/JGP.201010399

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5

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135

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2010-05-01T00:00:00Z

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43345578

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20421370

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2860585

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