Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women. - sprookjes - yvandenbroek - TriplyDB

Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women.

Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women.

http://www.wikidata.org/entity/Q33826049

about

PTEX is an essential nexus for protein export in malaria parasites Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea Allelic diversity of the Plasmodium falciparum erythrocyte membrane protein 1 entails variant-specific red cell surface epitopes.Antibodies to a full-length VAR2CSA immunogen are broadly strain-transcendent but do not cross-inhibit different placental-type parasite isolates Relevant assay to study the adhesion of Plasmodium falciparum-infected erythrocytes to the placental epithelium.Strategies for designing and monitoring malaria vaccines targeting diverse antigens Surface antigens of Plasmodium falciparum-infected erythrocytes as immune targets and malaria vaccine candidates.Sequence polymorphism, segmental recombination and toggling amino acid residues within the DBL3X domain of the VAR2CSA placental malaria antigen.Platelet factor 4 and Duffy antigen required for platelet killing of Plasmodium falciparum.Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines.The Plasmodium falciparum erythrocyte invasion ligand Pfrh4 as a target of functional and protective human antibodies against malaria.Defining the antigenic diversity of Plasmodium falciparum apical membrane antigen 1 and the requirements for a multi-allele vaccine against malaria.Plasmodium falciparum variability and immune evasion proceed from antigenicity of consensus sequences from DBL6ε; generalization to all DBL from VAR2CSA.Induction of strain-transcendent antibodies to placental-type isolates with VAR2CSA DBL3 or DBL5 recombinant proteins.VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta The antibody response of pregnant Cameroonian women to VAR2CSA ID1-ID2a, a small recombinant protein containing the CSA-binding site CD14(hi)CD16+ monocytes phagocytose antibody-opsonised Plasmodium falciparum infected erythrocytes more efficiently than other monocyte subsets, and require CD16 and complement to do so Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response to Plasmodium falciparum VAR2CSA-Expressing Parasites.Identification of a Major Dimorphic Region in the Functionally Critical N-Terminal ID1 Domain of VAR2CSA.Increased sensitivity for detecting malaria parasites in human umbilical cord blood using scaled-up DNA preparation.An assay to probe Plasmodium falciparum growth, transmission stage formation and early gametocyte development Targets of antibodies against Plasmodium falciparum-infected erythrocytes in malaria immunity.HIV and co-infections.Antibody responses to Plasmodium falciparum and Plasmodium vivax blood-stage and sporozoite antigens in the postpartum period.A single point in protein trafficking by Plasmodium falciparum determines the expression of major antigens on the surface of infected erythrocytes targeted by human antibodies.Pre-clinical and clinical development of the first placental malaria vaccine.Severe malaria: what's new on the pathogenesis front?The case for PfEMP1-based vaccines to protect pregnant women against Plasmodium falciparum malaria.A new method for sequencing the hypervariable Plasmodium falciparum gene var2csa from clinical samples.Multiplexing detection of IgG against Plasmodium falciparum pregnancy-specific antigens.The exported chaperone Hsp70-x supports virulence functions for Plasmodium falciparum blood stage parasites.Risk factors for malaria and adverse birth outcomes in a prospective cohort of pregnant women resident in a high malaria transmission area of Papua New Guinea.PfEMP1 as a target of human immunity and a vaccine candidate against malaria.Quantitative Proteomic Profiling Reveals Novel Plasmodium falciparum Surface Antigens and Possible Vaccine Candidates.Evaluating antibody functional activity and strain-specificity of vaccine candidates for malaria in pregnancy using in vitro phagocytosis assays.Human antibodies activate complement against Plasmodium falciparum sporozoites, and are associated with protection against malaria in children.

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P2860

Evaluation of the antigenic diversity of placenta-binding Plasmodium falciparum variants and the antibody repertoire among pregnant women.

http://www.wikidata.org/entity/Q33826049

description

2010 nî lūn-bûn

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2010 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2010 թվականի փետրվարին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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P2860

Recombination hotspots and population structure in Plasmodium falciparum

The Structure of a Chondroitin Sulfate-binding Domain Important in Placental Malaria

Structure of the DBL3x domain of pregnancy-associated malaria protein VAR2CSA complexed with chondroitin sulfate A

Rifins: a second family of clonally variant proteins expressed on the surface of red cells infected with Plasmodium falciparum

Exported proteins required for virulence and rigidity of Plasmodium falciparum-infected human erythrocytes

Selective upregulation of a single distinctly structured var gene in chondroitin sulphate A-adhering Plasmodium falciparum involved in pregnancy-associated malaria

Genetic diversity and chloroquine selective sweeps in Plasmodium falciparum

Switches in expression of Plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes

Skeleton-binding protein 1 functions at the parasitophorous vacuole membrane to traffic PfEMP1 to the Plasmodium falciparum-infected erythrocyte surface

SURFIN is a polymorphic antigen expressed on Plasmodium falciparum merozoites and infected erythrocytes

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