Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies - sprookjes - yvandenbroek - TriplyDB

Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

http://www.wikidata.org/entity/Q33826844

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Infection Counter: Automated Quantification of in Vitro Virus Replication by Fluorescence Microscopy Human monoclonal antibodies to a novel cluster of conformational epitopes on HCV E2 with resistance to neutralization escape in a genotype 2a isolate A hepatitis C virus (HCV) vaccine comprising envelope glycoproteins gpE1/gpE2 derived from a single isolate elicits broad cross-genotype neutralizing antibodies in humans A new model to produce infectious hepatitis C virus without the replication requirement.Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner.Productive homologous and non-homologous recombination of hepatitis C virus in cell culture.Neutralizing antibodies in patients with chronic hepatitis C, genotype 1, against a panel of genotype 1 culture viruses: lack of correlation to treatment outcome.MicroRNA-122 antagonism against hepatitis C virus genotypes 1-6 and reduced efficacy by host RNA insertion or mutations in the HCV 5' UTR.Hypervariable region 1 differentially impacts viability of hepatitis C virus strains of genotypes 1 to 6 and impairs virus neutralization Efficient culture adaptation of hepatitis C virus recombinants with genotype-specific core-NS2 by using previously identified mutations.In vivo evaluation of the cross-genotype neutralizing activity of polyclonal antibodies against hepatitis C virus.Efficient infectious cell culture systems of the hepatitis C virus (HCV) prototype strains HCV-1 and H77.Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4 Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus.Neutralization resistance of hepatitis C virus can be overcome by recombinant human monoclonal antibodies Production and characterization of high-titer serum-free cell culture grown hepatitis C virus particles of genotype 1-6.SEC14L2 enables pan-genotype HCV replication in cell culture.Adaptive Mutations Enhance Assembly and Cell-to-Cell Transmission of a High-Titer Hepatitis C Virus Genotype 5a Core-NS2 JFH1-Based Recombinant.Robust full-length hepatitis C virus genotype 2a and 2b infectious cultures using mutations identified by a systematic approach applicable to patient strains.Efficient replication of genotype 3a and 4a hepatitis C virus replicons in human hepatoma cells.Applying antibody-sensitive hypervariable region 1-deleted hepatitis C virus to the study of escape pathways of neutralizing human monoclonal antibody AR5A.Substitutions at NS3 Residue 155, 156, or 168 of Hepatitis C Virus Genotypes 2 to 6 Induce Complex Patterns of Protease Inhibitor Resistance Hepatitis C virus-host interactions, replication, and viral assembly Highly efficient full-length hepatitis C virus genotype 1 (strain TN) infectious culture system.Cooperativity in virus neutralization by human monoclonal antibodies to two adjacent regions located at the amino terminus of hepatitis C virus E2 glycoprotein Combination treatment with hepatitis C virus protease and NS5A inhibitors is effective against recombinant genotype 1a, 2a, and 3a viruses.Hepatitis C Virus Genotype 1 to 6 Protease Inhibitor Escape Variants: In Vitro Selection, Fitness, and Resistance Patterns in the Context of the Infectious Viral Life Cycle.Sequence and structural analysis of 3' untranslated region of hepatitis C virus, genotype 3a, from pakistani isolates Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1).Adapted J6/JFH1-based Hepatitis C virus recombinants with genotype-specific NS4A show similar efficacies against lead protease inhibitors, alpha interferon, and a putative NS4A inhibitor.HVR1-mediated antibody evasion of highly infectious in vivo adapted HCV in humanised mice.A novel strategy to develop a robust infectious hepatitis C virus cell culture system directly from a clinical isolate Understanding the hepatitis C virus life cycle paves the way for highly effective therapies.Adaptive immunity to the hepatitis C virus.Development and application of hepatitis C reporter viruses with genotype 1 to 7 core-nonstructural protein 2 (NS2) expressing fluorescent proteins or luciferase in modified JFH1 NS5A.Neutralizing monoclonal antibodies against hepatitis C virus E2 protein bind discontinuous epitopes and inhibit infection at a postattachment step.Extracellular Interactions between Hepatitis C Virus and Secreted Apolipoprotein E.Experimental models of hepatitis B and C - new insights and progress Efficient Hepatitis C Virus Genotype 1b Core-NS5A Recombinants Permit Efficacy Testing of Protease and NS5A Inhibitors.Hypervariable region 1 shielding of hepatitis C virus is a main contributor to genotypic differences in neutralization sensitivity.

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Novel infectious cDNA clones of hepatitis C virus genotype 3a (strain S52) and 4a (strain ED43): genetic analyses and in vivo pathogenesis studies

http://www.wikidata.org/entity/Q33826844

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Novel infectious cDNA clones o ...... d in vivo pathogenesis studies

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Novel infectious cDNA clones o ...... d in vivo pathogenesis studies

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Novel infectious cDNA clones o ...... d in vivo pathogenesis studies

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Novel infectious cDNA clones o ...... d in vivo pathogenesis studies

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Novel infectious cDNA clones o ...... d in vivo pathogenesis studies

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Novel infectious cDNA clones o ...... d in vivo pathogenesis studies

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P1433

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Journal of Virology

P1476

Novel infectious cDNA clones o ...... d in vivo pathogenesis studies

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P2093

Benoit Callendret

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Christopher M Walker

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Heather B Eccleston

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Robert H Purcell

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Ronald E Engle

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Sugantha Govindarajan

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William Satterfield

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Yi-Ping Li

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P2860

Sequence analysis of the core gene of 14 hepatitis C virus genotypes

Long-term follow-up of chimpanzees inoculated with the first infectious clone for hepatitis C virus.

Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection

Sustained Dysfunction of Antiviral CD8+ T Lymphocytes after Infection with Hepatitis C Virus

Robust hepatitis C virus infection in vitro.

Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease.

Mutations that permit efficient replication of hepatitis C virus RNA in Huh-7 cells prevent productive replication in chimpanzees.

The clearance of hepatitis C virus infection in chimpanzees may not necessarily correlate with the appearance of acquired immunity

Production of infectious genotype 1a hepatitis C virus (Hutchinson strain) in cultured human hepatoma cells

Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras

P304

5277-5293

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scholarly article

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10.1128/JVI.02667-09

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P433

10

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P478

84

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Judith M Gottwein

Troels K Scheel

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2010-03-03T00:00:00Z

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41722055

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20200247

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2863810

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