Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells. - sprookjes - yvandenbroek - TriplyDB

Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.

Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.

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Eye development and retinogenesis CD248 facilitates tumor growth via its cytoplasmic domain.Key tumor suppressor genes inactivated by "greater promoter" methylation and somatic mutations in head and neck cancer.HES1, a target of Notch signaling, is elevated in canine osteosarcoma, but reduced in the most aggressive tumors A Bovine Lymphosarcoma Cell Line Infected with Theileria annulata Exhibits an Irreversible Reconfiguration of Host Cell Gene Expression.Nanoparticle-based delivery of siDCAMKL-1 increases microRNA-144 and inhibits colorectal cancer tumor growth via a Notch-1 dependent mechanism.Potential role of Notch signalling in CD34+ chronic myeloid leukaemia cells: cross-talk between Notch and BCR-ABL Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.Hes1 Increases the Invasion Ability of Colorectal Cancer Cells via the STAT3-MMP14 Pathway.In vivo antitumor activity of intratumoral fludarabine phosphate in refractory tumors expressing E. coli purine nucleoside phosphorylase.GATA-1 utilizes Ikaros and polycomb repressive complex 2 to suppress Hes1 and to promote erythropoiesis Hes1: a key role in stemness, metastasis and multidrug resistance.Quiescent fibroblasts are protected from proteasome inhibition-mediated toxicity HES-Mediated Repression of Pten in Caenorhabditis elegans.Hes1 triggers epithelial-mesenchymal transition (EMT)-like cellular marker alterations and promotes invasion and metastasis of nasopharyngeal carcinoma by activating the PTEN/AKT pathway.Notch receptor and effector expression in von Hippel-Lindau disease-associated central nervous system hemangioblastomas.Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK GANT61, a GLI inhibitor, sensitizes glioma cells to the temozolomide treatment.Guttiferone K impedes cell cycle re-entry of quiescent prostate cancer cells via stabilization of FBXW7 and subsequent c-MYC degradation BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells.The role of dimerisation and nuclear transport in the Hes1 gene regulatory network.Developmental pathways in colon cancer: crosstalk between WNT, BMP, Hedgehog and Notch.JARID1B Enables Transit between Distinct States of the Stem-like Cell Population in Oral Cancers MicroRNA-19 triggers epithelial-mesenchymal transition of lung cancer cells accompanied by growth inhibition.HES1 promotes metastasis and predicts poor survival in patients with colorectal cancer.Notch1 receptor regulates AKT protein activation loop (Thr308) dephosphorylation through modulation of the PP2A phosphatase in phosphatase and tensin homolog (PTEN)-null T-cell acute lymphoblastic leukemia cells.A knockdown of Maml1 that results in melanoma cell senescence promotes an innate and adaptive immune response.Novel cis-regulatory modules control expression of the Hairy and Enhancer of Split-1 (HES1) transcription factor in myoblasts.Transient arrest in a quiescent state allows ovarian cancer cells to survive suboptimal growth conditions and is mediated by both Mirk/dyrk1b and p130/RB2.Deubiquitinating enzymes regulate Hes1 stability and neuronal differentiation.Regulation of ERK and AKT pathways by hepatitis B virus X protein via the Notch1 pathway in hepatocellular carcinoma Differential expression of transcription factors and inflammation-, ROS-, and cell death-related genes in organotypic cultures in the modiolus, the organ of Corti and the stria vascularis of newborn rats.FXR1a-associated microRNP: A driver of specialized non-canonical translation in quiescent conditions.Notch signalling is off and is uncoupled from HES1 expression in Ewing's sarcoma.Upregulation of HES1 Promotes Cell Proliferation and Invasion in Breast Cancer as a Prognosis Marker and Therapy Target via the AKT Pathway and EMT Process.HES1 as an independent prognostic marker in esophageal squamous cell carcinoma.Noise in the Vertebrate Segmentation Clock Is Boosted by Time Delays but Tamed by Notch Signaling.The oncogenic effects of HES1 on salivary adenoid cystic carcinoma cell growth and metastasis.The developmental origin of brain tumours: a cellular and molecular framework.Targeting tumor cell plasticity by combined inhibition of NOTCH and MAPK signaling in colon cancer

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P2860

Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.

http://www.wikidata.org/entity/Q33831060

description

2009 nî lūn-bûn

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2009 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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name

Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.

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Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.

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Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.

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Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.

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Hijacking HES1: how tumors co-opt the anti-differentiation strategies of quiescent cells.

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J.MOLMED.2009.11.001

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Trends in Molecular Medicine

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Hilary A Coller

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Liyun Sang

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Role of Notch signaling in cell-fate determination of human mammary stem/progenitor cells

The Hallmarks of Cancer

Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression

Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif

Integrative genomic analyses on HES/HEY family: Notch-independent HES1, HES3 transcription in undifferentiated ES cells, and Notch-dependent HES1, HES5, HEY1, HEY2, HEYL transcription in fetal tissues, adult tissues, or cancer

Molecular signatures of proliferation and quiescence in hematopoietic stem cells

A new description of cellular quiescence

Mutations in the human Sonic Hedgehog gene cause holoprosencephaly

Notch signaling: from the outside in

Hedgehog signaling in animal development: paradigms and principles

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