NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis - sprookjes - yvandenbroek - TriplyDB

NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

http://www.wikidata.org/entity/Q33840418

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A comprehensive manually curated reaction map of RANKL/RANK-signaling pathway Structure of the Nuclear Factor B-inducing Kinase (NIK) Kinase Domain Reveals a Constitutively Active Conformation The LIM protein, Limd1, regulates AP-1 activation through an interaction with Traf6 to influence osteoclast development NIK stabilization in osteoclasts results in osteoporosis and enhanced inflammatory osteolysis.Methyl salicylate lactoside inhibits inflammatory response of fibroblast-like synoviocytes and joint destruction in collagen-induced arthritis in mice Translational studies in older men using testosterone to treat sarcopenia.FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner.Negative feedback in noncanonical NF-kappaB signaling modulates NIK stability through IKKalpha-mediated phosphorylation Anti-arthritic effects of magnolol in human interleukin 1β-stimulated fibroblast-like synoviocytes and in a rat arthritis model.NF-κB-inducing kinase is a key regulator of inflammation-induced and tumour-associated angiogenesis.Nuclear factor-kappaB inducing kinase is required for graft-versus-host disease.Cell-intrinsic role for NF-kappa B-inducing kinase in peripheral maintenance but not thymic development of Foxp3+ regulatory T cells in mice.Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies.NF-κB-inducing kinase increases renal tubule epithelial inflammation associated with diabetes NF-κB-Mediated Regulation of Osteoclastogenesis Role of NF-κB in the skeleton Carboxyl terminus of HSC70-interacting protein (CHIP) down-regulates NF-κB-inducing kinase (NIK) and suppresses NIK-induced liver injury NF-κB–inducing kinase plays an essential T cell–intrinsic role in graft-versus-host disease and lethal autoimmunity in mice NLRP12 provides a critical checkpoint for osteoclast differentiation Functional inhibition of osteoblastic cells in an in vivo mouse model of myeloid leukemia Dendritic cells require NIK for CD40-dependent cross-priming of CD8+ T cells Cytoplasmic hnRNPK interacts with GSK3β and is essential for the osteoclast differentiation.NIK prevents the development of hypereosinophilic syndrome-like disease in mice independent of IKKα activation RelB is the NF-kappaB subunit downstream of NIK responsible for osteoclast differentiation.Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice.Alternative NF-κB Regulates RANKL-Induced Osteoclast Differentiation and Mitochondrial Biogenesis via Independent Mechanisms The roles of the classical and alternative nuclear factor-kappaB pathways: potential implications for autoimmunity and rheumatoid arthritis.Osteoclasts-Key Players in Skeletal Health and Disease.Role of the NF-kappaB axis in immune modulation of osteoclasts and bone loss.Targeting intracellular signaling: a novel approach to vaccination.Regulation of Th17 cell differentiation and EAE induction by MAP3K NIK.A cell-intrinsic requirement for NF-κB-inducing kinase in CD4 and CD8 T cell memory.Targeting NF-kappaB: a promising molecular therapy in inflammatory arthritis.Glucocorticoids increase skeletal muscle NF-κB inducing kinase (NIK): links to muscle atrophy.MicroRNA-322 inhibits inflammatory cytokine expression and promotes cell proliferation in LPS-stimulated murine macrophages by targeting NF-κB1 (p50)Potent anti-inflammatory and antiproliferative effects of gambogic acid in a rat model of antigen-induced arthritis.Functions of nuclear factor kappaB in bone.NF-κB inducing kinase: a key regulator in the immune system and in cancer Non-canonical NF-κB signaling activation and regulation: principles and perspectives.

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NF-(kappa)B-inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis

http://www.wikidata.org/entity/Q33840418

description

2005 nî lūn-bûn

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2005 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2005 թվականի հունիսին հրատարակված գիտական հոդված

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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name

NF-(kappa)B-inducing kinase co ...... ties in inflammatory arthritis

@ast

NF-(kappa)B-inducing kinase co ...... ties in inflammatory arthritis

@en

type

label

NF-(kappa)B-inducing kinase co ...... ties in inflammatory arthritis

@ast

NF-(kappa)B-inducing kinase co ...... ties in inflammatory arthritis

@en

prefLabel

NF-(kappa)B-inducing kinase co ...... ties in inflammatory arthritis

@ast

NF-(kappa)B-inducing kinase co ...... ties in inflammatory arthritis

@en

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P1433

Journal of Clinical Investigation

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NF-(kappa)B-inducing kinase co ...... ties in inflammatory arthritis

@en

P2093

Amanda Hagen-Stapleton

http://www.w3.org/2001/XMLSchema#string

Hideki Kitaura

http://www.w3.org/2001/XMLSchema#string

Kunihiko Aya

http://www.w3.org/2001/XMLSchema#string

Muhammad Alhawagri

http://www.w3.org/2001/XMLSchema#string

Osami Kanagawa

http://www.w3.org/2001/XMLSchema#string

P2860

NF-kappa B in rheumatoid arthritis: a pivotal regulator of inflammation, hyperplasia, and tissue destruction

NF-kappaB regulation in the immune system

Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway

Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin

Lymphotoxin-alpha-deficient mice. Effects on secondary lymphoid organ development and humoral immune responsiveness

Osteoclast differentiation is impaired in the absence of inhibitor of kappa B kinase alpha

Signaling to NF-kappaB

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins.

Despite ubiquitous autoantigen expression, arthritogenic autoantibody response initiates in the local lymph node

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1848-1854

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scholarly article

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10.1172/JCI23763

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P433

7

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115

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Deborah V Novack

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2005-06-02T00:00:00Z

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15937549

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1142111

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