Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle
about
Aging of hematopoietic stem cells: DNA damage and mutations?DNA Damage Response in Hematopoietic Stem Cell AgeingTo wake up cancer stem cells, or to let them sleep, that is the questionGenetic and Epigenetic Mechanisms That Maintain Hematopoietic Stem Cell FunctionWhen stem cells grow old: phenotypes and mechanisms of stem cell agingFine-tuning the ubiquitin code at DNA double-strand breaks: deubiquitinating enzymes at workOxidative stress, bone marrow failure, and genome instability in hematopoietic stem cellsEpigenetic regulation of hematopoietic stem cell agingInflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow MicroenvironmentProgenitor cell dysfunctions underlie some diabetic complicationsAging-Induced Stem Cell Mutations as Drivers for Disease and CancerFrequent Somatic Mutation in Adult Intestinal Stem Cells Drives Neoplasia and Genetic Mosaicism during AgingAccumulation of DNA damage in the aged hematopoietic stem cell compartmentLoss of P2Y₁₄ results in an arresting response to hematological stressStem cell aging: mechanisms, regulators and therapeutic opportunities.Growth hormone receptor signaling is dispensable for HSC function and aging.Do DNA Double-Strand Breaks Drive Aging?Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9Long-term quiescent fibroblast cells transit into senescenceDeveloping ovarian cancer stem cell models: laying the pipeline from discovery to clinical intervention.Concise review: hematopoietic stem cell aging and the prospects for rejuvenationPotential relationship between inadequate response to DNA damage and development of myelodysplastic syndrome.DNA damage: a sensible mediator of the differentiation decision in hematopoietic stem cells and in leukemia.Switching roles: the functional plasticity of adult tissue stem cells.Replication stress is a potent driver of functional decline in ageing haematopoietic stem cellsEpigenetic Control of Stem Cell Potential during Homeostasis, Aging, and DiseaseExcessive proliferation and impaired function of primitive hematopoietic cells in bone marrow due to senescence post chemotherapy in a T cell acute lymphoblastic leukemia model.Increased DNA damage and repair deficiency in granulosa cells are associated with ovarian aging in rhesus monkey.Single-cell transcriptomic reconstruction reveals cell cycle and multi-lineage differentiation defects in Bcl11a-deficient hematopoietic stem cells.Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells.Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality.Reactive oxygen species contribute to dysfunction of bone marrow hematopoietic stem cells in aged C57BL/6 J mice.Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1.Stem Cell-Specific Mechanisms Ensure Genomic Fidelity within HSCs and upon Aging of HSCs.Identification of early myeloid progenitors as immunosuppressive cells.Repression of p53-target gene Bbc3/PUMA by MYSM1 is essential for the survival of hematopoietic multipotent progenitors and contributes to stem cell maintenance.TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia.Quantification of in vivo progenitor mutation accrual with ultra-low error rate and minimal input DNA using SIP-HAVA-seqIn vivo transduction of primitive mobilized hematopoietic stem cells after intravenous injection of integrating adenovirus vectorsEndogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2(-/-) Hematopoietic Stem and Progenitor Cells.
P2860
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P2860
Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle
description
2014 nî lūn-bûn
@nan
2014 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Quiescent hematopoietic stem c ...... red upon entry into cell cycle
@ast
Quiescent hematopoietic stem c ...... red upon entry into cell cycle
@en
type
label
Quiescent hematopoietic stem c ...... red upon entry into cell cycle
@ast
Quiescent hematopoietic stem c ...... red upon entry into cell cycle
@en
prefLabel
Quiescent hematopoietic stem c ...... red upon entry into cell cycle
@ast
Quiescent hematopoietic stem c ...... red upon entry into cell cycle
@en
P2093
P2860
P1433
P1476
Quiescent hematopoietic stem c ...... red upon entry into cell cycle
@en
P2093
Derrick J Rossi
Irving L Weissman
Isabel Beerman
Matthew A Inlay
P2860
P356
10.1016/J.STEM.2014.04.016
P407
P50
P577
2014-05-08T00:00:00Z