Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity. - sprookjes - yvandenbroek - TriplyDB

Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity.

Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity.

http://www.wikidata.org/entity/Q33876601

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Marine Antimicrobial Peptides: Nature Provides Templates for the Design of Novel Compounds against Pathogenic Bacteria Peptides and Peptidomimetics for Antimicrobial Drug Design Antiviral mechanisms of human defensins Cytokeratins mediate epithelial innate defense through their antimicrobial properties.Involvement of β-defensin 130 (DEFB130) in the macrophage microbicidal mechanisms for killing Plasmodium falciparum Perspectives for clinical use of engineered human host defense antimicrobial peptides Human beta-defensin 2 and beta-defensin 3 chimeric peptides reveal the structural basis of the pathogen specificity of their parent molecules.Effect of selectively introducing arginine and D-amino acids on the antimicrobial activity and salt sensitivity in analogs of human beta-defensins.Will new generations of modified antimicrobial peptides improve their potential as pharmaceuticals?N-terminus three residues deletion mutant of human beta-defensin 3 with remarkably enhanced salt-resistance.Structure-function analysis of Avian β-defensin-6 and β-defensin-12: role of charge and disulfide bridges.Design and activity of a cyclic mini-β-defensin analog: a novel antimicrobial tool.The emerging role of peptides and lipids as antimicrobial epidermal barriers and modulators of local inflammation.Cell-mediated reduction of human β-defensin 1: a major role for mucosal thioredoxin Structure-activity relations of myxinidin, an antibacterial peptide derived from the epidermal mucus of hagfish Peptide inhibitors against herpes simplex virus infections.Omics in laboratory medicine.Protein and oligonucleotide delivery systems for vaginal microbicides against viral STIs.Enabling cytoplasmic delivery and organelle targeting by surface modification of nanocarriers.Host defense peptide-derived privileged scaffolds for anti-infective drug discovery.Structural determinants of Neosartorya fischeri antifungal protein (NFAP) for folding, stability and antifungal activity.β-Defensins in the Fight against Helicobacter pylori.Chimeric beta-defensin analogs, including the novel 3NI analog, display salt-resistant antimicrobial activity and lack toxicity in human epithelial cell lines.Design of short membrane selective antimicrobial peptides containing tryptophan and arginine residues for improved activity, salt-resistance, and biocompatibility.Microbial Diseases of Bivalve Mollusks: Infections, Immunology and Antimicrobial Defense.Current insights into the role of human β-defensins in atopic dermatitis.Cyclic Peptides as Novel Therapeutic Microbicides: Engineering of Human Defensin Mimetics.Antimicrobial peptide coatings for hydroxyapatite: electrostatic and covalent attachment of antimicrobial peptides to surfaces.An ancestral host defence peptide within human β-defensin 3 recapitulates the antibacterial and antiviral activity of the full-length molecule.Host Antimicrobial Peptides in Bacterial Homeostasis and Pathogenesis of Disease.β-Defensin 1 plays a role in acute mucosal defense against Candida albicans.Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis.Peptide-lipid interactions: experiments and applications.Structural insights into and activity analysis of the antimicrobial peptide myxinidin.Activity of human beta defensin-1 and its motif against active and dormant Mycobacterium tuberculosis.Expression of recombinant HBD3 protein that reduces Mycobacterial infection capacity.Engineering of a linear inactive analog of human β-defensin 4 to generate peptides with potent antimicrobial activity.Recombinant expression, purification, and antimicrobial activity of a novel hybrid antimicrobial peptide LFT33.A novel cecropin B-derived peptide with antibacterial and potential anti-inflammatory properties

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P2860

Novel synthetic, salt-resistant analogs of human beta-defensins 1 and 3 endowed with enhanced antimicrobial activity.

http://www.wikidata.org/entity/Q33876601

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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Novel synthetic, salt-resistan ...... hanced antimicrobial activity.

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Antimicrobial Agents and Chemotherapy

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Novel synthetic, salt-resistan ...... hanced antimicrobial activity.

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Carlo Pedone

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Francesco Salvatore

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Gino Naclerio

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Giuseppe Castaldo

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Marco Cantisani

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Mariateresa Vitiello

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Massimiliano Galdiero

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Olga Scudiero

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Rosa Di Noto

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Stefania Galdiero

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P2860

Isolation and characterization of human beta -defensin-3, a novel human inducible peptide antibiotic

Structure determination of human and murine beta-defensins reveals structural conservation in the absence of significant sequence similarity

Construction and properties of a mutant of herpes simplex virus type 1 with glycoprotein H coding sequences deleted

Engineering disulfide bridges to dissect antimicrobial and chemotactic activities of human beta-defensin 3

The structure of human beta-defensin-2 shows evidence of higher order oligomerization

The NMR structure of human beta-defensin-2 reveals a novel alpha-helical segment

The structure of human beta-defensin-1: new insights into structural properties of beta-defensins

The solution structures of the human beta-defensins lead to a better understanding of the potent bactericidal activity of HBD3 against Staphylococcus aureus

Defensins: antimicrobial peptides of innate immunity

Identification of a novel, multifunctional beta-defensin (human beta-defensin 3) with specific antimicrobial activity. Its interaction with plasma membranes of Xenopus oocytes and the induction of macrophage chemoattraction

P304

2312-2322

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scholarly article

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10.1128/AAC.01550-09

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6

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54

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Jean-Jacques Cassiman

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2010-03-22T00:00:00Z

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20308372

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2876405

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