Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.
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Transient dynamics of Aβ contribute to toxicity in Alzheimer's diseaseInhibition of IAPP Aggregation and Toxicity by Natural Products and DerivativesA Redox-Active, Compact Molecule for Cross-Linking Amyloidogenic Peptides into Nontoxic, Off-Pathway Aggregates: In Vitro and In Vivo Efficacy and Molecular Mechanisms.Molecular investigations of protriptyline as a multi-target directed ligand in Alzheimer's diseaseStructure-mechanism-based engineering of chemical regulators targeting distinct pathological factors in Alzheimer's disease.Amyloid β-Protein Assembly: The Effect of Molecular Tweezers CLR01 and CLR03A rationally designed small molecule for identifying an in vivo link between metal-amyloid-β complexes and the pathogenesis of Alzheimer's disease.Ion mobility spectrometry: A personal view of its development at UCSBSynthetic Flavonoids, Aminoisoflavones: Interaction and Reactivity with Metal-Free and Metal-Associated Amyloid-β SpeciesNew multi-target-directed small molecules against Alzheimer's disease: a combination of resveratrol and clioquinol.Arresting amyloid with coulomb's law: acetylation of ALS-linked SOD1 by aspirin impedes aggregationTools of the trade: investigations into design strategies of small molecules to target components in Alzheimer's disease.Role of membrane biophysics in Alzheimer's-related cell pathways.Distinguishing of tumor cell-targeting peptide ligands through a color-encoding microarray.Rationally Designed CeNP@MnMoS4 Core-Shell Nanoparticles for Modulating Multiple Facets of Alzheimer's Disease.Amyloid β-Protein Assembly: Differential Effects of the Protective A2T Mutation and Recessive A2V Familial Alzheimer's Disease Mutation.Reactivity of Metal-Free and Metal-Associated Amyloid-β with Glycosylated Polyphenols and Their Esterified Derivatives.BODIPY-Based Fluorescent Probes for Sensing Protein Surface-Hydrophobicity.Opposing Effects of Cucurbit[7]uril and 1,2,3,4,6-Penta-O-galloyl-β-d-glucopyranose on Amyloid β25-35 Assembly.Discovery of novel PDE9 inhibitors capable of inhibiting Aβ aggregation as potential candidates for the treatment of Alzheimer's disease.Mechanism of C-Terminal Fragments of Amyloid β-Protein as Aβ Inhibitors: Do C-Terminal Interactions Play a Key Role in Their Inhibitory Activity?A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates.Metal complexes designed to bind to amyloid-β for the diagnosis and treatment of Alzheimer's disease.Recent progress in repositioning Alzheimer's disease drugs based on a multitarget strategy.Ultraviolet light triggers the conversion of Cu2+-bound Aβ42 aggregates into cytotoxic species in a copper chelation-independent manner.Sialic Acid Hydroxamate: A Potential Antioxidant and Inhibitor of Metal-Induced β-Amyloid Aggregates.A metal-based tumour necrosis factor-alpha converting enzyme inhibitor.Modulation of the Aβ peptide aggregation pathway by KP1019 limits Aβ-associated neurotoxicity.Anticholinesterase, antioxidant, analgesic and anti-inflammatory activity assessment of Xeranthemum annuum L. and isolation of two cyanogenic compounds.Role of Species-Specific Primary Structure Differences in Aβ42 Assembly and NeurotoxicityHeterocyclic compounds as key structures for the interaction with old and new targets in Alzheimer's disease therapy.Influence of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes.How Zn can impede Cu detoxification by chelating agents in Alzheimer's disease: a proof-of-concept study.Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease.Mutual interference of Cu and Zn ions in Alzheimer's disease: perspectives at the molecular level.A Near-Infrared Responsive Drug Sequential Release System for Better Eradicating Amyloid Aggregates.Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease.Development of multifunctional heterocyclic Schiff base as a potential metal chelator: a comprehensive spectroscopic approach towards drug discovery.Computer-assisted designed "selenoxy-chinolin": a new catalytic mechanism of the GPx-like cycle and inhibition of metal-free and metal-associated Aβ aggregation.1,2,3,4,6-penta-O-galloyl-β-D-glucopyranose Binds to the N-terminal Metal Binding Region to Inhibit Amyloid β-protein Oligomer and Fibril Formation.
P2860
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P2860
Rational design of a structural framework with potential use to develop chemical reagents that target and modulate multiple facets of Alzheimer's disease.
description
2013 nî lūn-bûn
@nan
2013 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Rational design of a structura ...... facets of Alzheimer's disease.
@ast
Rational design of a structura ...... facets of Alzheimer's disease.
@en
type
label
Rational design of a structura ...... facets of Alzheimer's disease.
@ast
Rational design of a structura ...... facets of Alzheimer's disease.
@en
prefLabel
Rational design of a structura ...... facets of Alzheimer's disease.
@ast
Rational design of a structura ...... facets of Alzheimer's disease.
@en
P2093
P2860
P50
P356
P1476
Rational design of a structura ...... facets of Alzheimer's disease.
@en
P2093
Akiko Kochi
Hyuck Jin Lee
Hyun Min Park
Janarthanan Krishnamoorthy
Jeffrey S Derrick
Jin Hoon Kim
Mi Hee Lim
Michael T Bowers
Sanghyun Lee
P2860
P304
P356
10.1021/JA409801P
P407
P577
2013-12-27T00:00:00Z