TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus - sprookjes - yvandenbroek - TriplyDB

TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

http://www.wikidata.org/entity/Q33902262

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Recognition of damage-associated molecular patterns related to nucleic acids during inflammation and vaccination The germinal center antibody response in health and disease Intracellular nucleic acid sensors and autoimmunity Cytosolic DNA sensing via the stimulator of interferon genes adaptor: Yin and Yang of immune responses to DNA TLRs and interferons: a central paradigm in autoimmunity Toll-like receptors in the pathogenesis of autoimmune diseases: recent and emerging translational developments Sexual dimorphism in autoimmunity Nucleic Acid-Sensing Receptors: Rheostats of Autoimmunity and Autoinflammation The receptor TREML4 amplifies TLR7-mediated signaling during antiviral responses and autoimmunity Nucleic acid scavenging polymers inhibit extracellular DNA-mediated innate immune activation without inhibiting anti-viral responses Estrogen receptor alpha modulates Toll-like receptor signaling in murine lupus HLA-DR3 restricted T cell epitope mimicry in induction of autoimmune response to lupus-associated antigen SmD Targeting cell surface TLR7 for therapeutic intervention in autoimmune diseases.Bacterial amyloid curli acts as a carrier for DNA to elicit an autoimmune response via TLR2 and TLR9 Pathways leading to an immunological disease: systemic lupus erythematosus.Dosage of X-linked Toll-like receptor 8 determines gender differences in the development of systemic lupus erythematosus.Leaky Gut As a Danger Signal for Autoimmune Diseases RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events.Spontaneous activation of RNA-sensing pathways in autoimmune disease.Requirement for MyD88 signaling in B cells and dendritic cells for germinal center anti-nuclear antibody production in Lyn-deficient mice Altered B cell signalling in autoimmunity.Interferon regulatory factor-5 deficiency ameliorates disease severity in the MRL/lpr mouse model of lupus in the absence of a mutation in DOCK2.Toll-like receptor signaling: a potential link among rheumatoid arthritis, systemic lupus, and atherosclerosis.Humanized TLR7/8 expression drives proliferative multisystemic histiocytosis in C57BL/6 mice.B cell-intrinsic TLR7 signaling is essential for the development of spontaneous germinal centers.Autoimmune skin inflammation is dependent on plasmacytoid dendritic cell activation by nucleic acids via TLR7 and TLR9.Dendritic cells in lupus are not required for activation of T and B cells but promote their expansion, resulting in tissue damage Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment.Requirements for innate immune pathways in environmentally induced autoimmunity.Bruton's tyrosine kinase mediates the synergistic signalling between TLR9 and the B cell receptor by regulating calcium and calmodulin TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNS TLR7- and TLR9-responsive human B cells share phenotypic and genetic characteristics.Using Poly I:C as an adjuvant does not induce or exacerbate models of systemic lupus erythematosus.Cytokine disturbances in systemic lupus erythematosus.B cell-derived IL-10 does not regulate spontaneous systemic autoimmunity in MRL.Fas(lpr) mice.A tolerogenic role for Toll-like receptor 9 is revealed by B-cell interaction with DNA complexes expressed on apoptotic cells Toll-like receptors: potential targets for lupus treatment Unbiased modifier screen reveals that signal strength determines the regulatory role murine TLR9 plays in autoantibody production.Murine gammaherpesvirus 68 infection protects lupus-prone mice from the development of autoimmunity.BANK1 Regulates IgG Production in a Lupus Model by Controlling TLR7-Dependent STAT1 Activation.

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TLR9 regulates TLR7- and MyD88-dependent autoantibody production and disease in a murine model of lupus

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2010年の論文

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TLR9 regulates TLR7- and MyD88 ...... ase in a murine model of lupus

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TLR9 regulates TLR7- and MyD88 ...... ase in a murine model of lupus

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TLR9 regulates TLR7- and MyD88 ...... ase in a murine model of lupus

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TLR9 regulates TLR7- and MyD88 ...... ase in a murine model of lupus

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TLR9 regulates TLR7- and MyD88 ...... ase in a murine model of lupus

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TLR9 regulates TLR7- and MyD88 ...... ase in a murine model of lupus

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TLR9 regulates TLR7- and MyD88 ...... ase in a murine model of lupus

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Daniel Kim

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Jonathan Shupe

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Keith Elkon

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Kevin M Nickerson

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Mark J Shlomchik

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Michael Kashgarian

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Sean R Christensen

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P2860

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

Trex1 prevents cell-intrinsic initiation of autoimmunity

Opposing activities of two novel members of the IL-1 ligand family regulate skin inflammation

Novel packages of viral and self-antigens are generated during apoptosis

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA

Lethal anemia caused by interferon-beta produced in mouse embryos carrying undigested DNA

Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus

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1840-1848

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10.4049/JIMMUNOL.0902592

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4

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184

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2010-01-20T00:00:00Z

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41102074

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20089701

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Toll-like receptor

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4098568

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