Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
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The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1aOverexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behaviorRecombinant production and solution structure of PcTx1, the specific peptide inhibitor of ASIC1a proton-gated cation channelsSolution structure of Phrixotoxin 1, a specific peptide inhibitor of Kv4 potassium channels from the venom of the theraphosid spider Phrixotrichus auratusThe tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinityPsalmotoxin-1 docking to human acid-sensing ion channel-1Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependentAcid-sensing ion channels in pain and disease.Structure and activity of the acid-sensing ion channelsIon channels as drug targets in central nervous system disordersStructural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexesSea Anemone Peptide with Uncommon -Hairpin Structure Inhibits Acid-sensing Ion Channel 3 (ASIC3) and Reveals Analgesic ActivityX-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective ChannelChemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2Two aspects of ASIC function: Synaptic plasticity and neuronal injury.Up-regulation of acid-gated Na(+) channels (ASICs) by cystic fibrosis transmembrane conductance regulator co-expression in Xenopus oocytesSelective regulation of acid-sensing ion channel 1 by serine proteasesAnnexin II light chain p11 promotes functional expression of acid-sensing ion channel ASIC1aAcid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neuronsIsolation of an orally active insecticidal toxin from the venom of an Australian tarantulaASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neuronsKnockout of the ASIC2 channel in mice does not impair cutaneous mechanosensation, visceral mechanonociception and hearingNeurosensory mechanotransduction through acid-sensing ion channelsThe Concise Guide to PHARMACOLOGY 2013/14: ion channelsAcid-sensing ion channels in mouse olfactory bulb M/T neurons.ASIC1a regulates insular long-term depression and is required for the extinction of conditioned taste aversionSelective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury.Isolation and characterization of Psalmopeotoxin I and II: two novel antimalarial peptides from the venom of the tarantula Psalmopoeus cambridgei.Functional properties and pharmacological inhibition of ASIC channels in the human SJ-RH30 skeletal muscle cell line.Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs.Dynorphin opioid peptides enhance acid-sensing ion channel 1a activity and acidosis-induced neuronal death.Acid-Sensing Ion Channels and PainProtons and Psalmotoxin-1 reveal nonproton ligand stimulatory sites in chicken acid-sensing ion channel: Implication for simultaneous modulation in ASICs.Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdala.Use of venom peptides to probe ion channel structure and function.Extracellular acidosis activates ASIC-like channels in freshly isolated cerebral artery smooth muscle cellsAcid-sensing ion channels contribute to synaptic transmission and inhibit cocaine-evoked plasticity.Acid-sensing ion channels in acidosis-induced injury of human brain neuronsAcid-sensing ion channels (ASICs): therapeutic targets for neurological diseases and their regulation
P2860
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P2860
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
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name
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
@ast
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
@en
type
label
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
@ast
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
@en
prefLabel
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
@ast
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.
@en
P2093
P2860
P356
P1476
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels
@en
P2093
Champigny G
De Weille JR
Escoubas P
Lazdunski M
P2860
P304
25116-25121
P356
10.1074/JBC.M003643200
P407
P50
P577
2000-08-01T00:00:00Z