The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. - sprookjes - yvandenbroek - TriplyDB

The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.

The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.

http://www.wikidata.org/entity/Q33909482

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A two-stage meta-analysis identifies several new loci for Parkinson's disease Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice LRRK2 as a Potential Genetic Modifier of Synucleinopathies: Interlacing the Two Major Genetic Factors of Parkinson's Disease Ten years and counting: moving leucine-rich repeat kinase 2 inhibitors to the clinic Genetics of Parkinson's disease - a clinical perspective LRRK2 at the interface of autophagosomes, endosomes and lysosomes Identification and characterization of a leucine-rich repeat kinase 2 (LRRK2) consensus phosphorylation motif Genetic susceptibility in Parkinson's disease Genetic mouse models of parkinsonism: strengths and limitations.Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration The curious case of phenocopies in families with genetic Parkinson's disease.Leucine-rich repeat kinase 2-linked Parkinson's disease: clinical and molecular findings.Familial Parkinsonism and early onset Parkinson's disease in a Brazilian movement disorders clinic: phenotypic characterization and frequency of SNCA, PRKN, PINK1, and LRRK2 mutations Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations.Progressive supranuclear palsy in a family with TDP-43 pathology Leucine-rich repeat kinase 2: a new player with a familiar theme for Parkinson's disease pathogenesis.Genetics of Parkinson's disease: LRRK2 on the rise.The genetics of Parkinson disease.Patterns of linkage disequilibrium of LRRK2 across different races: implications for genetic association studies.Genetic Mutation Analysis of Parkinson's Disease Patients Using Multigene Next-Generation Sequencing Panels.Parkinson's disease: the genetics of a heterogeneous disorder.Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction.Leucine-rich repeat kinase 2 mutations and Parkinson's disease: three questions.Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease.The function of orthologues of the human Parkinson's disease gene LRRK2 across species: implications for disease modelling in preclinical research.Genetic insights into sporadic Parkinson's disease pathogenesis.DNA methylation in neurodegenerative disorders: a missing link between genome and environment?Analysis of mitochondrial structure and function in the Drosophila larval musculature.Leucine-Rich Repeat Kinase (LRRK2) Genetics and Parkinson's Disease.Genetics of Parkinson's disease and parkinsonism.P53 Dysfunction in Neurodegenerative Diseases - The Cause or Effect of Pathological Changes?Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects.The impact of genetic research on our understanding of Parkinson's disease Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies.The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease.Parkinson's disease: leucine-rich repeat kinase 2 and autophagy, intimate enemies.Caenorhabditis elegans neuron degeneration and mitochondrial suppression caused by selected environmental chemicals

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The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval.

http://www.wikidata.org/entity/Q33909482

description

2003 nî lūn-bûn

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2003 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2003 թվականի դեկտեմբերին հրատարակված գիտական հոդված

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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The PARK8 locus in autosomal d ...... e disease-containing interval.

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American Journal of Human Genetics

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The PARK8 locus in autosomal d ...... e disease-containing interval.

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Audrey Strongosky

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Erwin Ott

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Friedrich Asmus

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Jennifer Kachergus

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Karoline Wenzel

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Manu Sharma

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Mary Hulihan

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Nikolaus Homann

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Petra Leitner

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Ronald F Pfeiffer

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P2860

Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase

Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism

Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism

Mutation in the alpha-synuclein gene identified in families with Parkinson's disease

Lewy bodies and parkinsonism in families with parkin mutations

Mapping of a gene for Parkinson's disease to chromosome 4q21-q23

Ala30Pro mutation in the gene encoding alpha-synuclein in Parkinson's disease

Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results

Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred.

Parkinson's Disease Society Brain Bank, London: overview and research.

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11-19

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scholarly article

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10.1086/380647

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1

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74

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Bertram Müller-Myhsok

Alexander Zimprich

Claudia Trenkwalder

Matthew J. Farrer

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Donald Brian Calne

John Anthony Hardy

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2003-12-19T00:00:00Z

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8945108

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14691730

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Parkinson's disease

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