Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
about
Nucleases in homologous recombination as targets for cancer therapyX-ray structures of checkpoint kinase 2 in complex with inhibitors that target its gatekeeper-dependent hydrophobic pocketAcute MUS81 depletion leads to replication fork slowing and a constitutive DNA damage response.Chk2 phosphorylation of survivin-DeltaEx3 contributes to a DNA damage-sensing checkpoint in cancer.Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.Cell cycle proteins as promising targets in cancer therapyMus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathwayTargeting Chk2 improves gastric cancer chemotherapy by impairing DNA damage repair.Cooperation of Blm and Mus81 in development, fertility, genomic integrity and cancer suppression.Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.
P2860
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P2860
Inactivation of chk2 and mus81 leads to impaired lymphocytes development, reduced genomic instability, and suppression of cancer.
description
2011 nî lūn-bûn
@nan
2011 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年学术文章
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2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
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name
Inactivation of chk2 and mus81 ...... ty, and suppression of cancer.
@ast
Inactivation of chk2 and mus81 ...... ty, and suppression of cancer.
@en
type
label
Inactivation of chk2 and mus81 ...... ty, and suppression of cancer.
@ast
Inactivation of chk2 and mus81 ...... ty, and suppression of cancer.
@en
prefLabel
Inactivation of chk2 and mus81 ...... ty, and suppression of cancer.
@ast
Inactivation of chk2 and mus81 ...... ty, and suppression of cancer.
@en
P2093
P2860
P1433
P1476
Inactivation of chk2 and mus81 ...... ty, and suppression of cancer.
@en
P2093
Anne Hakem
Ashwin Pamidi
Atsushi Hirao
Manoor Prakash Hande
Marie Jo Halaby
Miyuki Bohgaki
Razqallah Hakem
Renato Cardoso
Samah El Ghamrasni
P2860
P304
P356
10.1371/JOURNAL.PGEN.1001385
P577
2011-05-19T00:00:00Z