Chaperoning G protein-coupled receptors: from cell biology to therapeutics
about
Monitoring G protein-coupled receptor and β-arrestin trafficking in live cells using enhanced bystander BRETRecent advances in understanding the extracellular calcium-sensing receptor"Been hit twice": a novel bi-allelic heterozygous mutation in LHCGR.A small molecule agonist THIQ as a novel pharmacoperone for intracellularly retained melanocortin-4 receptor mutants.Ipsen 5i is a Novel Potent Pharmacoperone for Intracellularly Retained Melanocortin-4 Receptor Mutants.Defect in MAPK signaling as a cause for monogenic obesity caused by inactivating mutations in the melanocortin-4 receptor gene.Biased signaling in naturally occurring mutations in human melanocortin-3 receptor gene.Functions of DPLIY motif and helix 8 of human melanocortin-3 receptor.Misfolded opsin mutants display elevated β-sheet structure.The safety dance: biophysics of membrane protein folding and misfolding in a cellular contextPharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias.Disease-associated extracellular loop mutations in the adhesion G protein-coupled receptor G1 (ADGRG1; GPR56) differentially regulate downstream signaling.Regulation of GPCR expression through an interaction with CCT7, a subunit of the CCT/TRiC complex.The retinoblastoma protein regulates hypoxia-inducible genetic programs, tumor cell invasiveness and neuroendocrine differentiation in prostate cancer cells.Fertility and fragrance: another cause of Kallmann syndrome.Functional Rescue of a Misfolded Drosophila melanogaster Dopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones.Relax, Cool Down and Scaffold: How to Restore Surface Expression of Folding-Deficient Mutant GPCRs and SLC6 Transporters.Orphan neuropeptides and receptors: Novel therapeutic targets.Intracellular Trafficking of Gonadotropin Receptors in Health and Disease.Pharmacoperones as Novel Therapeutics for Diverse Protein Conformational Diseases.Comparison of the β-Adrenergic Receptor Antagonists Landiolol and Esmolol: Receptor Selectivity, Partial Agonism, and Pharmacochaperoning Actions.Ligand channel in pharmacologically stabilized rhodopsin.Modeling mutant/wild-type interactions to ascertain pathogenicity of PROKR2 missense variants in patients with isolated GnRH deficiency.GnRH ActionGlucose-regulated protein 78 binds to and regulates the melanocortin-4 receptor
P2860
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P2860
Chaperoning G protein-coupled receptors: from cell biology to therapeutics
description
2014 nî lūn-bûn
@nan
2014 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2014 թվականի մարտին հրատարակված գիտական հոդված
@hy
2014年の論文
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2014年論文
@yue
2014年論文
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2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
name
Chaperoning G protein-coupled receptors: from cell biology to therapeutics
@ast
Chaperoning G protein-coupled receptors: from cell biology to therapeutics
@en
type
label
Chaperoning G protein-coupled receptors: from cell biology to therapeutics
@ast
Chaperoning G protein-coupled receptors: from cell biology to therapeutics
@en
prefLabel
Chaperoning G protein-coupled receptors: from cell biology to therapeutics
@ast
Chaperoning G protein-coupled receptors: from cell biology to therapeutics
@en
P2860
P356
P1433
P1476
Chaperoning G protein-coupled receptors: from cell biology to therapeutics
@en
P2093
P Michael Conn
P2860
P304
P356
10.1210/ER.2013-1121
P50
P577
2014-03-24T00:00:00Z