Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization - sprookjes - yvandenbroek - TriplyDB

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

http://www.wikidata.org/entity/Q33933859

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Digitoxin and its analogs as novel cancer therapeutics Monosaccharide digitoxin derivative sensitize human non-small cell lung cancer cells to anoikis through Mcl-1 proteasomal degradation Natural product disaccharide engineering through tandem glycosyltransferase catalysis reversibility and neoglycosylation Enzymatic methods for glyco(diversification/randomization) of drugs and small molecules Influence of Sugar Amine Regiochemistry on Digitoxigenin Neoglycoside Anticancer Activity 21-Benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides: Oligosaccharide Chain Length-Dependent Induction of Caspase-9-Mediated Apoptosis Novel stereoselective bufadienolides reveal new insights into the requirements for Na(+), K(+)-ATPase inhibition by cardiotonic steroids Natural-product sugar biosynthesis and enzymatic glycodiversification.Enhancing the divergent activities of betulinic acid via neoglycosylation.Assessment of chemoselective neoglycosylation methods using chlorambucil as a model.Inactivation of gilGT, encoding a C-glycosyltransferase, and gilOIII, encoding a P450 enzyme, allows the details of the late biosynthetic pathway to gilvocarcin V to be delineated.Neoglycosylation and neoglycorandomization: Enabling tools for the discovery of novel glycosylated bioactive probes and early stage leads.High throughput discovery of heteroaromatic-modifying enzymes allows enhancement of novobiocin selectivity.Enhancement of cyclopamine via conjugation with nonmetabolic sugars RebG- and RebM-catalyzed indolocarbazole diversification.Enzymatic Biosynthesis of Novel Resveratrol Glucoside and Glycoside Derivatives.The impact of enzyme engineering upon natural product glycodiversification Glycosyloxyamine neoglycosylation: a model study using calicheamicin.Stereochemical survey of digitoxin monosaccharides: new anticancer analogues with enhanced apoptotic activity and growth inhibitory effect on human non-small cell lung cancer cell.Warfarin glycosylation invokes a switch from anticoagulant to anticancer activity.Characterization of interactions of 4-nitrophenylpropyl-N-alkylamine with ς receptors.Ginsenosides as Anticancer Agents: In vitro and in vivo Activities, Structure-Activity Relationships, and Molecular Mechanisms of Action.Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.Human cytomegalovirus inhibition by cardiac glycosides: evidence for involvement of the HERG gene.Probing the regiospecificity of enzyme-catalyzed steroid glycosylation.Direct synthesis of β-N-glycosides by the reductive glycosylation of azides with protected and native carbohydrate donors.Increasing carbohydrate diversity via amine oxidation: aminosugar, hydroxyaminosugar, nitrososugar, and nitrosugar biosynthesis in bacteria Digitoxin as an anticancer agent with selectivity for cancer cells: possible mechanisms involved.Hellebrin and its aglycone form hellebrigenin display similar in vitro growth inhibitory effects in cancer cells and binding profiles to the alpha subunits of the Na+/K+-ATPase TMSBr-mediated solvent- and work-up-free synthesis of α-2-deoxyglycosides from glycals Probing 3-hydroxyflavone for in vitro glycorandomization of flavonols by YjiC.A novel extracellular drug conjugate significantly inhibits head and neck squamous cell carcinoma.Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation.Chemical synthesis of the cardiotonic steroid glycosides and related natural products.Modulators of Na/K-ATPase: a patent review.Anticancer steroids: linking natural and semi-synthetic compounds.Oxime ligation: a chemoselective click-type reaction for accessing multifunctional biomolecular constructs.Tubulin inhibitors: a patent review.Synthetic multivalency for biological applications.

P2860

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P2860

Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

http://www.wikidata.org/entity/Q33933859

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2005 թուականի Օգոստոսին հրատարակուած գիտական յօդուած

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

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Proceedings of the National Academy of Sciences of the United States of America

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Enhancing the anticancer properties of cardiac glycosides by neoglycorandomization

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Ilia A Guzei

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Joseph M Langenhan

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Noël R Peters

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P2860

Digitoxin medication and cancer; case control and internal dose-response studies

Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells

An expanded eukaryotic genetic code

Chemical glycobiology

Chemical remodelling of cell surfaces in living animals

Regiocontrolled synthesis of the antitumor antibiotic AT2433-A1.

A new strategy for the synthesis of glycoproteins.

Multiplex gene expression analysis for high-throughput drug discovery: screening and analysis of compounds affecting genes overexpressed in cancer cells.

Antibiotic optimization via in vitro glycorandomization.

Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives.

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